“nominally significant”

This type of association is thus found across the genome, and while nominally significant, is not significant in a genomic sense.

After controlling for sex and age, nominally significant association between sleep and factor scores were observed such that Response Times were faster with more SWS, and Accuracy was reduced where individuals woke more often or had less REM sleep.

Although only nominally significant we did identify P/LP mutations in a number of interesting candidate genes including FLCN , BLM , ERCC -genes and BRCA1/2 as possible determinants of CRC risk.

Results were regarded as nominally significant if p value was less than 0.05.

Notably, an additional seven CpG sites had nominally significant interactions with rs115550680, and one additional site had a nominally significant interaction with rs3764647.

Although SEN-guided MDR only identified a nominally significant network for disease aggressiveness in the current study, this approach overcomes the computational challenge of detecting all possible two-, three- and four-way SNP combinations involved in PCA progression.

AQP1 and SOX17 were both also nominally significant in the combined burden tests, described above.

Only nominally significant associations are shown and all effect sizes are given with respect to the alternative allele.

Marker-by-marker analyses of rs1800888, rs1042718 and rs1042719 of ADRB2 in the present study and the previous published analyses of rs1042713 and rs1042719 [4] showed nominally significant association with waist-to-hip ratio and systolic blood pressure in line with the results seen for haplotype pairs.

The grading was performed in the following manner: Robust evidence for causality was achieved when all the performed methods (i.e., main analysis, and MR-Egger, WM, MRPRESSO, and MVMR) for the specific association presented a nominally significant p value.

The associations for the Hannum clock were not statistically significant from any of the meta-analyses, and the rest of the associations were found to be nominally significant in at least one of the meta-analyses, with the exception that the association between number of live births and genome-wide average DNA methylation was marginally significant ( P = 0.07).

P -values <.05 were considered nominally significant, whereas high-confidence results were those that survived adjustment for multiple testing (Bonferroni correction threshold of 0.05/75).

For each genomewide significant SNP, SHAPE was used to plot the overall effect on hip shape, using a linear combination of beta estimates for all nominally significant SNP‐HSM associations.

We identified proteins that were nominally significant in at least two analyses and aligned in direction in three analyses as potential causal biomarkers.

In support to the pathophysiological roles of the stress score genes, pathway enrichment (gene ontology) analysis of all nominally significant differentially expressed genes between T1D macro- and normoalbuminuria groups also suggested changes in oxidation-reduction as well as transporter and EV-linked activities (p < 0.05, logFC>1, n = 130 genes, Table S8 ).

There was no association with fracture overall (odds ratio [OR] = 1.01 [CI, 0.95 to 1.08]) in either unadjusted or adjusted analyses, but there was a non-significant trend for association with vertebral fracture and a nominally significant association with incident vertebral fractures in females (OR = 1.33 [CI, 1.00 to 1.77]) that was independent of BMD, and unaltered in adjusted analyses.

We found that association with all 19 of these SNPs trended in the same direction in this large multiethnic study, and the majority of these variants were nominally significant in their association with diabetes risk.

To further reduce the number of false positives, for each potential omics-specific QTL identified at 10% FDR we further test genotype association with the other two omics-types and remove any variant that has nominally significant association.

Moreover, women who reported a relatively higher percentage of energy from dietary fat at baseline (≥36.8% of energy from fat) made larger reductions in fat intake and demonstrated a nominally significant reduction in breast cancer risk (HR 0.76) [ 24 ].

Poor or fair self-rated mental health and Total Somatic Symptoms were nominally significant after controlling for the other terms (see Table 4 ). 4.2.3.

A nominally significant association was noted between prolactin levels and a tagSNP (tagSNP 44, rs2244502) in intron 1 of PRL.

A P value of <0.05 was considered nominally significant, and a q -value (FDR-adjusted P value) of <0.05 was considered significant after multiple comparison adjustment.

All of the 56 non-replicated proteins available in HUNT showed concordant direction of effect between the cohorts, and 35 of them were nominally significant in HUNT (Fig. 1 b).

As this work is exploratory in nature, the number of comparisons conducted relative to the available sample size limits the interpretability of individual P values, and many nominally significant associations do not survive multiple testing correction; nonetheless, the consistency and strength of the associations observed with cardiac fibrosis are notable and warrant further investigation in larger cohorts.

17d ), reveals a significant preponderance of small P values <10 −3 , suggesting many of these nominally significant SNPs likely represent true signals 12 .