“nominally significant”

A nominally significant SNP for the chr5q14 locus (rs3852188; P =0.01) was found in the MRI-confirmed lacunar stroke data set, but the effect was in the opposite direction.

Genes or splicing events that are nominally significant at p < 0.01 for SNP heritability ( cis - h g 2 ) are used for training predictive models (Supplementary Figure 3 ).

BMI effect on UEC was nominally significant with directional concordance with that in Japanese (β = 4.04 × 10 −3 , P = .010 in IVW analysis). 4.

We conducted a MR analysis and found that there was a nominally significant association of GDF15 with an increased risk of Alzheimer's disease (IVW: OR: 1.12; 95% CI: 1.027–1.220; P = .01).

Male patients with schizophrenia had larger right Hb than healthy male participants but this analysis was only nominally significant at p = 0.01, uncorrected for multiple comparisons.

There was a nominally significant ( P = 0.01) association between TPO positivity and the PTPN22 R620W variant (rs2476601).

Results were considered significant for p -corrected < 0.05 and nominally significant for p < 0.01 and p -corrected > 0.05. 3 Results Sample characteristics are presented in Table 1 .

In models adjusting for cigarettes-per-day, we confirm the association between rs16969968 and lung cancer (p<10 −20 ) and observe a nominally significant association with COPD (p = 0.01); the other loci are not significantly associated with either lung cancer or COPD after adjusting for rs16969968.

Nominally significant association was also found for SNP rs7174755 in ITGA11 (integrin, alpha 11) in the combined ISPC+AMPS sample ( P =0.010 for association with %ΔHRSD; P =0.025 for response).

At the 50% threshold, the difference remained nominally significant ( Figure 3 E, p = 0.0104) but did not meet the Bonferroni-adjusted criterion.

Causal Effects of Redox Regulatory Drug Targets on Psychiatric Disorders According to a significance threshold of p < 5.78 × 10 −6 for the eQTL level and p < 1.49 × 10 −4 for the pQTL level, genetic variations in the vitamin C target (cofactor, OGFOD2 in cerebellum, OR = 0.784, 95% CI = 0.715–0.859, p = 2.14 × 10 −7 ) and the melatonin target (agonist, RORB in cerebellum, 1.263, 95% CI = 1.167–1.368, p = 8.80 × 10 −9 ; additionally, there were many nominally significant results which could confirm the above results: hypothalamus, p = 1.04 × 10 −2 ; putamen basal ganglia, p = 4.40 × 10 −3 ) were significantly related to the risk of SCZ.

Testing for heterogeneity of the effect of metabolizer status on sexual problems across these two ancestry groups yields a nominally significant result (Cochran’s Q = 6.55, df=1, p = 0.0105).

Furthermore, all of the four EHOA loci are within tissue-specific regulatory regions for vascular/endothelial cells which we estimate is 2.8-fold higher than expected by chance alone (expected overlap=35%; 95% CI 0% to 75%), but, as we tested for enrichment within 16 different tissue-specific groups, 23 the enrichment was only nominally significant (p=0.011, online supplemental table S9 ).

Among the secondary strata, only the absence of chronic liver disease ( p = 0.001) survived a conservative Bonferroni threshold of 0.006 for the family of secondary tests; the age ≥65 contrast, though nominally significant ( p = 0.011), did not.

A similar picture emerged for the analyses with the number of different NLE ( Figure 2D ): none of the effects reached the adjusted level of significance, all p ≥.221, all , and only the main effect of the sum of different NLE was at least nominally significant, F (1, 443)=6.59, p =.011, ( Figure 2E ). 5.2.2.

For Braak stages, point estimates ranged from r = ‒0.52 (DFC × MKI67) to r = +0.19 (STG × TPT1), with the strongest nominally significant correlation observed in AnG across all microglia ( r = ‒0.38, p = 0.011).

Three subgroup comparisons showed a nominally significant interaction with treatment assignment; glargine may have been modestly more effective in participants with higher waist-to-hip ratios ( P = 0.011), greater grip strength ( P < 0.001), and moderate use of alcohol ( P = 0.029).

We also performed overlap analysis with an eQTL mapping study that identified four reQTL in 1,25D treatment in peripheral blood from African Americans and found that rs3848646- LCCR25 had nominally significant fastQTL p-value in 1,25D (p = 0.011) but not in EtOH (p = 0.228), suggestive of replication.

Analysis of amygdala PGS yielded nominally significant associations between the PGS for amygdala volume and PTSD (OR = 1.15, p = 0.011).

Although we found three nominally significant PRS SCZ × IMD interactions ( P = 0.011−0.031), none of these interactions survived at the Bonferroni-corrected P < 6.94 × 10 −4 (Supplementary Table S15 ).

Subgroup Analysis after Stratification into Hp Subtypes Five SNPs, including rs138753053, rs56823384, rs145397166, rs10503670, and rs76507772, showed suggestive or nominally significant associations for developing incidental events of cognitive impairment after SAH cognitive impairment in patients with Hp2-1 and Hp2-2 (5 × 10 −7 < p < 0.011) ( Supplementary Table S2 ). 3.4.

The SNP was nominally significant in the discovery meta-analysis ( p = 0.011; Table S11 ); however, most studies reported a positive effect of the C allele– opposite to that reported by Nicolaou et al.

However, medial gastrocnemius thickness showed a nominally significant association with the G_carrier genotype (β = 0.371, p = 0.0112; FDR-corrected p = 0.1683), suggesting a potential link between this genotype and muscle architecture in specific regions ( Table 7 ).

A nominally significant association was found between a variation in FKBP5 and PTG that did not survive correction for multiple testing (rs1306780, p = 0.0113).

There were no significant associations in the zero part of the Hurdle model for all metabolites analyzed. Second, the pathway enrichment analysis of 76 metabolites that were successfully matched to terms of the SMPDB database resulted in two nominally significant pathways: fatty acid biosynthesis and α-linolenic acid metabolism ( P = 1.16e −2 , P = 4.62e −2 ) ( Figure 4 ).