“nominally significant”

It is a Chi square-based test that assesses whether the observed number of studies with nominally significant results is larger than their expected number.

The GO term “synapse” was nominally significant only when the KNR L1 gene list from the cocaine population was input (Table 1 A).

Besides, among the association results from the only published GWAS in ALI [ 27 ], genes involved in neuron differentiation were also overrepresented among the nominally significant hits, including those encoding molecules implicated in neural and vascular functions ( S2 Table ), again being the only process overlapping with the results from the microarray studies in the sepsis animal model.

A shared overlap set of 69 variants were nominally significant and of a concordant direction of effect in both study populations; twelve of these variants had marked risk effects (Table 2 ).

Two vortioxetine doses were investigated because both 10 mg and 20 mg demonstrated nominally significant improvements in MADRS total score and response rate, and acceptable tolerability, in the secondary analysis of a randomized, placebo-controlled, multinational, 8-week, Phase 2/3 trial of vortioxetine that included Japanese participants with MDD. 16 After the treatment period, study drugs were withdrawn, at which point patients entered a 4-week safety follow-up period for the analysis of outcomes of adverse events.

In addition, we report additional protective variants at IL23R , and identify an excess of additional nominally significant variants in MUC19 , PTPN22 , and C1orf106 .

Within the regions of NR3C2 and CDH5 , which are two previously reported putative susceptibility genes for CSC ( 15 , 17 ), rs10519952 in NR3C2 ( P = 0.030) showed nominally significant association with choroidal thickness in our GWAS discovery stage ( SI Appendix , Figs.

Briefly, the variant nominally significant at the univariable model was censored in the SKAT-O variant count matrix and included as a covariate in the SKAT-O modeling.

Because the sample size was limited (although still among the largest of such studies in the field), we used raw p-value < 0.05 as threshold for nominally significant differential expression (supplementary Table 1 ).

However, working memory’s significant association with anorexia nervosa increased after the same adjustment, and it gained a significant association with schizophrenia as well as nominally significant associations bipolar disorder and anxiety.

15 However, the control group—who received non-optimised dorsolateral prefrontal cortex stimulation—also showed nominally significant, though less prominent, improvements in social outcomes.

This is so even if in some studies (mainly retrospective, post hoc or using predefined but nominally significant ‘secondary’ outcomes) it seems that the mortality rates are reduced by the achievement of certain targets or the use of certain drugs [ 56–61 ].

Despite most of our analyses suggesting a stronger contribution of maternal, than fetal common genetic variants to GWG, the one nominally significant variant that replicated was for a fetal variant that was related to total GWG.

All nominally significant results survived the FDR procedure.

AA isoleucine, apolipoprotein A1, and total cholines were not only associated with baseline kidney measures (P FDR < 0.05) but also showed stable, nominally significant association with incident CKD and decline.

Nominally significant associations were obtained for mismatch repair genes ( MLH1, MSH2, MSH6, PMS2 ) in all PC patients, however, variants in ATM, CPA1 , and PMS2 were only observed in CDKN2A wild-type PC patients.

We found more loci with nominally significant covariance with IBD (at p -value thresholds of .01 and .05) for both HADS scale models ( Supplementary Figure S10A ).

Cumulative effect of rs1801274, rs3818298, rs2736340 and rs4813003 on KD risk Next, we examined the cumulative effect of the 4 nominally significant SNPs by counting the number of non-risk genotypes associated with KD risk in each subject according to the potential inheritance models presumed by the results of dominant and recessive models from individual SNP analysis.

All the lead variants from these loci showed at least nominally significant association in the latest available data freeze from the publicly available FinnGen dataset (freeze version 10) for the ‘Body-mass index, inverse-rank normalized’ trait, suggesting that these single nucleotide variants (SNVs) represent valid hits (Supplementary Fig. 4 ).

We found one nominally significant association between maltreatment and levels of an inflammatory marker in the MDD case group, whereby, childhood maltreatment was associated with a reduction in circulating levels of serum amyloid A in adulthood ( F (1, 143) = 4.837, P = 0.029, variance explained, 3.3%).

A cut-off p value <0.02 was used to retrieve nominally significant SNPs.

The two studies that assessed interactions of DAT1 with birth weight reported nominally significant effects on the occurrence of conduct problems in children with ADHD in a case-only study (Langley et al., 2008 ) and significant G × E effects for a genetic index including DAT1, DRD4 , and DRD2 and birth weight on ADHD symptoms in a sibling sample (Jackson and Beaver, 2015 ).

One nominally significant estimate of heritability was uncovered attributing 41% of the variance in internalizing problem scores to the effects of all SNPs in the GWAS, showing that the CBCL-internalizing problem score has a significant polygenic component similar to DSM-based psychiatric disorders 6 .

p values < 0.05 were considered nominally significant.

Among these nominally significant probes, 77.9% (1410/1809) of the probes for CD4 + T cells and 82.5% (1520/1843) of the probes for CD8 + T cells showed lower methylation rates in the patients than in the controls.