“nominally significant”

Two-Sample MR Analyses Associations between retinal microvascular features and MRI-cSVD markers that were nominally significant in our observational study were examined with bidirectional 2-sample MR to investigate potential causality and directionality of effects.

Only nominally significant categories (false discovery rate (FDR)<0.05) were included for analysis.

GV improvements at 6–12 months were also uniform across most subgroups, although a nominally significant interaction was observed for AEs (P interaction=0.02), with patients without AEs showing slightly larger GV improvements (1.316 vs. 0.792 cm/year).

In GWAS meta-analysis of stage 1 cohorts, the minor T allele of rs12917707 at the UMOD locus, previously identified by GWAS to be associated with higher eGFR in cross-sectional analysis [ 14 ], was associated with an increase in eGFR over time at a genome-wide significant level (p=2.6×10 −14 , Table 2 ), and showed at least nominally significant, direction consistent association with all other analyzed phenotypes ( Supplementary Table 4 ).

For the replication stage, combined p -values were obtained using the Fisher test when SKAT-O p- values were found to be nominally significant in both EP and PPMI cohorts.

These nominally significant associations suggest that increased fluctuations amplitude in two occipital nodes could increase the risk for LBD (OR = 1.23, 1.18).

Despite the moderate sample size, we were able to observe nominally significant associations between exposure and DNA methylation, including in sex-stratified analyses.

Those associations remained nominally significant after controlling for education and upon adjustment for highest household occupational position and potential confounders.

The cell lines induced via EBs contained a higher density of Nestin-positive NSCs (significantly at passage 5) and after differentiation resulted in a higher density of total cells and a trend toward more MAP2-positive neurons (nominally significant at passage 2).

Conclusion While right-sided IEDs were associated with lower RAVLT-D performance, this represents a nominally significant finding in the context of multiple domains tested without correction for multiple comparisons.

We used 33, 8, 12, and 4 risk allele SNPs which were nominally significant in BMI, WC BMIadj , WHR BMIadj , and BF% GWAS results in JHS, to characterize individual variants’ association with BF%, SAT, VAT, and VSR ratio, respectively; each SNP represents an independent locus within the genome (based on linkage disequilibrium).

When we modeled FEV1 and FVC exclusively with height, the effect of height on CAD risk did not appear to be reduced by lung function (OR = 1.13, 95% CI = 1.10–1.16, p = 3.2 x 10 −17 , Fig 3E ), although the effects for both lung function measures were nominally significant at best (p FEV1 = 0.026 and p FVC = 0.052) Fourth, we created a restricted set of height genetic instruments that excluded variants nominally associated with FEV1 or FVC [ 24 ] (p < 0.05) to more directly compare between results from the published work suggesting lung function’s effect on height [ 5 ], and only retained variants present in lung function, height, and CAD GWAS.

No individual cortical region showed an association with left-handedness that survived statistical correction for multiple testing, although there was a nominally significant association with the surface area of a previously implicated region: the left precentral sulcus.

We report the overall p value (omnibus p value) based on collective conditional analysis and considered P < 0.05 as nominally significant.

Gene-based tests of aggregated rare variants yielded several nominally significant associations with KANSL1 , CNN2 , and TRIM35 .

P values < 0.05 were considered nominally significant.

It should also be noted that rs1983853 yielded a nominally significant association with type 1 diabetes in all of the cohorts but did not survive correction for multiple testing in the final validation attempt in the Toronto dataset.

In the overall study population, and in those considered to have cardiac involvement (based on the prespecified definition used in the post hoc APOLLO analysis), treatment with vutrisiran was associated with beneficial changes in NT-proBNP and a nominally significant beneficial change in stroke volume compared with placebo.

In contrast, a non-zero estimate from Mendelian randomization can be obtained despite only nominally significant genetic associations with the outcome at the locus.

We found that 11 out of 12 C4A replicated pQTLs were still nominally significant (Supplementary Data 2 ), which indicates minimal impact of HLA-DR-DQ genotypes on our reported pQTL associations for C4A.

The fact that the authors only demonstrated a nominally significant association between the more prevalent MC4R genotype group (22 carriers of the −178 A/C polymorphism) and surgical outcomes argues for an overall lack of statistical power in the study.

Eight SNPs showed nominally significant associations with PAD in type 2 diabetes (Table 2 ).

To refine the source of significant association between estrogen metabolic pathways and POAG even further among women, we report the nominally significant SNPs that were in any relevant genes in POAG overall, HPG or NPG (Appendix 1).

Both NEK1 and SOD1 were nominally significant in our Chinese sample, while TBK1 was not significant (Table 1 ), and the case-control frequencies of rare coding variants were similar to Europeans ( NEK1 1.8%/0.4% vs 1.9%/0.8%; SOD1 : 1.5%/0.2% vs 0.9%/0.1%; TBK1 : 1.2%/0.2% vs 1.4%/0.4%).

Results: While the primary efficacy endpoint was not met in the overall study population, post-hoc analysis showed a clinically relevant and nominally significant treatment effect for AM-111 0.4 mg/ml in patients with profound ISSNHL.