“nominally significant”

Although the SMR analysis for mitochondrial gene expression yielded an FDR-corrected p-value (0.050443) marginally above the significance threshold ( Data Sheet - Supplementary Table 5 ), the nominally significant SMR p-value ( P SMR = 1.74×10 -3 ) in conjunction with a non-significant HEIDI test (HEIDI > 0.05) supports a suggestive association between FXN gene expression and nephrolithiasis.

Among them, 14 associations were nominally significant.

First, we asked whether the number of nominally significant genes were higher than expected by chance.

Of the 57 consistently changing proteins, 12 showed mild but nominally significant correlations with cardiopulmonary hemodynamic changes at week 24 in a direction of improvement.

In contrast, the number of positive intra-area correlations of opioid genes with neuroplasticity-related genes for the right half of the spinal cord was significantly different ( p unadjusted = 8.4e-05) between the five animal groups while for the left half was nominally significant ( p unadjusted = 0.048; Fig. 5 ).

We did not find any significant associations after adjusting for the 489 allele/outcome combinations tested ( Figure 3 ; Table S6 ) and did not find any nominally significant associations with any of the major risk HLA alleles for the four indications, with the HLA-Cw6 (C ∗ 06) allele previously associated with response to anti-IL17 therapy 26 or with the HLA-DQA1 ∗ 05 alleles previously associated with TNFi immunogenicity 14 , 15 , 16 ( Table S4 ).

In mouse astroglia transduced with Ngfr versus control astroglia, we identified 152 genes that are significantly DEGs, of which 61 are also nominally significant DEG in at least one ROSMAP brain region (Fig. 7b and Supplementary Data S).

The results showed that three sphingomyelins significantly correlated with the abundances of several proteins, positively with 14 proteins and negatively with 29 proteins, while in total, 25 of these proteins were nominally significant between PD and control in the proteomic data alone.

Only three (cg19534438 in G0S2 , cg05575921 and cg26703534 in AHRR ) were nominally significant with the same direction in Meta-Analysis 1.

[ 3 ] found that psychostimulant use was nominally significant associated with smaller surface area among children with ADHD, suggesting that medications may explain some of the brain size differences seen in ADHD.

A P value of < 0.05 was considered nominally significant.

The two SNPs in the α-2C adrenergic receptor that were nominally significant in the additive model (without correction for multiple tests, Table 4 ) made small contributions to the variance in movement scores – approximately 0.6% and 0.9% (partial R 2 ).

After adjusting for age, ordinal regression analysis showed a nominally significant increase in the odds of achieving a better rating for delandistrogene moxeparvovec-treated patients on all four CaGI-C items (≥ 3.8-fold increase).

Although the AD association at the IQCK locus was identified only in one paper [ 2 ], nominally significant associations were also found in more powered AD GWAS [ 1 ] (Fig. 3 C).

Pathway-Based Microarray Meta-Analysis The meta-pathway analysis conducted with MetaPath using the Molecular Signatures Database Hallmark gene set did not identify biological processes significantly perturbed after FDR correction, but 3 nominally significant processes ( supplementary Table 6 ).

However, investigation of the nominally significant genes can be informative for potential roles of several genes in ASD risk.

Nevertheless, all SNPs except rs10915437 (near AJAP1 ) had at least one model with nominally significant empirical p-value for the LLR test (i.e. <0.05), and the same five SNPs that had empirically significant LLR tests in the BIC model selection were also significant in the AIC model selection, although in some cases different models were selected ( Tables 4 & S3 A, B, C).

Consequently, subgroup differences and nominally significant findings for secondary angiographic endpoints should be regarded as exploratory, particularly given the multiplicity of comparisons.

Using the regression coefficients of the 9 nominally significant (α = 0.05) SNPs (rs885479, rs1805008, rs1805007, rs28777, rs12896399, rs1042602, rs1393350, rs12821256, rs12203592; see Supplementary Table S2 , available) as weights, we calculated a polygenic score in the cortisol/cortisone sample according to β 1 *rs885479 + ... + β 9 * rs12203592.

Nevertheless, the low-frequency allele also showed nominally significant association with increased risk of gestational diabetes mellitus and type 2 diabetes in publicly available FinnGen data [ 33 ] (gestational diabetes: logistic β=0.619 per addition of the minor G allele, SE=0.166, p =2×10 −4 ; type 2 diabetes: logistic β=0.299 per addition of the minor G allele, SE=0.070, p =2×10 −5 ), and decreased (inverse rank normal transformed) glucose levels ( p =1.9×10 −4 ), but not type 2 diabetes, HbA 1c or offspring birthweight (all p >0.05), in publicly available GWAS summary statistics from the UKBB published on the Neale website ( https://www.nealelab.is/ ).

We additionally identified other genes that were only nominally significant, but had suggestive functional or phenotypic evidence and could achieve genome-wide significance in a larger cohort.

Even though they are in different equivalence classes in Africans, nominally significant ORs were observed for rs9397435, rs12662670, rs12665607, and rs9383589 ( Table 1 ).

Lastly, we identified GM taxa with nominally significant associations with GC, though these associations lost significance after applying multiple correction tests.

We applied a Hochberg step-up correction ( 31 , 32 ) to control overall type I error at 5% in the context of multiple testing under each of these over-arching hypotheses; any p < 0.05 is considered nominally significant.

Eosinophil-associated SNPs demonstrated nominally significant associations with progression of IMT-CC max , but only rs2706399 (the G allele of which was previously associated with increased CVD risk [6] ) met the Bonferonni-corrected p for significance (G allele, Beta −0.008, 95%CI (−0.012, −0.004), p = 0.0017, Supplementary Table 3 ).