“nominally significant”

anxiety capric acid decanoic acid depression medium‐chain fatty acid mice Japan Agency for Medical Research and Development 10.13039/100009619 JP20dm0107101 3.2 Acute effects of oral low‐dose C10 administration on behavior In Experiment 2 (Figure 2A ), there was a nominally significant main effect of treatment and a nominally significant treatment × time interaction on distance traveled in the open field test (Figure 2E ; Table S2 ).

These differences were nominally significant.

Though UNC showed increased variability in SSEA3+/SSEA4+ populations, leading to nominally significant cross-site differences, all sites had greater than 85% double-positive expression of this marker ( Figure S5 ).

However, we report on two nominally significant SNP s in two genes that have been implicated in the cognitive and social phenotypes of Williams syndrome, BAZ 1B and GTF 2 IRD 1 .

A recent methylome profiling study in major depressive disorder (MDD) did not identify any significant loci after correction for multiple testing; however, they did successfully validated a 60% of the top nominally significant differences [ 11 ].

For multivariable analyses, P values were corrected using the false discovery rate (FDR) via the Benjamini-Hochberg method, with FDR-adjusted P values < 0.01 being considered statistically significant and FDR-adjusted P values < 0.05 as nominally significant. 22 This threshold was chosen to reduce the likelihood of false positives given the large number of comparisons.

The estimate using all the genetic variants is more precise than the estimate using only a subset of variants, even though the additional variants are not associated with calcium at nominally significant levels.

However, two of the identified SNPs were not subjected to multiple testing and were thus considered nominally significant.

When focusing on common genetic variants, we also found nominally significant association of DUSP16 with schizophrenia.

Some of the SNPs represented nominally significant replicas, others had a highly significant p-value ( Table S3 ).

A 2-tailed p < 0.05 for validation tests of FG/FI and association tests with CRC risk was considered nominally significant.

For example, the FTO variant included in the GRS has been shown previously to interact with physical activity on obesity [11] , a finding that was confirmed here, and the SEC16B variant also yielded a nominally significant interaction effect in this study.

It is worth noting that several variables, such as smoking (χ 2 (1) = 7.000, p _raw = .008), showed nominally significant raw p -values but failed to remain significant after correction using either method.

The percentage of nominally significant meta-analyses ranged from 0% for gallbladder cancer (which had only two available meta-analyses) to 74% for head and neck cancer (Table 2 ) and from 0% for legumes/soy products to 54% for alcohol and 67% for grains (which had only three available meta-analyses) (Supplementary Data 4 ).

A number of nominally significant associations were observed for each diet (i.e., 26, 2, and 2 for low-, moderate-, and high-carbohydrate diets, respectively, Supplementary Data 7 ).

Scales with nominally significant 95% CIs for HRs included the FKSI-DRS total score and the EORTC QLQ-C30 emotional functioning, social functioning, dyspnea, insomnia, and financial difficulties scales.

We did not find any clusters with both gene homology and significant promoter similarities, although clusters #8 and #13 both contained homologs and were nominally significant in the promoter similarity score analysis.

P-values<0.05 were considered nominally significant.

Nevertheless, the most significant associations were observed for the set of immunodeficiency genes ( n = 15), and this remained nominally significant even after the exclusion of TLR7 .

Although we did not identify any significant associations between DNA methylation and the obesity measures, several nominally significant results were observed in genes related to adipogenesis, obesity, energy homeostasis and glucose homeostasis ( ARHGAP9 , CDKN2A , FRZB , HOXA5 , JAK3 , MEST , NPY , PEG3 and SMARCB1 ).

All nominally significant variables (p univariate < 0.05), except lung function and medication use variables, were considered candidate independent variables for multivariate regression.

Tumor over-representation of Selenomonas is only nominally significant (Additional file 5 : Table S5).

Less than 25 root and less than 10 leaf metabolites were nominally significant for genotype by treatment interactions (standardized or not; Tables S9 and S10 ), and none passed the FDR threshold.

In addition, a gene-based analysis interrogating for association with schizophrenia based on the meta-analytic p values obtained by the largest schizophrenia genome-wide association study to date ( Ripke et al., 2011 ) (9,394 cases and 12,462 controls) revealed that 8 out of 36 tested autosomal genes of the CYFIP1 interactome had a nominally significant p value (<0.05) for association with schizophrenia ( Tables S4–S6 ).

Resulting p -values ( p ) were adjusted for multiple testing (q) using the Benjamini–Hochberg procedure, and values < 0.05 were considered nominally significant.