“nominally significant”

At a two-sided α = 0.05, five items were nominally significant: Com.Env3 inversely, and Com.Env6, Com.Env15–17 is positively related to BMI.

Of note is that for cfPWV and bfPWV there are even single SNPs with nominally significant causal effect.

Pathways with FDR < 0.05 were considered statistically significant, except for VEGF signaling pathway (FDR = 0.085) which is shown as nominally significant.

The FDR-corrected statistical analysis (Benjamini–Hochberg procedure) reduced the number of nominally significant findings from 37 to 34, with three borderline parameters (cobalt, mercury, beryllium) reclassified as nominally significant pending replication.

Yet, when subjects were stratified by AO subtypes, we found nominally significant evidence for an association of the GRIN2A rs1969060 variation and the GRIN2B rs1806201 variation.

A case–control association analysis of individuals with Asperger syndrome ( n = 174) revealed regions in 14 genes, including CYP19A1 , that showed a nominally significant association with Asperger syndrome [ 85 ].

Furthermore, we identified HLA DR+ natural killer cells (IVs = 3) as nominally significant with lipids and as potential mediators in the causal pathway between diacylglycerol (16:1_18:1) or various triacylglycerols and CAD (mediated effect: 0.007 to 0.013).

(2) European trios In the analysis of European trios considering G and interaction with four maternal environmental exposures individually using conditional logistic regression, 19 SNPs showed nominally significant associations with NSCL/P.

For interaction terms, we considered p -value < .05 as nominally significant.

However, none of these nominally significant associations survived multiple testing corrections before or after permutation.

6 , 7 After excluding these countries post hoc , there was a nominally significant effect of spironolactone on the primary outcome.

In conclusion, we demonstrate for the first time that SNPs previously reported to be associated with erythrocyte traits were nominally significant for an association with Hgb in children of European and Turkish ancestry with CKD.

After adjustment for baseline lumbar BMD and baseline TLK, the anabolic therapy coefficient remained nominally significant but did not remain significant after FDR correction (β = 3.478, 95% CI 0.042 to 6.914, p = 0.047; FDR q = 0.111).

In internal replication, all the newly identified loci were nominally significant both in East Asian and European populations (Supplementary Fig. 7b and Supplementary Data 25 ). rs35593046 ( CACNA1D ), rs7659823 ( EDNRA ), rs5823966 ( ZNF397 ), and rs1541596 ( CARM1 ) were much more frequently observed in the East Asian population (Supplementary Fig. 7c and Supplementary Data 25 ).

GLM analyses revealed nominally significant differences between the aADHD and HC groups in several domains, however, only the Rapid Visual Information Processing measures survived correction, indicating impaired sustained attention and response inhibition in the aADHD group.

Our cohort studies suggest that similar FOXP4 variants are likely to be a rare cause of plateau iris and ACG overall, although it is interesting that FOXP4 has a nominally significant association with iris/ciliary body disorders in Genebass.

We found nominally significant associations for all tested SNPs with ND measured by the Fagerström Test for Nicotine Dependence score; of these, 11 SNPs remained significant after Bonferroni correction for multiple tests ( p = 9 × 10 −4 ~2 × 10 −3 ).

Under strictly controlled in vitro conditions, a compound may cause a nominally significant reduction in cfDNA, MPO-DNA, H3Cit, or ROS levels.

86 , 87 In addition, although pegcetacoplan-treated patients with GA secondary to AMD in the phase III DERBY trial ( NCT03525600 ) narrowly missed the primary endpoint of reduction in GA lesions at Month 12 of the study, 86 longer-term analysis of patients has demonstrated that pegcetacoplan contributed to nominally significant reductions in GA lesion growth at Month 18. 87 Pegcetacoplan was also associated with a 73.3% reduction in proteinuria in five patients with C3 glomerulopathy in the phase II DISCOVERY trial ( NCT03453619 ) 88 and demonstrated preliminary efficacy in patients with cold agglutinin disease in the PLAUDIT trial ( NCT03226678 ). 89 It is likely that pegcetacoplan’s approved usage will be expanded to some of these conditions in the future, although the dosage and route of administration remains to be determined.

Dyslipidemia (measured through cholesterol, triglycerides, HDL, LDL) A prior study assessing CAD risk scores for 2,599 participants of the Dutch-Belgian Lung Cancer Screening Trial revealed nominally significant associations for genetic risk scores of low-density lipoprotein-cholesterol, total cholesterol, and obesity [ 48 ].

We regarded a locus as being fully replicated if the locus from the original GWAS study (defined as the genomic risk locus ± 100 kb) overlapped with a genomic risk locus in any of the latent factors ( P GWAS < 5 × 10 −8 ) or partially replicated if it demonstrated a nominally significant association with one of the latent factors ( P Bonferroni < 0.001 (that is, 0.05/47)).

In targeted gene-wise tests of 42 genes associated with EOC in previous genetic, epigenetic, and transcriptomic studies in blood, four genes were nominally significant among the metastatic cases in the present study.

Direction of effect matched across MCC-seq and MeDIP-seq data for all signals tested, and NGB (chr14:77736811) showed nominally significant results ( Supplementary Table S11 ).

We refer to P values between 0.05 and 0.0026 as nominally significant.

The age ( p = 1.10 × 10 −2 ) and renin ( p = 1.30 × 10 −2 ) showed nominally significant results but did not reach the threshold p value of multiple testing correction (adjusted p value = 0.05/6 = 8.33 × 10 −3 ).