“nominally significant”

Although they found nominally significant associations between two single nucleotide polymorphisms (SNPs) in SLC1A4, the association did not survive controlling for the false discovery rate at level 0.05 and they concluded that this gene is not a major susceptibility locus in the Japanese population.

In addition, several nominally significant associations were noted with SBP and DBP among normotensives but none were statistically significant.

Ten loci showed nominally significant effects in the HUNT study in accordance with the expected statistical power (Supplementary Data 9 ).

The expression levels of FOS did not significantly differ between CSDS-resilient mice and control mice ( P =0.156; Table 1 ), whereas the expression levels of TRIB1 and CYR61 were nominally significant in CSDS-resilient mice, although their P -values were smaller than those in CSDS-susceptible mice ( Figure 1E ; Table 1 ).

Nominally significant p -values were reported for intervention effects on HbA1c.

3.4 Functional enrichment analysis Functional enrichment analysis was performed on all nominally significant metabolites from comparative analysis in normal and disrupted CR separately.

The excess of nominally significant association for flowering-related phenotypes has been eliminated, as would be expected if this excess were mostly due to confounding by population structure.

For that main analysis part, given the 7 MR estimates, a Bonferroni-corrected p value was set as .05/7 (.007), and p < .05 was regarded as nominally significant.

A third variant, rs7304841 (12p12), demonstrated a risk-increasing effect that reached FDR significance in marginal analysis (q = 0.035) and remained nominally significant in the joint model.

They discovered several nominally significant associations in the USMARC and the Duroc-Landrace F2 population, but no associations were consistent across populations.

P < 0.05 was considered as nominally significant.

However, only two of the associations, quinolinate and the ratio of quinolinate with the unnamed metabolite X—16397, remained nominally significant after including eGFR into the model.

In this paper, we aim to show that while individual modest genetic effects are difficult to ascertain, they can be collectively identified by combining nominally significant evidence of genetic association with current knowledge of biochemical pathways.

However, nominally significant results were seen for several subgroups including individuals outside North America, suggesting that the ‘Black African ancestry’ criterion is too broad and finer ancestral specificity, socioeconomic or other factors were more important.

Therefore, we performed enrichment analyses using nominally significant differentially expressed genes and proteins.

We compared these estimates by assuming an approximately normal distribution for ρ g and obtaining a Z -score for the difference in values; these differences were found to be nominally significant for both recurrent MDD ( P one -sided =0.023) and females-only ( P one -sided =0.044).

For the remaining 12 BMI-associated traits, only 3 nominally significant interactions were identified (between BMI and SNPs in APOA5 , LPL , and GCKR on plasma TG levels).

Three of these were identified as either genome-wide or nominally significant by GWAS and were affected by ethanol with a direction opposite those for AUD versus controls: MREG (melanoregulin), CASZ1 (castor zinc finger 1), and ST3GAL1 (ST3 beta-galactoside alpha-2,3-sialyltransferase 1).

We selected the exons in the top 20% of saliency scores for gene pathway enrichment analysis using the TopGO method [ 22 ] with the 1,079 analyzed genes as the background for comparison, and 43 Gene Ontology pathways had nominally significant p-values with the most enriched pathways related to GTPase activity and protein ubiquitination/degradation.

66 In addition, each of these genes was also nominally significant in a GWAS of neuroticism, with DRD2 being genome-wide significant in both phenotypes. 49 A comparison with a UK Biobank GWAS of self-rated health 22 showed that four of the five genes ( DRD2 , PRRC2C , C3orf84 and ASXL3 ) were significant across phenotypes.

Associations with P < 0.05 but P ≥ 6.84 × 10^−5 were termed ‘nominally significant.

For individual dietary components, each 1 SD increases in fruits (β −0.05, −0.08 to −0.02; P=0.001 for interaction), vegetables (−0.04, −0.07 to −0.02; P=0.002 for interaction), long chain (n-3) fats (−0.02, −0.04 to −0.001; P=0.037 for interaction), and trans fat (0.04, 0.01 to 0.07; P=0.015 for interaction) showed nominally significant interactions with the genetic risk score per additional 10 risk allele on change in body mass index.

Eight of 80 SNPs at T1D-associated loci showed nominal significance with DN or ESRD (including three at AFF3 that are in weak LD [r 2 0.030–0.046 in CEU] with the SNPs described here), while no CKD SNPs were nominally significant ( Table S9 ) [44] – [47] .

Across 118 meta-analyses, a total of 24 genetic variants in 16 different genes ( APOE , COMT , DAO , DRD1 , DRD2 , DRD4 , DTNBP1 , GABRB2 , GRIN2B , HP , IL1B , MTHFR , PLXNA2 , SLC6A4 , TP53 , and TPH1 ) showed nominally significant effects with average summary odds ratios of approximately 1.23.

Bioinformatic Analyses For protein–protein-interaction (PPI) network analysis, the software tool STRING (Search tool for the retrieval of interacting genes) v.11.0 ( https://string-db.org/ ) with standard settings was used to visualize networks among factors with nominally significant difference between HET and WT status, using three biological replicates [ 93 ].