“nominally significant”

Nominally significant single SNPs and/or haplotype-based association results were detected in 15 genes, of which, MYO1D , ACCN1 and LASP1 stand out as genes with autism risk alleles [ 42 ].

We also observed nominally significant changes in the frequency of action potentials during differentiation, where the speed at which the edited and unedited cells reach the same level of activity differs.

Although we found nominally significant associations with diastolic blood pressure, waist circumference, and smoking, these associations did not persist after correction for multiple testing.

Among AA, no single SNP was at least nominally significant.

At the taxon level, the nominally significant decreases in Tissierellia -associated genera (Peptostreptococcus , Parvimonas, Peptoniphilaceae ) and in the Fusobacterium nucleatum group are consistent with the observed decline in CRC- and inflammation-associated taxa in the Del-Immune V arm, as captured by both the guild analysis and the CRC dysbiosis index.

Other, nominally significant associations are listed below.

Nominally significant genetic correlations highlighted in bold.

29 , 30 , 32 , 35 An interaction was observed for major bleeding with apixaban (interaction p value = 0.030); where patients with moderate renal impairment had a nominally significant greater reduction in major bleeding [hazard ration (HR): 0.53; 95% confidence interval (CI): 0.39–0.71], as compared with differences between apixaban and warfarin in patients with normal renal function (HR: 0.79; 95% CI: 0.61–1.04) and mild renal impairment (HR: 0.76; 95% CI: 0.62–0.94). 6 It is not known whether the observed benefit with apixaban is related to the molecule, to chance, other confounders, or possibly to a higher-than-expected bleeding rate with warfarin in the moderate renal subgroup of this trial ( Figure 10B ).

For the educational attainment phenotypes, 17 and 14 of the top 25 genes associated with years of education and college completion, 35 respectively, were nominally significant in the current gene-based results.

When the percentage of time in each sleep stage (rather than minutes in each stage) was analyzed, only the percentage of REM sleep showed nominally significant increases compared with placebo for most of the filorexant doses (night 1: 2.5% to 3.3%; week 4: -0.8% to 2.1%).

A Bonferroni-corrected P-value less than 0.05/5 (0.01) was identified as statistically significant, and a P-value less than 0.05 was identified as nominally significant.

Similarly, other linker histones, including H1.1, H1.3, and H1.4, also displayed nominally significant associations (Fig. 1 B).

The total number of CREs with nominally significant differential signal P -values has less effect on the total number of significant DegCre associations ( Supplemental Fig. 1C ).

Findings for UPCR remained nominally significant after further adjustment for eGFR, while eGFR findings were attenuated on adjustment for UPCR.

We also tested whether there were changes in serum levels of TLR-2 and of zonulin, a marker of gut inflammation, and found no significant change in TLR-2 in either the treatment or pectin arm and a nominally significant drop in zonulin in the pectin arm ( Table 2 ).

Only IVF ( P = 0.016) and sequencing depth of the sire ( P = 0.028) were nominally significant.

We identified 42 nominally significant associations and 2 robust causative links.

We performed ORA to test whether the nominally significant metabolites were found within a metabolite set more often than expected by chance.

Nine proteins out of the 273 significant proteins ( P < 0.05) were shared between datasets, of which three were nominally significant in both cohorts and all with concordant direction of effect (Supplementary Fig.

There was a nominally significant positive association between age 14 EDE-Q global scores and DunedinPACE using the basic covariate model (sex, age 17 EDE-Q global scores) and in the lifestyle model (sex, age 17 EDE-Q global scores, age 17 BMI centile, smoking status) (Table 2 ), but neither effect survived the FDR correction.

Using only cases with a negative family history (n=133), the two loci showed nominally significant p values (rs12469063, P nom =0.038, P corrected =0.224; rs2300478, P nom =0.055, P corrected =0.306, and rs3923809, P nom =0.025, P corrected =0.147).

Because the primary endpoint based on nasopharyngeal swab samples was not met, however, any a priori statistical testing of study endpoints based on saliva samples could only be considered hypothesis generating and a p-value <0.05 nominally significant.

The other 13 associations, while nominally significant in the IVW analysis, did not withstand FDR correction.

In PSEN2 carriers, 11 total analytes were nominally significant, of which 6 were common in all three types of MCs.

Results: Higher genetically predicted IGF-1 levels have nominally significant association with reduced risk of COVID-19 susceptibility and hospitalization.