“nominally significant”

The proportion of A) nominally significant gene sets across fifteen cancer datasets and B) significant gene sets after correcting for multiple testing using the BH procedure.

However, the parameter estimates for the top five hits were mostly unperturbed and retained at least nominally significant p-values (< 0.05); in the case of cg16658191 and cg25578728, the magnitude of the associations became stronger after cell-mixture adjustment.

Additionally, 22 SNPs including C8B rs2281598, C8B rs72670362, C8B rs2269113, C8B rs582317, C8B rs614020, C8B rs2236217, TRAIL/TNFSF10 rs231987, FKBP5 rs9357201, FKBP5 rs2766533, FKBP5 rs9348981, SFRP1 rs17574424, APOA4 rs5104, APOA4 rs5100, APOA4 rs5092, APOA1 rs7116797, LGMN rs4904981, LGMN rs1242108, LGMN rs1015033, LGMN rs68062833, LGMN rs1242102, MFG-E8 rs10859, MFG-E8 rs17202544, MFG-E8 rs555006940, MFG-E8 rs2271715, and ANGPTL4 rs2278236 showed nominally significant association with TN (p for all < 0.05), and none of them remained significant after Bonferroni correction (as shown in Table S1 ).

No Apparent Contribution of MICA to Psoriasis Risk MICA variants demonstrated nominally significant associations with PsV, PsA, and PsC risk (the lowest p value, p omnibus = 2.2 × 10 −180 , was at MICA amino acid position 298 for PsV-affected versus control individuals; Table S2 ).

Taken together, these data demonstrate that MEVA identifies a robust set of candidates with the highest biological relevance, and that this signal of cross-cohort consistency extends to a wider group of nominally significant genes.

This has spurred a number of re-analyses of GWAS for psychiatric disorders that explore whether functionally relevant genetic variants maybe be over-represented among the nominally significant associations and whether this overlap could highlight specific pathways relevant for the disease.

Notably, DHRS9 has two transcripts within the nominally significant transcripts identified by the SKAT test, increasing the credibility that this gene shows a true trans -effect.

Results with uncorrected p -values below 0.05 but above the Bonferroni threshold were reported as nominally significant.

The investigation of copy number variations of the long (L) and short (S) forms of C4A and C4B in Europeans has shown a nominally significant association between C4BL and TD severity ( Zai et al., 2019b ).

Several miRNAs had a nominally significant p value in the normalized datasets.

One of them, the rs4321351 located in the PID1 gene, was nominally significant in the replication sample although it did not survive multiple testing correction.

Compared with CON group, the pooled intervention group had significantly lower systolic and diastolic blood pressure, insulin levels, HOMA-IR, and higher HDL-C at 6 years ( table 3 ) and a nominally significant decrease in 2-hour glucose from the baseline.

Interestingly, two of the candidate genes, namely PDE2A and PIK3C2B , were reported with nominally significant P -values for the association with NAFE in the Epi25 collaborative, the largest WES study in epilepsy to date. 38 While we did not find any additional URV in PDE2A , two heterozygous PIK3C2B URVs were identified in FE cases: a stop-gain p.Q1533* variant and a missense p.I1544 M variant in the C2 do

This effect is consistent with a nominally significant association between decreased NF1 subcutaneous adipose expression and decreased endometrial cancer risk in our recent TWAS. 22 NF1 encodes neurofibromin (NF1), a large multifunctional tumor-suppressor protein that is involved in several cell signaling pathways and regulates many cellular processes such as proliferation and migration. 28 NF1 is also associated with neurofibromatosis type 1 (MIM: 162200 ), a Mendelian disease characterized by fibromatous skin tumors.

Each of the 4 CNV set's candidate genes contribute to each of these enrichments with many sets nominally significant individually ( Table S7 ).

We should also bear in mind that most associations were nominally significant and lost significance after correction for multiple testing.

Other signals of metabolic and cardiovascular disorders (e.g., hypertension) were attenuated yet remained nominally significant ( Fig 2C and S4 Table ).

Furthermore, polygenic risk score (PRS) analyses are based on the premise that hundreds, or even thousands, of loci contribute to the inheritance 1 , 46 , 47 , and cross-inheritance 48 of psychiatric diseases, but in PRS, it is unclear which of the nominally significant SNPs represents a contributing locus based on the statistical criteria by which they were selected.

p values of <0.05 before Bonferroni correction were considered as nominally significant.

Factors found to be nominally significant in exploratory univariate statistical analysis were included in the binary logistic regression model to determine the significant contributors to the failure of SE.

Moreover, nominally significant Visium sex-DE observations were resolved into significant, cell-type-specific sex-DE using Xenium; for example, MC4R showed only nominally significant sex-DE in the entire VMH but became significant at the cell-type level in CRHR2 -expressing neurons of the VMH.

In the correlation analyses, we found that the SAT bulk expression of the lncRNA, AC002066.1 , was significantly positively correlated with the adipocyte diameter in a BMI-dependent way as a significant correlation was observed in the lower BMI twin siblings from each BMI-discordant MZ pair (adipocyte diameter: Spearman’s rho = 0.55, p adj = 0.0023) ( Figure 5 E; Table S13 ), while the higher BMI twin siblings from each BMI-discordant MZ pair showed only nominally significant p values ( Figure 5 D; Table S13 ).

Because a large number of statistical tests were performed, particularly in the co-occurrence and SNP-related analyses, and not all exploratory analyses were adjusted for multiple comparisons, some nominally significant findings may reflect false-positive associations.

In contrast, we did not observe nominally significant associations at the other previously reported loci in our cohort.

Within each database, empirical p < 0.05 was considered nominally significant. 2.8.