“nominally significant”

As the associations we observed in the present study were nominally significant, it is possible that these associations are false positives.

The p < 0.05 was considered nominally significant.

Replication of nominally significant results from the multivariate analysis of Kiel-I was sought in the two other COVIDOM sub-cohorts.

While none reached significance in diff-ChIP enhancers after multiple test correction, all of the QTL types except CTCF bQTL were nominally significant (Fig. 4 a, top).

Four of them were nominally significant for TCR depth response at 8 weeks in the latter cohort (amino acids I at position 97, A at 152, L at 276, and T at 321, all variants belonging to the same LD block).

However, a direct role for the UBC gene in determining circulating VEGF levels was not identified and none of the variants within 60kb of the UBC gene were associated with circulating VEGF level even at a nominally significant level.

We also observed weak but nominally significant positive correlation between Eggerthella lenta abundance and fecal and plasma levels of LCA (ρ feces = 0.1, ρ plasma = 0.13) and DCA (ρ feces = 0.1, ρ plasma = 0.15), the products of BA dehydroxylation ( Fig.

However, rs2069827 was previously identified as nominally significant in a Dutch prospective cohort study of longevity investigating 102 SNPs in 16 genes; in this study, the T allele (which had a protective effect on depressive symptoms in our sample) was associated with increased longevity (Soerensen et al., 2013 ).

Local genetic correlation analysis, providing higher resolution of genetic overlap with mixed effect directions, revealed that 65% (18/24) of nominally significant correlations were positive between the traits (Fig. 2 C; Table S3 in Supplement 2).

20 None of the associations were nominally significant ( α = 0.05) in our data (data not presented) or in the GECCO (data not presented).

Multiple subgroup and disease-level comparisons were performed without formal adjustment for multiplicity, so nominally significant findings should be interpreted cautiously, with greater emphasis on effect sizes, 95% CI, and overall patterns of results.

We chose risk factors based on a minimal subset of nominally significant ORs within our training data as well as literature guidance. 3 4 7 9 11 12 14–16 For the susceptibility models without symptoms, we included a subset of exposure-related questions, based on the training OR analyses, as well as two demographic variables (age and sex).

Differentially expressed genes (DEGs) with nominally significant P -values (<0.05) and log 2 -fold (L2F) changes (>|0.2|) were mapped on KEGG pathways with pathview. 44 IL6 measurements in serum To investigate interleukin 6 (IL6) levels in PINK1 / PRKN biallelic and monoallelic mutation carriers ( n = 20, mean age ± SD: 52.9 years ±14.3 years, 9 females), venous blood was collected in serum tubes and processed within 1 h.

For statistical significance, we adopted a tiered threshold approach: (1) the P value of IVW method less than 0.05 was considered to be nominally significant results; (2) the P value was further corrected using the Bonferroni method and was set as 1.31×10 −4 (0.05/191/2, where 191 is the number of rsfMRI phenotypes, 2 represents forward and reverse MR analyses) for significant results.

First, the PRO endpoints were evaluated as an exploratory objective in PhALLCON, and no adjustment was performed for multiple testing, therefore the nominally significant results should be interpreted with caution.

At the model level (Figure 7a ), nominally significant group differences were observed for the repeat data and BrainSurfGCN, with above‐average performers showing higher correlation differences than below‐average performers; however, these effects did not survive FDR correction, potentially reflecting limited statistical power.

Meanwhile, we also found that OSA had nominally significant causal effects on 29 immune cell traits, including 13 positive causal effects (OR: 1.34∼2.02) and 16 negative causal effects (OR: 0.38∼0.75).

Across both models, only 18 of the 280 retinal-cognitive function associations were nominally significant.

In 3 of the 6 nominally significant bivariate associations described above ( ACE , F7 , ICAM1 ), the allele hypothesized to be protective against ACS occurrence was associated with early death following ACS, creating an apparent paradox.

We observed that M11 was associated with “Neuron development” and had nominally significant enrichment in iNeuron‐EV markers.

Moreover, depressive symptoms were a nominally significant predictor of FP performance beyond the variance this task shares with intelligence itself.

Although no associations survived FDR correction (all p _adj > 0.25), nominally significant correlations were observed between improvements in anxiety and sensory hyperresponsiveness and changes in multiple species.

p values less than 0.05 were considered nominally significant.

The dose-response across PLIKS levels at 20 years stayed positive but was no longer nominally significant.

Within these overlapping regions, we identified 12 novel independent signals, 9 of which were nominally significant in the multi-ethnic fine-mapping but none were included in their top order or putatively functional SNPs.