“nominally significant”

Of the 23 genes that were identified, only HLA g was found to be at least nominally significant in TCGA-EOCRC and FAP colon organoids, but not TCGA-60+.

A large and nominally significant proportion (45%) of AUD and DPW-associated SNPs were within intronic, UTR and non-coding regions of the genome (Supplementary Fig. 6 ).

At the allelic level, seven of them reached nominally significant association with GDM ( Fig. 2 ).

For interaction terms we considered P <0.1 as nominally significant.

Results for secondary and exploratory outcomes will support or qualify the analyses of the primary outcome, and will be interpreted based on the overall pattern of results with awareness that some nominally significant relationships may be false positive findings in the context of multiple analyses.

For BMI-HDL loci, IV SNPs for BMI from the protective and adverse loci demonstrated opposite directional effects, with nominally significant associations observed for HDL, TG, and stroke, each consistent with the hypothesized protective or adverse effects (Fig. 3 A and B ).

Although, in PiMM subjects there were many more proteins (N=665) nominally significant associated with PD15, in both PiZZ and PiMM the individual proteins had small effect size.

In the more conservative conditional analysis, the ADAMTS7 network remained nominally significant, suggesting that the observed enrichment signal is robust and that genes in this network may confer risk above what one would expect for genes generally expressed in SMC (Supplementary Fig. 17b ).

[18] observed nominally significant association from 6 of 37 SNPs entered into the full-sample association analysis.

Only the Ven-R-CHOP signals (neutropenia, febrile neutropenia, anemia, and thrombocytopenia, together with any grade 3–4 adverse event and treatment discontinuation due to adverse events) and the ibrutinib hematologic signals (febrile neutropenia, anemia, and thrombocytopenia) retained significance after adjustment, whereas the remaining nominally significant findings—particularly those based on small samples or extreme OR values—are interpreted as exploratory and hypothesis-generating.

Utilizing LDL levels as a stand-in, it demonstrated that HMG-CoA reductase had a substantial impact on upstream IL-6 and nominally significant impacts on Apolipoprotein B and IL-6RA.

40 , 41 Interestingly, our study did not observe nominally significant associations between VAT and PCOS risk.

Additionally, the lead variant associated with FEV1 max, chr5_43372087_A_G/rs11950040, is also common in European-ancestry cohorts from the 1000 Genomes and has a nominally significant association with peak expiratory flow in a multi-ancestry European cohort. 38 Although we combined the cohort across sites due to low sample sizes, the slight genetic differentiation and varying environmental or selective pressures across the sites suggest that deeper sampling and investigations in each region could identify group-specific genetic associations with traits of interest.

Family history of dementia also had a nominally significant effect in both cohorts in which it was measured (HR 1.16–1.27).

These same SNPs were nominally significant in the analyses using the entire dataset.

In the candidate approach, miR-499a showed a nominally significant association with lithium response, providing some evidence for involvement in both development and treatment of BD.

Regarding fatigue related PRO metrics, after Benjamini-Hochberg correction, ZKONE’s sleep efficiency feature shows a nominally significant association ( r = − 0.21 ) with self-reported mental fatigue in the healthy group only.

[ 28 ] The P value for the Bonferroni correction was set at 0.0071 (0.05/7 endpoints), while P < .05 was considered nominally significant.

The second mutation ( CSPG4 V901G ), also located in a LamG domain, segregated with schizophrenia in two independent pedigrees and exhibited nominally significant enrichment in the Swedish Schizophrenia Exome Sequencing Study [ 8 ].

Moreover, the MdLF showed nominally significant correlations with errors of omission in the GDS vigilance task.

Among the 77 shared loci, LAVA identified 56 genetic loci showing nominally significant local heritability in both depression and volumetric phenotypes.

Interestingly, a recent study of 1,578 Germans reported nominally significant association of the diabetes-related C allele of rs4607103 with an increase in OGTT-derived surrogate measures of insulin resistance [9] .

Three of the SNPs (rs1268055, rs7785891 and rs2782448) were nominally significant, though none remained significant after Bonferroni correction.

p - values less than 0.05 were considered nominally significant.

Furthermore, it was nominally significant only for fathers when TDT was performed separately for fathers and mothers.