“nominally significant”

Nominally significant associations are italicised.

DLK1 levels showed nominally significant increase in both patient groups compared to HC with no differences between BD and SCZ.

A p -value < 0.05 was considered nominally significant.

The initial gene-based test results in GLS2 in the discovery dataset were nominally significant in multiple subsets, resulting in its inclusion in the replication study.

Association of SAF with cardiovascular outcomes in CKD patients Among the CKD population, subgroup analyses comparing patients with ESRD to non-ESRD showed elevated SAF to be significantly associated with increased all-cause mortality in ESRD patients (HR 1.99, 95% CI 1.45–2.73, I 2 = 74.6%), but not in non-ESRD patients (HR 1.32, 95% CI 0.93–1.87, I 2 = 38.2%), with a nominally significant interaction (P for interaction = 0.087, Fig. 4 A).

The Bonferroni correction is too stringent, as a result, causal association with P < 0.05 was regarded as nominally significant. 2.5 MR sensitivity analyses Sensitivity analyses on different assumptions were performed including heterogeneity and pleiotropy tests after MR analysis to strengthen causal inference.

An exposure's causal effect was deemed indicative with a nominally significant false discovery rate (FDR < 0.05) in the IVW method, bolstered by consistent results across sensitivity tests.

p < 0.05 was considered nominally significant, whereas the level for statistical significance corrected for multiple testing (1 exposure × 26 outcomes = 26 tests) was set at p = 0.05/26 = 1.92 E −03. p < 0.05 is considered significant in heterogeneity and pleiotropy analyses.

From the UKB-derived GWASs of plasma proteins, nominally significant signals were obtained for HCM causing increased levels of NT-proBNP and NPPB ( Table S5 ), but these were nonsignificant after multiple testing correction.

A p value < 0.05 was considered nominally significant.

There was a nominally significant interaction between an individual’s degree of perimenstrual increase in GABRD expression (GABRD-AUCi) and cycle time, which correlated with a stronger quadratic shape of SI across the luteal phase ( Quadratic Interaction Est = −0.28, 95% CI = −0.54–0.01, p = 0.057).

Replication was sought using a nominally significant p-value of 0.05 or smaller and considering the effect direction of the triangulated analysis.

Treatment comparisons were exploratory, with p < 0.05 considered nominally significant.

Furthermore, 3 nominally significant interactions remained: mental distress, visiting a psychiatrist for mental health, and vitamin D ( Table e4 ).

Several additional correlations were nominally significant before correction, including positive correlations of THD with HbA1c and ALT, a negative correlation of CLO with age, positive correlations of IMI and DIN with SUA, and a positive correlation of ACE with AST (all p < 0.05) ( Table S4 ).

Yet, this association was only nominally significant, which—in addition to the absence of further oligogenic associations with ALS age of onset—results in a lack of clarity regarding the validity of this relationship.

Results: We found a few nominally significant associations between prenatal psychosocial stress scores and the maternal metabolome.

In the non-European cohorts, 139 associations (across 57 loci) reached nominal significance in UKBEAS, and 126 associations (across 37 loci) were nominally significant in UKBAFR.

A nominally significant effect in the expected direction was also found for rs7632287.

Similarly, in our study, only a nominally significant association was found for BMI and periodontitis, which attenuated to null in CAUSE and other sensitivity analyses.

The difference in PIIANP concentration of both groups at the 24 weeks FU was nominally significant but the p-value (0.0086) was slightly above the Bonferroni corrected significance threshold (0.0083).

Nonetheless, as these studies were generally underpowered, some understanding of biological processes behind ADHD and/or aggressiveness may emerge from the convergence of identified nominally significant loci.

CABG significantly reduced sudden deaths and deaths due to MI, with a nominally significant effect on fatal pump failure events.

However, the three nominally significant variants in the credible set (rs10767873, rs3925584, and rs963837) have previously been associated with kidney-related functions via GWAS in numerous ancestrally diverse cohorts, including Scr levels, glomerular filtration rate, and kidney disease [ 36 – 53 ].

In summary, we identify 16 GO terms that are nominally significant at the 5% level, i.e., their confidence intervals do not overlap with 0 (Table 1 ).