“nominally significant”

Further, CYP2B6 expression was significantly different between smokers and non-smokers, whereas methylation of cg25427638 indicated a nominally significant difference.

We observed sixty nominally significant correlations; none survived false discovery rate (FDR) correction (lowest q = 0.08) ( Table S3 ).

For example, a meticulous systematic review of fluoxetine versus other antidepressants concluded than even if some nominally significant results were seen in some comparisons, "the clinical meaning of these differences is uncertain, and no definitive implications for clinical practice can be drawn" [ 21 ].

An RNA LASSO model consisting of 25 genes was found to predict survival in PAH; 372 of the 507 top dysregulated genes from the whole blood RNAseq study were present in the lung tissue microarray study 44 and 161/372 (43%) were also directionally consistent; 41/161 (25%) genes were nominally significant and 26 met false discovery rate (FDR) corrected significance.

Overlap with ALSPAC Genes with an ALSPAC GWAS gene-wise p <0.001 were considered nominally significant, and will be referred to as “ALSPAC-nominal genes”.

Again, the interaction effect was nominally significant but did not survive the Bonferroni correction.

None of these nominally significant associations remained significant after correction for multiple statistical testing.

The nominally significant increased risk of hospitalization with COVID-19 in the QIMR cohort did not survive multiple-correction testing.

Nonetheless, most processes with nominally significant P values were those previously highlighted, which are associated with somatic events [26] , [27] ( Table S1 ).

For all analyses, two-sided p values less than 0.05 were considered nominally significant.

For the PolyPy PyPu mutations, although there is a nominally significant enrichment of DNMs in general, this does not show a significant skew toward high-pLI genes in our cohort.

When suicidal behaviour was defined as “suicide, MedDRA preferred term for suicide attempt or suicidal ideation, or the standardised MedDRA query for suicide/self-injury,” the unadjusted association is nominally significant, and the direction of the association is the same (OR: 0.57; 95% CI 0.33–0.97 per number of minor alleles) ( Table 3 ).

Features, nominally significant in either of these two models, were further filtered out if not matching the suggested metabolite biomarker candidates, first by MS (if, e.g., matching to an isotope instead of the main fragment) and later by MSMS by comparing fragmentation patterns to the Human metabolome database hits of the suggested biomarker candidates.

Abnormalities in measures of anxiety and appetitive behavior were nominally significant, but confounded by hyperactivity in the mutant mice–particularly after sustained handling, which may suggest either an anxiety-related aspect or perhaps feedback from disturbed sensory input from the vestibular system.

[ 29 ] quantified the activity of the enzyme telomerase in PBL and found a nominally significant decrease in telomerase activity in individuals with schizophrenia compared to unaffected individuals.

Nominally significant findings were found for GMV but not CT ( Table S9 ).

Specifically, 10 CpG sites showed lower DNAm levels among delirium cases compared to controls, and levels of difference were nominally significant between the groups as determined by t-tests.

We observed two nominally significant Reactome pathways with the genes with fold change ≤ 0.74 and P adj < 0.001: Glucuronidation and Biological Oxidations ( P adj = 0.04 for both pathways), and 17 enriched Reactome pathways with the genes with fold change ≥ 1.34 and P adj < 0.001 ( Figure 3B ).

A pairwise comparison between treatments in the period between days 7 and 14 indicated that the community structure of microbiotas resulting from fermentation with HPDI or LPDI did not differ significantly from one another, while almost all other pairwise comparisons resulted in nominally significant differences.

All except one gene ( MYO1G ) were detected with SKAT at the gene level significance threshold ( P = 1.25 × 10 −6 ), while at least nominally significant associations were observed for most genes with CMC (Supplementary Tables 9 , 10 ).

There was a nominally significant effect (p threshold < 0.05 = 0.019) for the thalamus, where we found a higher proportion of SNP alleles with a negative effect on brain volume (BETA < 0) and an increased risk for AN (OR > 1) than would be expected by chance.

Across all three eosinophil risk categories, no statistically significant between-group differences were observed at either timepoint, with the exception of a nominally significant finding in the high-risk category (≥300 cells/μL) at both 6 and 12 months; as these counts fell below the TriNetX privacy threshold and were reported as rounded values, no conclusions regarding eosinophilia trajectory can be drawn from these data ( 32 ).

Five of 6 other lead SNPs in the original analysis remained nominally significant.

, P -value < 1E-5) in only one scan were also nominally significant (with P -values on the order of 1E-3 to 1E-5), and had comparable effect sizes (odds ratios), in the other scan.

The CAV2 SNP rs13221869 was nominally significant for kidney transplant failure.