“nominally significant”

P values < 0.05 and ≥ 0.00006 were considered to be nominally significant.

The Benjamini-Hochberg method was used for multiple testing correction in analyses resulting in nominally significant P -values, assessing significance at a false-discovery rate (FDR) less than 0.05.

Robust evidence was assigned when all methods performed showed nominally significant P values and directionally concordant effects.

When assessed in the subgroup of patients who were former smokers, itepekimab demonstrated nominally significant reductions in acute COPD exacerbations compared with PBO and improvement in FEV1.

A total of 34 associations were identified at the nominally significant level (P for SMR < 0.05 and P for HEIDI > 0.01) for IBD (Supplementary table 8).

percentage among the LL (18%) (unadjusted P value = 2.7e−06); most notably, this is the only disease category with a higher percentage of disease genes among the EL compared to ML and LL genes; (3) a higher percentage of skeletal disorder genes is found in ML set, although this association is only nominally significant; and (4) for the remaining disease categories, the frequency of disease genes among the EL genes shows values comparable to baseline or even lower, indicative of depletion of these disease categories among the EL genes (Fig. 3 c, Additional file 2 : Fig.

Moreover, for any retinopathy, there were several nominally significant associations with SNPs close to the ANK1 , SLC30A8 , MTNR1B , TMPRSS6 and HK1 loci.

In view of the number of immune subsets tested and the exploratory nature of these analyses, p -values were primarily interpreted descriptively; particular emphasis was placed on patterns that were consistent across related cell types and datasets rather than on single nominally significant comparisons.

While only 34 SNPs from the 13q33.3 association were nominally significant in the AGA-ALZAR samples, the occurrence of a unique AD-protective NAM variant in this region was suggested by haplotype analysis using the ADSP whole-genome sequencing data.

The two-tailed p -values for the t-statistic of the gene loss variable in each model was calculated and nominally significant proteins with a p -value below 0.05 were retained.

Nevertheless, we observed a nominally significant association between PRS 57 and almost all the features considered in the analysis ( Table 4 ).

The fact that the enrichment signals for many of the significant processes were still detectable after removing the known lipid genes from the GSEA analysis, suggests that some of the nominally significant associations in these pathways may represent true associations of more modest effects yet to be identified.

[ 33 ] demonstrated that Odoribacter had nominally significant heritability estimates (0.476), implying its potential role as a genetic carcinogenic factor for prostate cancer.

Furthermore, several nominally significant longitudinal associations did not survive FDR correction for multiple comparisons and should therefore be interpreted with caution.

In the replication phase or in the verification of replicability of the reported loci, the significance threshold was set at P <0.05, which is considered nominally significant.

Given that there was overall evidence of coevolution of members of the same protein complex and an excess of nominally significant complexes over the null expectation we applied the q -value method ( Storey and Tibshirani 2003 ) to investigate properties of the collection of statistical tests applied to protein complexes.

Nominally significant interactions were observed for sex, ethnicity, and IOP in several associations ( P for interaction < 0.05).

Functional annotation was carried out in FUMA [ 36 ] using all SNPs found within the independent genomic loci which were in LD of r 2 ≥ 0.6, were nominally significant, and had a MAF of 0.01.

Upon statistical analysis, the variant rs1540 on 16q23 showed a nominally significant association to BE/EA in the independent replication study (P replication = 0.019).

For CT, nominally significant negative associations were found between the right and left insula and PRS SZ ( β = −0.046, SE = 0.019, p FDR = 0.050, β = −0.039, SE = 0.018, p FDR = 0.065, respectively).

Although rs700635 is included on the list of potentially causative variants, it is not extremely well correlated with the index SNP rs13014235 ( r 2 =0.48) and rs13014235 retains a nominally significant BCC association signal when adjusted for the effect of rs700635 ( P adj =0.022, Supplementary Data 1 ).

Two plasma protein predictors CANT1 ( p = 0.01) and CD209 ( p = 0.004) were nominally significant, but did not survive FDR correction.

All 105 eQTLs were also tested for association with AD-risk in the FCA 3 DS case-control series, which detected nominally significant associations with eQTLs at the ABCA7 and AKAP9 loci ( Table S5 ).

When limiting the analysis to the most significant time interval for each gene–phenotype association and excluding HPO modifier terms that specify age of onset, severity, or specific quality of phenotypic features, 859 nominally significant associations were identified (Table S5 ).

For these lipid species, 677 SNP-lipid associations (involving 55 lipid species and 106 SNPs) were nominally significant in FinnGen, while only 76 associations were not.