“nominally significant”

We corrected for multiple tests in each group using the false discovery rate (FDR) and considered FDR <0.10 as significant and uncorrected P < 0.05 as nominally significant.

With regard to other previously reported loci, associations with total and HMW adiponectin levels reached genome-wide significance for ADIPOQ (rs10937273), and we observed nominally significant associations for GPR109A (rs601339), CMIP (rs2925979), and PEPD (rs731839) ( Supplementary Table 2 ).

Regarding synonymous URVs, we observed nominally significant excess in EE/DEE (Fig. 1a ).

Raw p-values < 0.05 were nominally significant.

Post-treatment, several cytokines, predominantly proinflammatory and chemotactic factors, showed nominally significant increases.

Because estimates close to zero could change sign stochastically, we considered just the SNPs with true effects on the outcome Y and nominally significant associations after adjustment for collider bias.

Of the 16 endophenotypes considered, only the 4-digit CPT-IP (CPT-IP 4-digit) and CNB verbal memory test showed nominally significant associations with paternal age.

Although RALY showed a nominally significant association in the SMR analysis, it failed to pass the HEIDI test ( p HEIDI = 0.002889), indicating heterogeneity among instrumental variants. 3.4.

For reducing the computation cost, most of the time epistasis analyses have been conducted for the SNPs, which are nominally significant in the single-locus analysis. 61 , 62 We performed whole genome pairwise epistasis analysis for rice flowering time and identified 589 epistatic interactions comprised 499 SNPs.

All covariates being still nominally significant were considered as associated to adherence/persistence.

(see supplementary appendix Table S2 of [ 18 ]) [ 18 ] reported adjusted HRs (based on a Cox regression model including treatment group and the respective baseline characteristics), where stratifying for AFP was the only variable to produce a nominally significant OS HR (0.856, CI 0.736–0.995).

Following DBT, a nominally significant increase in DNAm was observed, aligning with inversely correlated symptom severity.

A nominally significant decrease of CXCL-4 and sPECAM-1 from baseline to week 14 suggests anti-inflammatory properties of riociguat in patients with dcSSc and our findings suggest patients with increased circulating sPECAM-1 at baseline may have a greater response to riociguat.

Nominally significant associations with aspirin use were reported for a number of cancer outcomes: CRC incidence/mortality, gastric cancer incidence, breast cancer incidence/mortality, prostate cancer incidence and lung cancer incidence.

p Values < .05 were considered nominally significant because no multiplicity adjustments were conducted.

For binary outcomes, p < 0.05 was considered nominally significant.

Within the primary analyses, while there were trends of interest, no other pathways were method-wide or nominally significant.

For example, in 2016 African American (AA) breast cancer patients and 2745 controls, 36 of 47 (67 %) EA breast cancer risk SNPs had ORs in AA in the same direction, and seven (15 %) had nominally significant P values [ 36 ].

Only two of the genes, SLC45A3 and NUCKS1 , were nominally significant in both levels of analyses.

In this study, results with FDR q-value < 0.1 were defined as significant; results with P < 0.05 but FDR q-value > 0.1 were defined as nominally significant ( 40 , 41 ).

Other HLA alleles with nominally significant associations are shown in Dataset S1 .

After the removal of PCA outliers, the first and second principal components showed a nominally significant association with AD, and were included as covariates in all association analyses.

Even in instances of nominally significant genes only moderately exceeding chance expectations by FDR, the nominally significant genes were found in downstream enrichment analyses (involving functional gene sets and results of external SARS-CoV-2-related RNA-seq datasets) to contain biological information.

The direction of associations between many cortical volumes and internalizing problem scores was now positive, although only one was nominally significant.

The vertical line shows the nominally significant p-value threshold, 0.05.