“nominally significant”

It is interesting to note that the base GWAS reported a nominally significant genetic correlation between schizophrenia and AD 7 .

Associations that are nominally significant in each of the two independent Celtic and Slavic GWAS and that increase in significance in the combined Celtic and Slavic GWAS are considered to be replicated in two independent subcohorts, that is, Celtic and Slavic genetic profile populations.

Among 6 DMPs identified in the discovery sample, 3 DMPs, cg07839457 in NLRC5 , cg05439368 in TRIM69 , and cg05349042 in BCL9 , were nominally significant (Table 2 ).

Lastly, given the nominally significant one‐tailed tests in the per‐protocol and exploratory analyses, future research should aim to collect larger samples to replicate the association between GC gender and empathy. 5.

While nominally significant, the expression of RPS3A was elevated in CIS compared to adenoma and adenocarcinoma.

P-values more than the Bonferroni-corrected significance threshold, but less than 0.05, were regarded as nominally significant findings.

In the replication data, CNVs of the same type (deletions or duplications) at 20 of the 33 loci were more common among cases ( Supplementary Material, Table S5 ) but only one (16p12.1) was nominally significant (without multiple-testing correction).

Genes surviving multiple testing correction in the gene-mapping analysis and nominally significant genes that were part of significant gene sets were selected for downstream drug-gene annotations.

Effect of FFAR1 polymorphisms on measures of insulin sensitivity There was a nominally significant (unadjusted) association of the G allele of rs2301151 with a ∼73% higher disposition index (DI) and a trend (P = 0.06) towards a ∼52% higher endogenous (1st phase/acute) insulin release (AIRg) when assessed as the recessive model only, accounting for age, gender and BMI ( Table S2 ).

At each cutoff, we calculated k , the number of FUSION hits that replicate in GTEx (GTEx p-value < 0.01), out of the total number of nominally significant GTEx hits, K .

However, given that we selected the gene sets in this study based on interactions with the candidate directional anchor gene, we tested four different p value thresholds ( P T | T = 0.005 , 0.05 , 0.5 , 1 ), which represent a model with all SNPs, nominally significant SNPs, and a threshold an order of magnitude above or below the nominal threshold.

A range of probes at differing levels of significance (not significant, nominally significant, significant after P -value adjustment) were chosen to reflect the range of data provided by the EPIC arrays.

Nominally significant associations with spontaneous lipolysis were detected for two loci in which the WHRadjBMI-increasing allele was associated with an increased rate of lipolysis ( PLXND1 rs10804591 and CMIP rs2925979).

When assessing the causal relationship between subcategories of each level and MG risk, results with the P FDR < 0.1 were considered significant; whereas results with p < 0.05 but P FDR > 0.1 were considered as nominally significant.

As hypothesized the present study observed nominal trend association for SNP rs2726491 with decreased errors in performance IQ, and a nominally significant association with decreased errors in working memory for rs2726491 across both healthy and clinical population samples.

Nominally significant findings from low powered studies are less likely to reflect true effects ( Button et al., 2013 ), and because of publication bias (whereby significant findings are more likely to be published than nonsignificant ones) published low powered studies will also have a high Type I error (false positive) rate.

Results found to be nominally significant were examined in two independent populations.

On the basis of our comprehensive identification of top candidate genes described in this paper, we have chosen the nominally significant single-nucleotide polymorphisms (SNPs) inside those genes in the GWAS data set used for discovery (International Schizophrenia Consortium, ISC), and assembled a genetic risk prediction (GRP) panel out of those SNPs.

In the GOBS cohort, proximate SNPs rs1032704 and rs4931672 at 12p11.21 were nominally significant for the Penn Conditional Exclusion Test (PCET) Face Memory Test and reached the suggestively significant threshold in the GRC GOM cohort for the SVLT LI measure for visual learning (Table 5).

For ER- breast cancer (n = 441 cases) many associations (358) with very rare SNPs were nominally significant using the score test but the p-values failed to stand up to further investigation using exact logistic regression (the exact p-values ranged from 3×10 −5 to 0.21).

We identified seven nominally significant pathways.

A two-sided p<0.05 was considered nominally significant unless otherwise specified.

Using parent-report instruments to assess treatment effects, ketamine was associated with nominally significant improvement in a wide array of domains, including social behavior, attention deficit and hyperactivity, restricted and repetitive behaviors, and sensory sensitivities, a week after administration.

Among the identified metabolites, nominally significant associations were found between androsterone sulfate, cysteine sulfinic acid, and N-palmitoylglycine with stroke, and 3-hydroxy-5-cholestenoic acid with coronary artery disease.

Of the final lipid set, 110 (14.6%) had p < 0.05 indicating a nominally significant difference between cases and controls (Supplemental Table 1 ).