“nominally significant”

In total, 330 (76%) SNPs were significant in the larger disease or quantitative trait meta GWAS at a Bonferroni-corrected p value threshold of 0.05/432 = 1.16 × 10 −4 and 389 (90%) at a nominally significant p value (256 [59%] SNPs reached genome-wide significance).

For factor 9, there was also a nominally significant negative association with ASD PRS ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$p<0.05$$\end{document

None of the nominally significant SNPs in DIP2A have been previously reported in association studies of reading impairment/ability and here we show that they might have effects on verbal executive processing as well as reading ability.

When overall ANOVA was nominally significant, Bonferroni-adjusted post hoc pairwise comparisons were performed.

However, Brd1 +/− mice were characterized by nominally significant volume reductions in several, particular, sub-cortical brain structures.

For meta-analyses with nominally significant findings, the strength of cumulative evidence was graded based on the Human Genome Epidemiology Network (HuGENet) guidelines 46 ( Supplementary Table 2 ).

When comparing aspirin monotherapy versus dual antiplatelet therapy, a nominally significant interaction was observed for recurrent ischemic stroke ( P for interaction=0.04; Figure 3 ), but not for clopidogrel monotherapy versus dual antiplatelet therapy ( P for interaction=0.31; Figure S4 ).

Briefly, evaluation of excess significance was to compare the observed number of studies of nominally significant results (O) with the expected number of significant results (E).

Statistical analyses To align with our primary research objective (i.e., how infections might impact longitudinal changes in brain structure), and secondary research objectives (i.e., whether such infection-related brain atrophy can influence cognitive decline and molecular changes underlying dementia), a hierarchical gating approach was employed, whereby infections of interest for downstream analyses were first identified with discovery analyses of infection-related brain volume loss in the BLSA using a nominally significant p-value of 0.05 (although FDR-corrected results are also presented) [ 19 ].

The reverse direction MR result was also nominally significant and not significant after multiple test correction ( α Bonferroni = 0.004, p IVW = 0.0204, Supplementary Figs. 3 – 5 ).

Over 1,000 genetic association studies have been published, with largely inconsistent results, but a recent meta-analysis has identified 16 genes with nominally significant effects and an average pooled odds ratio of 1.23 [ 2 ].

If the causal estimates of more than three MR methods were nominally significant, gut microbiota taxa could be considered to have potential causal effects on blood lipids.

A nominally significant inverse association was observed with hemorrhagic stroke, in particular with intracerebral hemorrhage (OR, 0.65 [95% CI, 0.49–0.86]).

A recent study demonstrated that rs3851179 had a nominally significant main effect on hippocampal volume in healthy, young subjects [ 37 ], although negative findings have been reported in the elderly [ 39 ].

A raw P value of < 0.05 in our study was considered nominally significant.

We find nominally significant evidence for concordance between the direction of effect at previously reported osteoarthritis loci and the discovery analyses for hospital diagnosed osteoarthritis definitions ( Supplementary Table 6, Supplementary Table 7, Supplementary note ), indicating that a narrower definition of disease may provide better effect size estimates albeit limited by power to identify robust statistical evidence for association.

Although we observed only four nominally significant interactions between prenatal exposures and sex on obesity, we revealed a prenatal environment defined by specific levels of these exposures whose effect on obesity strongly changed between sexes, with a 93% reduction in obesity risk for girls in relation to boys (OR interaction = 0.070, P = 2.59 × 10 −5 ).

The insulin response after a solid meal was nominally significant, suggesting that semi‐chronic twice‐a‐day dosing of ulotaront might improve insulin dynamics in schizophrenia patients at high diabetes risk.

Validation of Lactobacillales mediation Though the mediation effect of the order of Lactobacillales was only nominally significant, it shows the strongest mediation potential in both datasets.

Under the default setting of the weighted gene co-expression network analysis (WGCNA) program 22 , the above 87,588 nominally significant CpGs ( P nominal < 0.05) identified in male AUD subjects were clustered into 21 modules ( Supplemental Fig.

Specifically, at 1.1 Hz, the ANOVA conducted on the first component of explained variance revealed nominally significant effects for the interaction between age and condition ( p uncorrected < 0.05 ).

Of the high-quality variants tested (approximately 270 independent tests performed), rs11898094 (and variants in strong LD with it, including rs58261427), as well as other intronic variants in low LD with rs11898094 were nominally significant, and results were directionally consistent ( Supplemental Table 6 ).

also suggested that the T allele was nominally significant related to GC susceptibility among Chinese population when compared with the rs920778 C allele [ 37 ].

CLCN7 was also nominally significant in the gene expression correlation analysis among maternal profiles ( N = 35), along with 11 other genes.

Nonetheless, neuronal tissues were consistently prioritised, and nominally significant regions, such as midbrain structures and spinal cord, have previously been implicated in restless legs syndrome. 51 At present, major concepts in the pathophysiology of restless legs syndrome address alterations in the dopaminergic neurotransmitter system and in brain iron metabolism, and are suppo