“nominally significant”

Thus, although nominally significant, these signals may be underpowered and should be regarded as exploratory pending replication.

Overall selectivity of KT777 knockdown ( KCNT1 downregulated at an adjusted P value ( P adj ) = 1.7 × 10 −34 ; 11 additional downregulated genes nominally significant at P adj < 0.05; Supplementary Table 5 ) was similar to that of RNase H-activating ASOs BIIB067 and HTTRx (targeting SOD1 and HTT , respectively) (Supplementary Figs. 1 and 2 ).

The haplotype analysis revealed several nominally significant associated haplotypes in spite of low frequencies.

By contrast, while the associations for D2S441– C1D , CSF1PO– TIGD6 , and FGA– PLRG1 are significant in the cumulative dataset, within subpopulations, we observed no significant or nominally significant correlations ( SI Appendix , Supplemental Table 2 ).

SKAT required 15FC × 10FNC to report nominally significant p -values, GSKAT required 20FC × 5FNC to report statistically significant p -values, FarVAT-CALPHA did not generate significant p -values unless we used the BLUP correction; FarVAT SKATO reported p -values that were significant at 15FC × 10FNC, and at 5FC × 20FNC if we used the BLUP correction.

(2011) in relation to urinary arsenic species and observed nominally significant differential promoter DNA methylation in 812 unique genes, of which the majority were hypomethylated compared with relative urinary arsenic metabolite species.

Although there was a nominally significant negative correlation between the increase in connectivity in the cluster and the ADAS-Cog scores, this correlation did not survive Bonferroni-correction for multiple comparisons (see Figure 6 ). 4.

In a study using the TEDS sample at age 7 ( Meaburn, Harlaar, Craig, Schalkwyk, & Plomin, 2008 ), an initial discovery stage based on “pools” of DNA from low- and high-reading-ability groups ( n = 750 in each group) identified 10 nominally significant SNPs that replicated in a second TEDS subsample of individually genotyped individuals.

Third, only nominally significant P values were obtained from ZFHX1B rs13382811 in longitudinal analysis.

Although this is only nominally significant, it is notable that these genes are in the 3rd percentile of schizophrenia associations genome-wide within UK Biobank.

A heatmap of the 100 top nominally significant differentially expressed genes (DEG) demonstrated visible differences between adipocytes in 3% vs. 5% gels ( Figure 3c , Table 1S).

A two-sided P < 0.05 was considered as nominally significant.

Enrichment analysis We performed enrichment analysis by submitting the full list of nominally significant DEGs to the KOBAS algorithm 37 .

In addition, the intersect between the nominally significant differentially expressed genes in both the striatal RNA-Seq and the LCM striatal neurone RNA-Seq data sets are presented for comparison in Supplementary Table 2 .

A single-allele p-value of <0.05 was considered to be nominally significant and included in the PARIS analysis.

Consequently, a total of 19 SNPs remained in the subsequent analysis In individual SNP association analysis, ADRA2A rs553668, DRD2 rs1124491 and SLC6A4 rs6354 were nominally significant at the uncorrected 0.05 significance level with adjustment for age and gender.

To further assess the relevance of driver meQTLs to cancer risk, we used them to predict breast cancer status alongside clinical covariates using the approach described by Elgart et al . 18 We first performed feature selection by LASSO on nominally significant driver meQTLs and available clinical factors (age, ancestry as represented by the top 10 genotype-derived PCs); LASSO regularization removed ancestry and some meQTLs.

ECM1 had consistent associations with genetically predicted SCAD across both data sets, which were statistically significant, whereas SPON1 was only significant in UKB, despite consistency in direction of association, which was nominally significant before correction for multiple testing.

Discussion Genes harbouring markers with only modest evidence of association (nominally significant but not reaching the genome-wide significance threshold) can be identified if they belong to the same biological pathway or mechanism; therefore, pathway-based approaches, which jointly consider multiple variants in interacting or related genes, might complement the most-significant SNPs/genes approach for interpreting genome-wide association (GWA) data on complex diseases [ 7 , 8 ].

Although several genes showed nominally significant associations with overall survival, the corresponding hazard ratios displayed wide confidence intervals, reflecting the limited sample size and small number of mutation-positive cases.

KEGG pathway analysis was performed on all of the nominally significant DMRs to identify pathways associated with stress.

None of the nominally significant associations remained statistically significant after applying the Bonferroni correction.

The nine nominally significant lipids showed opposite directions of change between the two comparisons (Fig. 2 D, upper panel).

Finally, uncorrected p values were reported with corrected values to improve transparency, but nominally significant findings should be viewed as hypothesis-generating.

In the RCT, nominally significant placebo-adjusted differences in LS mean change from baseline to end point on the ADHD-RS-IV were observed in GXR-treated participants, in both subgroups (prior MPH, −9.8 [95% CI −14.6 to −5.1], P <0.001, ES 0.85; stimulant-naïve: −7.6 [95% CI −11.8 to −3.3], P <0.001, ES 0.65).