“nominally significant”

We tested these genes on an independent dataset of 4,877 cases and 6,203 controls, HIST1H1E showed nominally significant (Supplementary Table 3 ).

Efficacy Ratio to Baseline of UACR Over Time Finerenone led to a greater reduction in UACR from baseline to month 4 that was nominally significant versus placebo, irrespective of concomitant SGLT-2i and/or GLP-1RA use at baseline ( Figure 1 ).

Furthermore, they did a meta-analysis of 818 genes combining the PGC-SCZ2 and iPSYCH samples and revealed 104 nominally significant and nine significant genes, confirming the involvement of the nuclear-encoded mitochondrial genes in schizophrenia [ 115 ].

Although KLRG1 expression showed a nominally significant regional difference, this association did not remain statistically significant after FDR correction (q = 0.17).

This, most importantly, is due to the fact that if, against the odds, an underpowered study produces a nominally significant finding, it will overestimate the results meaning that the reported effect size is exaggerated compared to the population value ( Colquhoun, 2014 ; Ioannidis, 2008 ).

The association of rs11203152 with TMPRSS2 loss was nominally significant in ovarian cancer (OR ovarian = 4.87; Q ovarian = 0.11; Supplementary Fig.

Twelve analyses yielded nominally significant effects.

29 ), except batch and brain bank, as there were nominally significant (although not passing Bonferroni correction) confounding effects between batch, brain bank, and dup15q diagnosis for this subset of data 9 .

[ 41 ], suggested a nominally significant association.

In summary, the main findings of our study were thus a weak but nominally significant association of a block of polymorphisms located at the 5′ end of the IGF1 gene with breast cancer risk, particularly among women younger than 55 years, and an association of polymorphisms located in the 5′ region of IGFBP3 with circulating levels of IGFBP-3.

Further segmentation into unilateral subregions identified nominally significant cortical thickness reductions within regions from both the right and left hemispheres, predominantly in the right hemisphere (Table 2 ).

In all analyses, a q-value < 0.05 was considered statistically significant and a p-value < 0.05 as nominally significant.

Cumulative analysis of significant correlation differences between cases and controls for eliciting dysregulated biological coordination within and between pathways To test the hypothesis of dysregulated biological coordination in response to pathophysiological stimuli, we computed the observed number of nominally significant correlation differences between cases and controls, i.e. .

However, the differences between female and male SNP‐r g s were only nominally significant for both traits and did not survive correction for multiple testing emphasizing the need for larger sample sizes to examine sex differences.

Moreover, although we have found a nominally significant interaction between the FTO polymorphism and the aggregate score and folate intake in determining fasting plasma glucose concentrations, we cannot rule out the possibility that, as this is a secondary hypothesis and we have not corrected the P-values for multiple comparisons, the association obtained represents a false positive result.

Overall, top regulated DEPs for PTSD have significant or nominally significant changes in MDD, especially in DLPFC.

There was also a nominally significant difference between cases and controls in the allele frequency of IL17A rs4711998.

Association in non-diabetic AR AAs was nominally significant but opposite in direction.

Linear regression analysis showed weak, but nominally significant associations between ORs for nausea and reductions in HbA1c, FPG and body weight (Figure 3A–C ), as well as between ORs for vomiting and reductions in body weight (Figure 3F ).

Overall, 17 of 77 cALT SNPs were directionally concordant and nominally significant in both the imaging and biopsy cohorts.

We compared our DEG results to a partially overlapping smaller dataset ( n = 10–11 per diagnostic group) 26 and found moderate overlap in the number and direction of nominally significant DEGs with both our PTSD (61.4%) and MDD (72.7%) cohorts across cell types (Extended Data Fig. 3f,g ).

Moreover, 19 edges showed nominally significant gender differences in association strength, further suggesting the presence of gender‐specific pathways of symptom co‐occurrence.

Results Nominally significant MWEIS association for traumatic injury in control participants versus participants with rMDD was associated with CpG sites at the first exon, 3′ untranslated region, and exon boundaries and in the oxytocin-signaling pathway.

There were nominally significant interactions between gene pairs.

In the stratified analyses, all identified associations remained at least nominally significant ( SI Appendix , Tables S15–S18 ), with several associations showing substantially weaker signals, possibly due to the reduced statistical power resulting from the smaller sample size.