“nominally significant”

A nominally significant difference emerged between neutral and incongruent reflexives, t (50.9) = -2.52, p = 0.015, d z = −0.41, 95% CI [−0.74, −0.08], though given the exploratory nature of this analysis and the absence of a theoretically motivated account for this pattern in bound-variable contexts, this result should be interpreted cautiously.

Meta-analysis of polygenic score associations across the three prospectively assessed cohorts (Janssen, Douglas Biomarker Study, and IRL-GREY study) showed nominally significant evidence of association for the remission polygenic score (maximum liability R 2 = 0.8%, p = .015) and a nonsignificant association for the percentage improvement score (maximum R 2 = 0.2%, p = .091) ( Figure S21 in Supplement 1 ).

In meta-analysis, only the HLA-DQB1 variant showed a nominally significant independent replication for a variant in HLA-DQB1 (OR = 15.6, P = 0.015, positive predictive value = 35.1), while a novel variant in rs149104283, an intronic transcript of SLCO1B3 and SLCO1B7 , was associated with CIAG (OR = 4.32, P = 1.79 × 10 −8 ) (Legge et al. 2017 ), but was not replicated in a Japanese sample (Saito et al. 2017 ).

Interaction was nominally significant but much weaker when analyzing ratings of female coders (effect = -0.181, p = 0.015).

Associations of CNR1 with CIP in EA family sample For CIP, nominally significant association signals were observed at two SNP8-linked loci, i.e., rs1049353 (SNP7) ( P =0.015) and rs2146274 (SNP10) ( P =0.010).

The only discordance concerned reticulocytes at T0, where the Pearson coefficient was nominally significant (r = 0.369, p = 0.015), whereas the Spearman coefficient was not (ρ = 0.268, p = 0.082).

We found nominally significant associations of 7 SNPs with at least one smoking-related phenotype in the total sample (SI: P = 0.015∼0.023; SQ: P = 0.008∼0.028; SC: P = 0.018∼0.047) and the male sample (SI: P = 0.001∼0.023; SQ: P = 0.001∼0.046; SC: P = 0.01).

In the younger group, there were nominally significant weak correlations between the ACC interference effect and the connectivity between the FPN and the DAN (Spearman's ρ: −0.44, p = 0.015) and between the FPN and the DMN (Spearman's ρ: 0.38, p = 0.039), but these would not survive more stringent correction for multiple testing.

A cross-ancestry meta-analysis of Arg177* and Trp188* variants showed a nominally significant association with reduced IOP (beta allelic = –0.21 SD, P = 1.5 × 10 −2 ; Supplementary Fig. 4 ).

We observed that escitalopram had nominally significant interaction signals in participants who also took hydrochlorothiazide (e.g., interaction HR [HRi] = 1.46 [1.08–1.97], P = 0.015, compared with sertraline) or ACEi/ARBs (HRi = 1.37 [1.02–1.84], P = 0.037, compared with citalopram; Figure S5A,B ).

To further explore the potential target of these two variants, GTEx eQTL data for normal ovarian tissue were queried and nominally significant ( p ≤0.015; Supplementary Table 4 ) associations were observed between lower MEF2D expression and the minor alleles of both variants, but not with expression of the neighboring IQGAP3 gene.

Results One SNP ( rs8006686 ) in MTHFD1 showed a nominally significant association with PXFG (p=0.015, OR=2.23).

All plasma biomarkers were associated with an increase in Aβ PET Centiloids but only the interaction between plasma p-tau231 and Aβ status was nominally significant ( P = 0.015) (Supplementary Table 9 and Supplementary Fig. 4 ).

However, the impact of SZ specific was less pronounced (β = −0.08, p = 2.2e-09), and intriguingly, SZ-PGS showed a nominally significant positive association with EA (β = 0.03, p = 0.015).

Analysis of previous associated SNPs in different LD-Blocks, located intronic (rs9804190 and rs10761482) or 30 kb downstream of ANK3 (rs10994336) found a nominally significant association of SNP rs10761482 with bipolar disorder (p = 0.015, OR 1.304) but not with schizophrenia (table 1 and 2 ).

The CHRN Variants May Regulate the Expression of CHRN Genes ( Table 4 ) Cis- eQTL analysis showed that 13 risk SNPs at CHRNB3-CHRNA6 had nominally significant cis- acting regulatory effects on CHRNB3 mRNA expression in cerebellar cortex and thalamus ( p = 0.015–0.022 and 0.026–0.031, respectively), and on CHRNA6 mRNA expression in frontal cortex and hippocampus ( p = 0.042–0.043 and 0.027–0.033, respectively).

Stratifying by quartiles of the genetic score, we only found a nominally significant effect of quantile 4 compared with quantile 1 of the score on FA (OR, 0.73; 95% CI, 0.57–0.94; P =0.015).Odds ratios±SE for WMH, FA, and MD based on the quartiles of the genetic score were plotted (Figures I through III in the online-only Data Supplement ).

Results Associations with fasting glucose Of the 16 SNPs studied, 12 displayed β-values with the same direction of effect as that seen in Europeans, and the SLC30A8 rs11558471 variant displayed a nominally significant association with fasting glucose levels (β = 0.063 [95% CI: 0.013, 0.113] p = 0.015) ( Figure 1 ).

Testing the 10 deciles of LoF intolerance for enrichment with TD summary statistics revealed nominally significant overlap in the most intolerant 2 deciles ( p = .015 and p = .032) ( Figure S4 ).

Consistent with the prolongation of total sleep duration in the shortest night, a nominally significant effect was also seen for the total duration in bed during the night ( p = 0.015, r = 0.40) with an estimated increase in time in bed of 0.99 h (59 min) in the verum group compared to the placebo group (Table 2 ).

For the candidate SNP analysis, a nominally significant association was found with a SNP in the MC1R gene (p= 0.0157).

“Skip 44”mutations showed nominally significant increases of FVC with the meta‐analysis approach (+7.1 ± 3.3%, P = 0.016). “Skip 8” mutations were associated with dramatic increases of PEF (+20.0 ± 4.5%) and nominally significant increases of FVC (+13.8 ± 8.3%) and FEV1 (+15.3 ± 7.9%).

The magnitude of the association with lower FEV 1 increased to some extent in older groups, but only a nominally significant trend in the association effect size across age groups was found ( p = 0.016).

For example, ARID1A , which is part of the ATP-dependent chromatin remodeling complex SNF/SWI, was associated with sensitivity to topotecan, a DNA topoisomerase I inhibitor, in STAD ( P BH = 1.68 × 10 −3 ) and nominally significant in UCEC (raw P = 0.016).

The linear interaction between continuous baseline NIHSS and cardioembolism was nominally significant ( p = 0.016) and remained significant after Bonferroni correction ( p = 0.048) and FDR correction ( p = 0.048).