“nominally significant”

Even with a conservative Bonferroni correction for 8 tests, 4 lipid levels causing total BMD and total BMD causing 4 lipid measures (threshold of .05/8 = .0063), LDL-C significantly causes total heel BMD, with p -values also nominally significant for right and left heel measures separately.

B-6 interactions involving SNPs in GLDC were among the top nominally significant hits for the homocysteine and Alu methylation phenotypes, but did not reach FDR-significance.

Single-variant Analysis Our primary analysis focused on 481 variants within or near FKBP5 ( S3 Table ), and five of them were differentially represented among suicide attempters and non-attempters at a nominally significant level ( Table 1 ).

By contrast, medication and hospitalization during depressive episodes, both only nominally significant in the primary analysis, were significant after correction for multiple testing in the secondary analysis.

3.2 Factors associated with pulmonary nodules ≥5 mm in the total cohort Significant variables from the overall model and nominally significant variables from the smoking-status-stratified models are summarized in Figure 2 .

In this case the p-value for association, P = 1.9×10 −8 meets conventional levels for genome-wide significance – for example, it is nominally significant at the 0.05 level after a Bonferroni correction for 2.5 million tests, and exceeds the 5×10 −7 threshold used by WTCCC in reporting “strongly associated” variants [26] .

Across 22 mutants, this analysis highlighted 300 nominally significant changes (Fig. 2a and Supplementary Table 3 ).

N1036K was nominally significant in all populations of the NIA ADSP WES dataset ( Tables 1 and S2 ).

p -values between 0.005 and 0.05 were also reported and considered nominally significant. 3.

An empirical P -value was generated by permutations (1000) for observing the number of SNP subsets with nominally significant concordance.

Additionally, we found that the effect sizes observed in CD4 + cells of patients with primary moderate hypertriglyceridemia (n = 39) matched in direction for 87% of the genes in primary moderate CD8 + cells ( P binomial < 0.001), and for 98% of the genes in the secondary moderate CD4 + cells ( P binomial < 0.001), of which 19% and 24%, respectively, were also nominally significant.

Of the six regions assayed, two showed a nominally significant decrease in the level of H3K4me3 in individuals with high compared with low AD neuropathological burden, at the genomic coordinates chr8:41519342-41519460 (primer Set 3: Figure 1 C, fold change [FC] = -0.30, p = 0.033) and chr8:41686181-41686328 (primer Set 5: Figure 1 E, FC = -0.22, p = 0.023), wi

Uncorrected p < 0.05 was considered nominally significant, whereas p _adj < 0.05 was considered confirmatory.

Metabolite values were analyzed in both baseline plasma samples and samples collected following the six-month dietary intervention to consider both metabolites that could predict the response to diet and those that changed in response to diet or weight loss.Eight metabolites changed over the intervention at a nominally significant level: D-pantothenic acid, L-methionine, nicotinate, aniline, melatonin, deoxycarnitine, 6-deoxy-L-galactose, and 10-hydroxydecanoate.

This means that they fail to validate when applied to independent data or may demonstrate only nominally significant predictive value (that is, they may predict outcome slightly better than chance).

In contrast, within the experiment, differences between the AngII and AngII/oxLDL treatments, while nominally significant and consistent with their hypothesis, generally were only 10-20%.

On the whole, we observed few lead SNPs located in those loci involved in IBD or its subtypes were nominally significant in Basque cohort (Supplementary Table S2 ).

Bi-directional MR analysis revealed four genes ( CLC , CCDC21 , S100A13 , and GCNT1 ) as nominally significant ( P mRNA→IgE < 0.05) causal regulators of IgE concentration without reverse causal effect ( P IgE->mRNA > 0.05), suggesting that individual gene transcripts that are associated with IgE concentration likely contribute causally to IgE regulation.

6 Prenatal SSRI Exposure and Child Brain Outcomes Nominally significant findings are reported in the Supplement .

Furthermore, the SNP showed nominally significant association with T2D in African-American cohort ( 11 ) and actually associated with mRNA expression in their muscle ( 12 ).

Though nominally significant, these associations did not remain significant after correction for multiple hypothesis testing.

We find that the statistically significant variation in social problems (and to a nominally significant extent, total psychopathology, externalizing, and attentional problems) across SCA groups is driven by higher elevations in groups carrying an extra Y- as compared to an extra X-chromosome.

These analyses have focused on identification of nominally significant case vs control allele frequency differences at several nearby SNP markers in multiple independent samples.

p -value = 0.022), and nominally significant when compared with ε4 (OR = 1.265, 95% CI: 1.010 to 1.585) (Fig. 5 c).

Results also indicated nominally significant and unanticipated under-representations of NF-κB and EGR2 response elements in promoters of genes upregulated in association with MDD, although these latter two findings would not attain significance under Bonferroni correction for multiple testing across the nine TFBMs analyzed.