“nominally significant”

One SNP (rs7947391) showed nominally significant associations in three replication cohorts (Australians, Polish and Spanish).

We found a nominally significant correlation between scores for the nondominant 9HPT and the SDMT and TRAIL‐B scores, but the correlations were weak and should be analyzed in more detail in future studies before the significance of this finding can be assessed.

Including these nominally significant signatures present in controls would provide us some suggestive evidence of detection, though caution should be used for potential false positives brought by multiple comparison.

In terms of an association with cigarette smoking, SC had a nominally significant inverse association with smoking duration.

In our approach, one surrogate variable showed nominally significant differences between groups and were included in our models.

The TWAS revealed that 20 of these 28 genes had nominally significant associations with intelligence at the cis-regulated mRNA level, with 10 of these genes showing consistent directionality of effects on both mRNA and protein levels.

Combined QNTS and QLSCD sample As 4,028,157 polymorphisms were shared and the phenotypic distribution did not differ between the two cohorts (Mann-Whitney U test = 132,241.000, SE = 4,945.508, p = 0.925 and Mann-Whitney U test = 128,134.500, SE = 4,946.462, p = 0.356 for pain problems and anxiety symptoms, respectively), we merged the genomic regions for which we found nominally significant results in both the QNTS and QLSCD to achieve stronger statistical power and thus test the robustness of the previous findings.

A nominally significant monotonic trend was observed for serum N-dm-ACE, where increasing concentrations were associated with a reduced likelihood of achieving biochemical pregnancy and live birth ( p -trend < 0.05) (Fig. 5 B).

Preliminary analysis not including any covariates showed nominally significant associations between IgE to egg ≥0.35 kU/l and IgE to the egg component ovomucoid ≥0.35 kU/l and positive oral egg challenge result (p-values 0.028 and 0.028 respectively).

In two-sample Mendelian randomization with inverse-variance weighting as the primary estimator and other robust methods as comparators, we identified 524 nominally significant gene–cell type associations with ICH risk at an unadjusted P value less than 0.05.

Patients were slightly older, but the difference was only nominally significant for remitted patients.

For multiple testing adjustments, a Bonferroni-corrected P -value threshold was set at 0.05/5, while a P < 0.05 was considered nominally significant.

Nominally significant interactions between some patient subgroups and the effects of serelaxin on 180 days cardiovascular and all-cause mortality were noted but should be interpreted cautiously due to the number of comparisons and the low incidence of deaths in the subgroups at lower risk.

Pairs of variants showing nominally significant interactions in the LRT were further analyzed with generalized linear models.

31 Indeed, Cystatin C remained the most strongly associated with rDNA CN in a multivariate linear model including all blood biochemistry biomarkers related to renal function simultaneously, regardless of whether they appeared as nominally significant on their own ( Figure S16 A; this occurs both with and without C-Reactive Protein, a well-established marker of inflammation, as a covariate).

Post hoc adjustment for age yielded lower relative HRs with nominally significant results in favor of cinacalcet, as did the analyses that accounted for differential withdrawal of study drug and commercial use of cinacalcet in the placebo arm.

Seven risk variants of the mALPS-index demonstrated nominally significant associations with consistent direction of effect with the discovery results in at least one cohort, four of which reached significance after FDR correction (Supplementary Data 5 ).

Bonferroni correction was applied to account for the multiple testing, where P ‐value <.005 was regarded as statistically significant and P ‐value <.05 was regarded as nominally significant. 3 RESULTS 3.1 Characteristics of the study participants A total of 113 256 participants were included in the analysis, including 165 EOCRC and 719 EOCRA cases.

Sixty-six nominally significant associations were found of which 28 were highly significant (P less than or equal to 0.0001).

The initial nominally significant associations between the Mean(RMLD) and patellar cartilage volume failed to retain statistical significance.

Moreover, among the 203 proteins that were nominally significant prior to multiple testing correction, 30 proteins exhibited a monotonic trend across disease progression, with 25 showing a stepwise increase and five showing a stepwise decrease in their mean abundance from HC → iRBD → PD ( Figure 2 B, Supplementary Tables S4 and S5 ).

The analyses revealed dozens of genes showing nominally significant associations with both sarcopenia and osteoporosis in each examined tissue, of which around 70% exhibited consistent effect directions for the two diseases (Tables S50–S52 ).

We found nominally significant positive correlations between the BRIEF GEC and positive and disorganization symptoms endorsed on the SIPS ( Fig. 2d–f ), indicating that individuals with 3q29del and poorer EF experience more severe psychosis spectrum symptoms on average.

In total, 53% of white matter PVS risk loci showed nominally significant associations (27% after multiple-testing correction) in a Japanese population-based cohort ( N = 2,862; 68.3 ± 5.3 yr).

Among 39 polymorphic sites, 20 had significantly lower expression in strains with the insertion, 2 had nominally significant differences in the opposite direction, and 17 were not significantly different.