“nominally significant”

Comparing to the background of random genetic variants in CEU in all of HapMap Phase II, 4 SNPs in AHI1 and 8 in GPR56 exceeded the 99th percentile with nominally significant P -values (Fig. 3 A and Supplementary Material, Table S1a ).

Any complication and acute kidney injury were nominally significant in the matched cohort, while only any complication remained significant after false discovery rate correction.

have previously reported a nominally significant association between this SNP and a narrow ASC diagnosis in family-based samples [ 27 ].

In the UKB data, interactions of rs161070 from the PEX3 gene and rs7176881 and rs117778159 SNPs from the EIF2AK4 gene showed nominally significant associations with ST.

We also observed nominally significant changes in PD and DLB with co‐existing AD pathology across the amplicon, but these did not pass multiple correction.

Analyses over the intervention period and the cumulative follow-up identified nominally significant intervention benefits related to breast cancer ( 5 , 6 ), CHD ( 7 ), and diabetes ( 8 ).

As for the Wnt agonist RSPO3, we found nominally significant lower levels in SCZ, and no significant differences in BD compared to HC.

Both scores of bone-mineral density (in the femoral neck and in the lumbar spine) are nominally significant, suggesting a protective effect for AMD in individuals having a higher bone-mineral density.

The LS mean change in acute medication use days showed a nominally significant difference from placebo starting at the first treatment period and persisting in the second and third treatment periods (Figure S3).

Although a nominally significant reduction in the secondary outcome of hospitalization for heart failure was observed with spironolactone, overall the results of the TOPCAT trial were neutral.

a nominally significant excess in at least one spring month (March, April, May), and/or a nominally significant reduction in at least one winter month (November, December or January).

In addition, several symptoms were reported as milder for LRRK2 G2019S carriers at FDR < 0.1: excess salivation, fatigue, problems eating, constipation, problems with handwriting, bladder control, and problems dressing (nominally significant) compared to the iPD group at a comparable time after symptom onset (Table 3 ).

In accordance with earlier reported diet-CRC association, three metabolites, reflecting fiber and wholegrain, and fruit and vegetable intake, showed nominally significant associations to decreased CRC risk, whereas one alcohol-related metabolite showed a nominally signification association to increased CRC risk.

While several markers were nominally significant at an alpha level of 0.05 (e.g. miR-155-5p for lung cancer), they were not significant following adjustment for multiple testing.

In the stage I association study of allergic conjunctivitis, we selected 5 SNP in the TEK gene with nominally significant p-values.

Results Association analysis in sorbs We observed nominally significant associations with disinhibition at the variant rs10232478 located in the 5′ untranslated region and the intronic SNPs rs1834150 and rs782881 (Table 2 ).

Although not achieving P adj ≤0.05, identification of the Th2 pathway ( P = 1.22x10 -3 ; P adj = 0.074; z-score -0.82) and Activation of Th1 and Th2 Pathway ( P = 1.32x10 -3 ; P adj = 0.074) as nominally significant canonical pathways is consistent with prior knowledge of immune responses to leishmaniasis.

Nominally significant baseline factors associated with a higher risk of any-CVD included the secondary versus primary cohort, older age, greater weight and BMI in women but not in men, smoking, longer duration of diabetes, family history of MI and type 2 diabetes, higher blood pressure and pulse, and higher total cholesterol, triglyceride, LDLc, and HbA 1c levels.

2015) (p,p′-DDE and T-NONA) was detected; nor did we observe the positive nominally significant association between PCBs and ASD outcome (Lyall et al. 2015) in our analyses parameterizing exposure continuously ( Table 1 ).

Results: Our findings reveal a nominally significant positive genome-wide genetic correlation between CAC and AD, which becomes non-significant after excluding the APOE region.

While nominally significant HLA associations have been reported, no study to our knowledge has reported unequivocal statistical significance or the dissection of the complex linkage disequilibrium (LD) relationships in the MHC.

The input data included nominally significant genes (p ​< ​0.05) for SMYD1 or skNAC KD vs.

SUPPLEMENTARY MATERIALS Supplementary Table 1 Comparison of gait parameters between CU individuals and patients with ADD across all gait tasks Supplementary Table 2 Comparison of demographics based on the presence or absence of SNSB data Supplementary Table 3 FDR-adjusted p -values for nominally significant findings in the primary analyses Supplementary Fig. 1 Comparison of cycle time measured by the Smart-insole and GAITRite.

Our results indicate that the individual SNP rs1176744 (Tyr129Ser) was nominally significant and a major haplotype formed by rs1176744, rs3758987, and rs4938056 in HTR3B showed significant association with the FTND score.

In AFFIRM, the differences in mean EDSS over 96 weeks and at Week 96 were both nominally significant in favor of natalizumab treatment versus placebo.