“nominally significant”

Across the trials, primary and secondary efficacy endpoints were analyzed in the modified intention-to-treat population and were tested in a combination of sequential, hierarchical and/or simultaneous approaches across comparisons to control type I error; efficacy endpoints that achieved p < 0.05 but either failed or were excluded from the type I error control strategy were deemed nominally significant [ 17 , 18 ].

Conclusion: Both trial's calculated PDQ‐8‐SI showed similar nominally significant improvements vs baseline near/over MCID in LDp/CDp‐treated patients, as previously reported for PDQ‐39‐SI.

Two of the 4 novel lead SNPs from the discovery meta-analysis were nominally significant in at least 1 of the studies with 1 being significant at a Bonferroni threshold of 0.013.

In main effects analyses of SNPs on %MBMI among European Americans (EA), 33 of the established 39 BMI SNPs were directionally consistent with previous results [ 18 ], and 19 of those showed nominally significant association with %MBMI (Additional file 2 : Table S2).

Multivariate and univariate statistics revealed convergent results, as 12 out of the 13 nominally significant metabolites in the univariate approach were also identified as important predictors of PTSD status by the multivariate approach (Additional file 1 : Table S2).

Even if significance levels were modest, PCA discovered nominally significant proteomic and lipidomic biomarkers that differed between the MHO and MUO subgroups.

Of the remaining 45 SNPs, four SNPs (rs4749884 at 10p14, rs12791447 at 11p15.4, rs75718479 at 12q23.1 and rs58262369 at 14q23.2) showed nominally significant associations at P additive <0.05 and had the same directions of association as in the GWAS meta-analysis ( Supplementary Table 5 ).

Only the MTCH2 and FTO loci showed a nominally significant association with birth weight.

At Week 17, SCIT+dupilumab led to nominally significant reductions in sIgE, characterized by median percent change ( Table 4 and Figure 3D ) and median absolute change ( Table 4 ) compared with SCIT.

Two-tailed P-values are presented in this manuscript and P < 0.05 were considered as nominally significant.

To improve our estimate of the population frequency of what are rare events, we examined nominally significant loci in an extended control sample ( n = 6944) including UK controls from WTCCC2 [2533 controls from the UK National Blood Service (NBS) and 2663 from the UK 1958 Birth Cohort (58BC)] ( 28 ).

Genes with a nominally significant correlation were tested for enrichment in human databases (Gene Ontology, KEGG pathways, REACTOME, Complexes (CORUM), Human Phenotypes (HPA), WikiPathway (WP) using gProfiler2 17 .

A study from 2016 surprisingly found a protective role of genetically elevated CRP levels on the risk for schizophrenia, as well as weak (nominally significant) evidence for a risk increasing effect on bipolar disorder as well as a range of other somatic traits (Prins et al. 2016 ).

When examining associations of VPS35 APA with pTDP-43 levels, we noted a nominally significant positive association of VPS35 APA with pTDP-43 in unadjusted analysis ( S4 Fig and S5 Table ) but saw no difference in pTDP-43 levels between the High VPS35 and Low VPS35 APA groups ( S3 Fig ).

Control of Type -1 Error All statistical tests will be conducted at the 0.05 alpha levels, meaning that P ≤ 0.05 will be considered "nominally significant".

Figure 4 displays scatterplots of the observed nominally significant associations of week 4 CBD levels with BDI‐II scores, PHDD, and DPD.

Like in the case–control analysis, the longitudinal results were nominally significant and independent of the immune repertoire diversity measure used (Additional file 8 : Table S6).

We used a raw p <0.05 as the threshold for nominally significant differential expression.

We observed nominally significant association with AD of eight rare variants in six of the 31 chemokine genes in meta-analysis, but none of these variants survived the multiple testing correction (Additional file 2 ).

aeruginosa in children with CF [ 13 ], [ 14 ], and nominally significant associations between age-of-onset of chronic P . aeruginosa infection have been reported recently for other lectin pathway genes: FNC1 , FNC2 and MASP3 [ 15 ].

For GDM, GSA-MiXeR prioritized the “negative regulation of hexokinase activity” gene set from among the nominally significant MAGMA pathways.

Because of the exploratory design and small sample size, no formal adjustment for multiple comparisons was performed; therefore, p values were interpreted descriptively, and borderline nominally significant findings were regarded as hypothesis-generating.

At 5% false discovery rate (FDR), a total of 41 unique CpGs were differently methylated, when comparing any or sustained maternal smoking in pregnancy to non-smoking: 24 were associated with both smoking definitions, 3 with any, and 14 with sustained, although all of them were at least nominally significant in both models (Additional file 1 : Table S3).

Results Sixteen of these SNPs yielded at least nominally significant association to height, representing fifteen different loci including EFEMP1-PNPT1, GPR126, C6orf173, SPAG17 , Histone class 1, HLA class III and GDF5-UQCC .

The strongest subdomain effect emerged in sensory/cognitive awareness ( β = −4.00, p < 0.001), alongside nominally significant benefits across sociability, speech/language, and health/physical/behavior subscales.