“nominally significant”

In our analysis, several miRNAs were nominally significant, but none of these findings survived multiple-testing correction.

Amongst these six coding variants, two of them, p.L211P and p.W191X, showed nominally significant or suggestive association with risk of LOAD in the combined AA cohort.

Network identification The two miRNAs that that showed nominally significant association in the analyses were further analyzed using TargetScanS [8] to identify their predicted gene targets.

However, we found two compounds from the phosphatidylcholines (PC) class (PC(36:4) and PC-O(34:4)) with nominally significant lower levels in the patient group (before correction for multiple comparisons).

Previously reported associations of HCC in the context of ArC with variants of HSD17B13 rs72613567:TA (p=8.95×10 −3 ; OR=0.81 (95% CI 0.69 to 0.95) and APOE rs429358:C (p=5.44×10 −3 ; OR=0.74 (95% CI 0.60 to 0.91) were nominally significant in this study, but did not achieve genome-wide significance in the discovery cohort ( online supplemental tables 5 and 7 ).

A nominally significant association was observed for the interaction term for ID, which did not survive correction for multiple testing (Bonferroni correction for six independent tests: p -value threshold = .0083).

39 , 40 The four variables presented are the top performers, and even though the VI ordering is strong, the inclusion proportions are small, suggesting that no one feature is overwhelmingly dominating the prediction, even while the corresponding permutation p ‐values, which ranged from <0.0005 to 0.035, are nominally significant.

The trend is similar and nominally significant for other genotyped common SNPs in moderate linkage disequilibrium with rs4721453 ( S16 Fig ).

Therefore, following our main analyses, we tested whether robustly and nominally significant effects remained present while controlling for sex, SES, number of parents and mental health at age 11, and tested for potential sex moderation effects.

By applying Bonferroni correction, a P -value below 0.0042 (0.05 divided by 12 SNPs) was considered significant, while a P -value between 0.05 and 0.0042 was considered nominally significant.

Moreover, SNP heritability for schizophrenia, bipolar disorder, and major depressive disorder was enriched at Bonferroni-corrected significance in NeuN+ OCRs overlapping either fetal H3K4me1 sites ( Figure 5 ) or H3K4me3 sites, with nominally significant enrichments observed for ASD in NeuN+ OCRs overlapping H3K4me1 sites and for ADHD in NeuN+ OCRs overlapping H3K4me3 sites ( Table S3 ).

After further applying Bonferroni correction to this set of 2388 nominally significant ACE-associated variants at a p -value threshold of 3 × 10 −7 , which was previously found reasonable for exome-sequencing studies of rare variants [ 62 ], we identified 17 variants in 12 genes that reached exome-wide significance— Table 2 .

While a range of sociodemographic factors was analyzed, some associations were only nominally significant after correction for multiple testing.

Albeit only nominally significant, enrichment was found also in miRNA binding sites for 10 phenotypes out of 15.

However, when analysing family-based and peer-based interpersonal stress separately, few nominally significant associations emerged only for family-based stress with inflammation. 4.1 Interpersonal stress and inflammation Contrary to our pre-registered hypotheses, we did not find evidence supporting that cumulative, interpersonal stress throughout adolescence predicts DNAm indices of inflammation during late adolescence or young adulthood.

Secondary analysis on a single-CpG level revealed—although not withstanding correction for multiple testing—nominally significant associations with HAM-D change for CpGs 8 and 9 (for details, see Table 2 ).

Ten out of 13 SNPs were found to achieve nominally significant association in regression tests (Tables 1 and 2 , Supplementary Table 5 ), the remaining 3 SNPs included two SNPs ( SEMA4D rs45483393 and TMEM132C rs1683723) identified with exome sequencing but not replicated in a set of 849 samples and one SNP ( TBC1D22A rs1005241) with suggestive association in Adhikari et al.

A nominally significant trend was also observed for the healthy-vs-asymptomatic comparison in the near-bark compartment, but this difference did not remain significant after Bonferroni correction ( Table 4 ).

The strongest association at the gene level was with reduced expression of COL28A1 ( P corrected = 0.012), encoding a collagen that is predominantly expressed in developing neural tissue 19 .Consistent with this being a primarily early neurodevelopmental risk mechanism, a previous TWAS of ADHD using expression predictors from multiple adult brain regions found only nominally significant evidence for association with COL28A1 expression in two brain areas (amygdala and cerebellum; Supplementary Table 3 ) 20 .

In addition, the analysis involved multiple cytokines, time points and subgroup comparisons; although Bonferroni and false-discovery-rate corrections were applied, some nominally significant associations (notably the borderline 6-month IL-1α difference) did not survive correction and may represent chance findings.

To minimize bias and provide a biological context, we focused on both the top nominally significant functions and functions previously implicated in ASD, as shown in Table 3 .

There were nominally significant falls from baseline in serum TNFα, bone specific ALP, CTX and PTH in the probiotic group compared with placebo groups from baseline, analysed by ANCOVA, but no correction for multiple testing was applied.

Since the FDR correction resulted in no significant results, we decided to show only nominally significant results for WR1 vs.

Nominally significant higher expression of HTR1A and NPY2R genes in the placenta of depressed mothers has also been reported ( Edvinsson et al., 2019 ).

report genetic overlap with inflammatory bowel disease [IBD] by comparing the number of nominally significant single nucleotide polymorphisms [SNPs] in both phenotypes. 3 The most frequently cited environmental risk factors are medications, with non-steroidal anti-inflammatory drugs [NSAIDs], proton-pump inhibitors [PPIs] and selective serotonin reuptake inhibitors [SSRIs] most commonly implicated. 5–7 There have been no reported investigations of potential pharmacogenetic risk factors for microscopic colitis.