“nominally significant”

SARS-COV-19 (COVID) positivity and vitamin D ( Fig 2E ) had the most substantial JE (0.55, i.e., 55% of models show a positive relationship, 45% a negative one), followed by systolic blood pressure and lisinopril ( Fig 2D ) (JE = 0.46), though the latter had fewer nominally significant outputs than the other associations tested.

For triglycerides, we highlight two genes that were study-wide significant in S-PrediXcan and nominally significant in Mendelian randomization and either transcriptome or proteome analyses.

Given the association of CGI shores with tissue-specific methylation [ 19 ], we extended our search to CGIs including +/- 1 kbp of flanking sequence, which yielded sets of nominally significant motifs [see Additional file 2 : Figure S1.A].

Of the 1200 possible variant and tissue combinations (25 variants x 48 tissues), approximately half showed nominally significant associations (Supplementary Data 4 ).

Moreover, we found 2,917 nominally significant pairs, a 3.4-fold increase in what would be expected under the null hypothesis of random overlap (expected 857.6 of 17,152 disease-principal component pairs at a 0.05 rejection rate).

Although previous GWAS reported a nominally significant sexual dimorphism for rs4646404 [ 7 ], we found no sex–SNP interaction effects in the linear regression analyses in the present study.

Complementary analysis of the functional capacity of the microbiome using the GMMs ( Figure 2 A right panel) revealed nominally significant associations for birthweight z-score and labor antibiotics at TP1, though these relationships did not remain significant after adjustment for multiple comparisons.

Nevertheless, the efficacy values presented are consistent with what was reported as significant (or nominally significant) relative to placebo in the respective pivotal studies. 9 , 10 Likewise, the safety profile, which was similar between patients who received placebo or benralizumab in the pivotal studies, 9 , 10 was consistent with what was reported for Year 2 in this study.

During the validation phase in the UK Biobank Chinese cohort, 12 novel SNPs were found to be nominally significant for lung function, including two in the TBC1D16 gene, one in the TAFA5 gene, and one in the MTHFD1L gene.

Thus, a nominally significant, yet plausible, interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels was observed.

Although the unstable repetitive sequence is linked with one of the three more commonly prevalent haplotypes, statistics point to a nominally significant likelihood that our observation reflects a founder effect rather than coincidence by chance.

In contrast, pathological RF positivity demonstrated only one nominally significant association at the Pearson level, which did not persist after BH adjustment, suggesting a modest or tract-restricted effect.

Only nominally significant associations were included (multiple comparison correction was not performed).

The nominally significant are summarized in Additional File, Supplementary Material, Table S3 .

34 For immune cell traits analyses, given the 731 MR estimates, a Bonferroni‐corrected P value was set as 0.05/731 (6.84e−5); for metabolites analyses, given the 1400 MR estimates, a Bonferroni‐corrected P value was set as 0.05/1400 (3.57e−5), and meanwhile P <0.05 was regarded as nominally significant. 35 , 36 RESULTS Strength of IVs This study examined the potential causal relationships between 731 circulating immune phenotypes, 1400 metabolites, and the risk of HF, using P <5e‐8 and F ‐statistics >10 as selection criteria.

All biomarker analyses were exploratory; two-sided p -values < 0.05 were considered nominally significant without adjustment for multiplicity.

A nominally significant inverse correlation was observed for CPLX1 and a trend towards inverse correlation for YWHAE ( Fig. 2 B), two phenomena that we had previously identified as synucleinopathy markers in mouse mutant midbrain (Gispert et al., 2015b; Brehm et al., 2015a ).

A nominally significant effect of our analyzed SNP rs6741418 on GLS gene expression levels in the small intestinal mucosa was observed in our celiac disease patients.

Consequently, some nominally significant results may reflect statistical noise rather than genuine treatment effects.

In order to further analyze nominally significant genes in the “TCR signaling pathway” and “cell cycle,” we performed unsupervised hierarchical clustering (Figure 5 D).

Nominally significant gene- and pathway-level results are reported in Fig. 5 and Supplementary Tables 15–18 .

Although potentially explained by chance, the nominally significant OR for BTNL-2 and ANXA11 may allow some detailed hypothesizing on the role of these genes in CBD development, especially considering the fact that CBD (in contrast to sarcoidosis) develops in individuals with a known trigger via an intermediate step of beryllium sensitization (Fig. 1 ).

The enrichment of nominally significant overlapping genes in both arterial tissues (including the aorta) and whole blood, and their directional consistency with ABI, highlights systemic regulatory mechanisms underlying peripheral arterial health.

This effect remained nominally significant using multiple imputation with missing not at random assumption as a sensitivity analysis.

We found a nominally significant association between HSV1 seropositivity and the left rostral anterior cingulate volume (Table 2 ) which is in line with those previous reports.