Only one of the twelve genes, APBB1IP , has a nominally significant p -value ( p = 0.0117).
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A nominally significant linear relationship was found for apple juice (p = 0.0117) signature.
Mendelian Randomisation In two-sample MR analyses, we identified nominally significant inverse associations for tumour necrosis factor ligand superfamily member 13 (TNFSF13) with both AD (β = −0.094, se = 0.04, p = 0.012) and ACD (β = −0.104, se = 0.04, p = 0.013), and for interleukin (IL)−17D with ACD (β = −0.071, se = 0.03, p = 0.032; (Supplementary Table 9).
Although there was no evidence for differential ‘epigenetic aging’ in dup15q patients compared to controls in either cortical region (PFC: P = 0.06, TC: P = 0.45), there was a nominally significant association in CB ( P = 0.012) with dup15q carriers characterized by decelerated epigenetic aging compared to controls.
In this set, we identified nominally significant association between a rare haplogroup, E1b1b1c, and prostate cancer in stage I ( P = 0.012, OR = 0.51; 95% confidence interval 0.30–0.87).
The top SNP in the Jordan analysis, rs6134031 demonstrated nominally significant association with T2D in the WTCCC cohort ( P = 0.012) and the same direction of effect ( Table 2 ).
Differences between HSIL and cervical cancer were nominally significant ( p = 0.0120, q = 0.0717), whereas comparisons among non-cancer categories (Normal vs.
The SNP, rs6134031 in the Jordan analysis, demonstrated a nominally significant association with T2DM among the Europeans ( P =0.012) and the same direction of effect.
Although this pattern is in line with changes in BMI discordance being related to changes in smoking status of twins, the difference in smoking status over time in converging pairs was nominally significant only (p=0.012), and a similar trend of quitting smoking was noticed among the leaner twins from pairs of who were still BMI discordant at follow-up ( Supplemental Table 2 ).
Comparing the minor allele with the maximal allele of the SNP rs12134493 revealed a nominally significant correlation between nausea/vomiting and the MA subgroup (OR = 41.058, P = 0.012) (Table 6 ).
However, there was a nominally significant inverse correlation between the change in RHI values and the change in CIMT relative to baseline (Spearman correlation coefficient ρ = −0.268, p = 0.012; Figure 5 ).
Notably, we did not identify any association with Parkinson’s disease, and the association with schizophrenia was only nominally significant in the study that jointly analyzed schizophrenia and bipolar disorder (OR = 1.024 [1.009, 1.039], p = 0.012).
However, we found a nominally significant interaction association between PSS:NICU scores and intervention group for PPQ (interaction β=-1.18, 95% CI: -2.10, -0.26; p = .012; Table 3 ).
We found a nominally significant enrichment with SC.M4 (OR = 2.52, P = 0.0124).
All P values were two-tailed, P < 0.05 was considered nominally significant, and P < 0.0125 (Bonferroni correction P = 0.05/4) was considered a significant association.
Comparing the CETYGO score against the deviation between chronological age and epigenetic age predicted with the Horvath multi-tissue clock [ 35 ], we found a nominally significant positive relationship (coefficient = 23.5, p-value = 0.0129) highlighting that samples with inaccurate cellular deconvolution have a larger differences between epigenetic age and chronological age ( Figure 6 ).
In the large-scale GWAS of Japanese, rs12702634-C demonstrated nominally significant increased risk of ILD in general populations (OR=1.25, 95% CI 1.05 to 1.49, p=0.013; online supplementary table 7 ). 17 No association with any smoking behaviours was observed (p>0.18). 18 The RA-ILD risk variant of rs12702634 was located in the intron region of RPA3 and UMAD1 ( figure 1B ).
Overweight/hyperphagia were more common in individuals carrying LGD variants compared to carriers of missense variants with a nominally significant P -value [ Table 1 , chi-square test, 46% versus 18% ( P = 0.013)].
In our study, CR1 plasma protein levels had a nominally significant association with incident delirium ( P = 0.013).
The additive model retrieved a nominally significant difference in the same component (IC29), which however did not survive correction for multiple testing ( F 4,533 = 4.35; P = 0.013; and P FDR = 0.239).
In benign tumors, nominally significant correlations were observed between D and K trans (r = 0.621, p = 0.013) and between D and iAUC (r = 0.615, p = 0.015).
The overall pairwise genetic correlations between LAM and FVC, and PEF, were nominally significant and negative: r=−0.074, 95% CI −0.04– −0.10, p=0.013; and r=−0.10, 95% CI −0.05– −0.15, p=0.029, respectively (supplementary Table S2 ).
Exploratory analyses did show an effect of treatment on temporal lobe atrophy that was nominally significant (p=0.013); however, this finding will require replication.
Only one of these 15 SNPs (rs2815752 in NEGR1 ) was found to have a nominally significant association with PCOS (χ 2 = 6.11, P = 0.013), but this association failed to replicate in the case-control study.
Single marker association tests provided three nominally significant results: effect of rs6090378 on FTND score ( p = 0.013); and effects of rs3787138 and rs3787140 on MNWS score variance were significant but not robust enough for Bonferroni corrections ( p = 0.021; p = 0.026, respectively) ( Table S1 ).