“nominally significant”

Next, to determine SNP level odds ratios (OR) case-control analysis was run on the SNPs that were nominally significant and independent after set-based analysis, using Fisher's exact test.

Patients whose depressive symptoms abated had nominally significant decreases in miR-1202 and miR-425-3p levels [ 35 ].

For each suggestively associated ROI ( p permuted < 0.10), we next selected the “truly associated” SNPs in a backward stepwise survival analysis until only nominally significant SNPs remained in the model.

TNRC6A in STAD and DICER1 in SKCM and UCEC (nominal P > 0.005), but these overmutations are only nominally significant.

However, and despite the low power for an association analysis, we do detect six nominally significant missense mutations in four genes that might be candidate variants associated with an increased chance of survival.

In feature analyses, we considered a Benjamini-Hochberg adjusted false discovery rate of q < 0.1 to be statistically significant and a P < 0.05 to be nominally significant. 42 All analyses were conducted in R v4.2.0 using the RStudio v2022.02.3 + 492 environment. 43 , 44 Results A total of 134 infants were included in either or both 6-week (n = 116) or 1-year analyses (n = 119).

In subsequent association mapping studies, several SNPs with nominally significant associations with T2D are mapped to or near TREH, UBASH3B, KIRREL3 and SNX19.

Table S3: Nominally significant associations between microbial taxa and clinical or demographic variables across taxonomic levels.

Among CpGs of selected antioxidant defense genes previously linked to air pollution exposure, 2 CpGs in catalase gene ( CAT cg03728580 and cg17034036, chromosome 11), as well as 1 in thyroid peroxidase gene ( TPO cg01385533, chromosome 2) were differentially methylated (FDR p < 0.05) (see 10 top significant CpGs in Table 3 and all nominally significant CpGs in Table S6).

Probands in our study with lower school performance were enriched for damaging de novo coding variants in both LoFi genes (OR 2.07; 95% CI: 1.3, 3.5) and DD genes (OR 11.6; 95% CI: 2.8, 107), although the former did not show any nominally significant effect after excluding variants in the DD genes.

GP also demonstrated evidence of suggestive causal association, with IVW estimates indicating increased odds of AD given higher GP levels (OR = 1.20, 95% CI = 1.05 to 1.38), and both HDL.D and XL.HDL.C demonstrated nominally significant associations in the negative direction (HDL.D: OR = 0.89, 95% CI = 0.80 to 0.99, XL.HDL.C: OR = 0.88, 95% CI = 0.79 to 0.99), though P values did not reach adjusted significance ( P > 0.009) ( Dataset S1 , Fig. 1 , and SI Appendix , Fig.

We extend their result with the observation of a similar pattern for less strongly associated SNPs that are nominally significant but do not pass genome-wide significance thresholds and hence are not formally associated with BMI.

A previous study reported 7 a nominally significant association with rs4833103 in the TLR10–TLR1–TLR6 region with MZL risk.

Treatment with an antibacterial agent excluding flucloxacillin showed a nominally significant difference between the groups.

When the p-value was between the Bonferroni-corrected value and 0.05, it was regarded as nominally significant, which was considered suggestive of evidence of association.

Observed variability in the density of nominally significant associations ( Figure 1 ) is largely explained by variability in host and virus sequences, for example in the hyper-variable region (HVR) of HCV in E2 protein.

Two of the three most frequently identified genes in recent exome-wide association studies in unrelated individuals ( TREM2 and SORL1 ) were significantly associated with proxy AD/dementia in this study and the third gene ( ABCA7 ) was nominally significant.

The majority of TFBS (35/40) are significant in one tissue, four TFBS are significant in two tissues, and one TFBS, E2F1 is FDR significant across three tissues and nominally significant in five tissues.

Heterogeneity between datasets was tested with a Cochran test and for nominally significant Q-values, a Han-Eskin random effects model (RE-HE) meta-analysis was performed with METASOFT v.2.0.1 77 .

Nominally significant reductions in the risks of death, acute exacerbation of ILD or death, hospitalisation for respiratory cause or death and absolute decline in FVC % predicted >10% or death were also observed with both doses of nerandomilast compared with placebo.

Although these variants also resulted to be nominally significant when analysing the other chips, they lost their significance after adjusting for multiple testing (see Table 3 ).

2 only report CpG-SNP associations that were nominally significant in the first phase of their study, we expect a bias toward increased validation rates.

The loss of significance for several nominally significant metabolites after FDR correction may reflect Type II error rather than a particular absence of differences.

Enrichment scores > 1.3 are considered to be nominally significant.

Replication In a published EWAS of lung function in ∼2,000 European ancestry participants ( 8 ), 12% of our significant CpGs were associated with any of the three traits (FDR, <0.05), and an additional 49% were nominally significant ( P enrichment for both < 2.2 × 10 −16 ) (Table E16).