“nominally significant”

In other sensitivity analyses, we observed the effect of metabolites on cognitive function (3MSE) to be modified by age, but in stratification analyses, the significant associations were no longer nominally significant, although the attenuation appeared attributable to the smaller sample size within each age group ( Supplementary Table 8 ).

When comparing DNA methylation patterns between children in the intervention and control groups, a number of nominally significant differences were observed even after adjusting for potentially important confounding factors, such as age, maternal smoking, and PTSD status, batch effects and cell counts, as well as baseline methylation levels.

In each iteration, p-values of nominally significant probes were recorded and compared to p-values of the same probes obtained from continuous analysis by CAG length of all samples using the Pearson’s correlation test.

We observed significant enrichment of MBSVs in schizophrenia, depression, bipolar disorder, and anorexia nervosa, particularly in genes targeted by several miRNA families, including miR‐335‐5p, miR‐21‐5p/590‐5p, miR‐361‐5p, and miR‐557, and a nominally significant association between miR‐323b‐3p MBSVs and schizophrenia risk.

Results Nominally significant differences in DNA methylation were observed in all comparisons, with differences withstanding correction for multiple testing when the ALH or LH group was compared to the MIs.

As illustrated in Figure 1 , 13 of the 18 genes that demonstrated a significant change in expression and 6 of the 9 genes that had a nominally significant change exhibited an immediate down-regulation post-axotomy.

Additionally, 12 of these metabolites showed a nominally significant change in post-PEA surgery in the paired sample validation analysis (correcting 15–100% of perturbation versus healthy controls), with seven meeting multiple test corrections including N2,N2-dimethylguanosine and sphingomyelin-(d18:1/22:1, d18:2/22:0, d16:1/24:1) ( supplementary table S5 and figure 4b ).

To do so, we refit the above MIMIC model, including only those white and grey matter regions that were nominally significant in the modality-specific analyses.

The other genes, such as STAT4, IL-12A, IL-12RB, BACH2 and CTLA-4/CD28, were described as nominally significant ( 2 ).

Consistent with previous work, several nominally significant pathways in AUD ASTs regulate calcium signaling (Supplementary Data 12 , 13 ).

The significant interaction between rs17239735 and ɛ2 is explained in part by a nominally significant association of this SNP in ɛ3/ɛ3 subjects in the opposite direction (Table S3 ).

While the authors report nominally significant findings in specific subgroups, formal statistical interaction testing and appropriate correction for multiple comparisons would strengthen the robustness of these conclusions. 3.

Thus, the collective weight of nominally significant MR, robust colocalization, and significant SMR findings strengthens the causal hypothesis for MASP1, despite statistical imprecision in the MR estimate alone.

Because of the nominally significant casual effects of three various neuroticism clusters on the same psychiatric disorder PTSD, we utilized multivariable mendelian randomization (MVMR) to regulate the pleiotropy arising from the overlap among the neuroticism clusters (Burgess & Thompson, 2015 ).

Using the MR IVW fixed effects model, cg00036588 was causally associated with type 2 diabetes at a nominally significant p value of 0.039 (OR=0.76) (Fig. 3 a and ESM Table 5 ).

[ 4 ] found that two established risk loci for IAs and TAAs had nominally significant effects; however, there was no evidence for polygenic overlap.

While gene-level collapsing analyses did not reveal novel associations, we observed that nominally significant genes from several collapsing models were significantly enriched for genes predicted to be associated with pulmonary fibrosis.

In the human study there were no significant effects of PMI on PAK1 level (F 1,31.9 = 0.76, p = 0.39), although we did detect the previously mentioned nominally significant interaction between PMI and diagnosis.

Conclusion Dupilumab treatment versus placebo resulted in nominally significant improvements in signs, symptoms, and quality of life in patients with PN without optimal response by week 24, supporting the benefits of continued treatment.

Regarding the polygenic burden analyses, we found a nominally significant association between the PGS for ease of getting up and Li treatment response.

For each tissue and set of nominally significant DMCs, we tested for enrichment of GO terms and KEGG pathways, separately.

As a second step, all nominally significant alleles from the same HLA -gene were analysed in a multivariate regression model.

Table S7: Summary statistics of the nominally significant HLA allele in the ciprofloxacin‐restricted analysis, along with other relevant alleles mentioned in the FQ‐DILI analysis.

The overall P ‐value (omnibus p ‐value) was reported based on collective conditional analysis, and a threshold of P < 0.05 was considered nominally significant.

TWSG1, a protein risk factor also found to be an independent risk factor for CKD progression 20 , with a nominally significant MR association in CKDi25 in our study, is an antagonist of BMP 7, which is produced in the kidney and is protective against renal fibrosis and other types of renal injury in experimental models 21 .