“nominally significant”

Kaplan–Meier survival analysis followed by a log-rank test demonstrated that individuals in the high-risk PRS BMI group a had nominally significant higher likelihood of developing dyslipidemia and hypo-HDL cholesterolemia.

Widely targeted metabolites robustly associated (nominally significant) with traits using all three MR methods (IVW, MR-RAPS, and GSMR, same direction) and two MR methods (IVW and MR-RAPS, same direction) were defined as tier 1 and tier 2, respectively.

Further analyses outside of established GWAS risk loci identified 18 SNPs with allele-specific TFAP2A binding, but again, none of them showed a nominally significant association with nsCL/P.

The influence of concurrent treatment in H1975 cells, however, was quite unremarkable across all treatment regimens; and only nominally significant inhibitions were observed with sequential treatment schedules of 1 h with EGFR-TKI concentrations of 0.01, 0.1 and 10 μM.

Associations with a p ≤.05 were considered nominally significant.

In addition, this study involved multiple statistical comparisons, which increases the possibility of type I error and necessitates cautious interpretation of nominally significant findings.

None of the nominally significant associations were consistently replicated between cohorts.

However, when performing analyses using the IPA variable, no association was found between this variant and on‐ticagrelor IPA regardless of agonist or concentration used, suggesting that nominally significant associations observed in analyses of maximal platelet aggregation data were caused by differences in baseline platelet aggregation and not due to a pharmacogenetic relationship between CES1 and ticagrelor.

Analyzing the association between the rs12970134 and BMI, we found a nominally significant association.

Performing this analysis within ancestries showed that all genome-wide significant loci, except POR, had nominally significant effects in at least one non-European biogeographical group ( appendix 2 sheet 5 ).

In the discovery set, we found 27 circulating proteins with a nominally significant association.

Main Effects of Variation in CLOCK on Current Depressive Symptoms and Lifetime Depression Linear and logistic regression models on BSI-Dep (for current depression) and DEP (for lifetime depression), respectively, identified a few SNPs with a nominally significant main effect, but significant clumps could not be formed, furthermore, all p -values exceeded the maximum threshold for top SNP ( p = 0.001) [ Supplementary Tables 1 , 2 for lifetime depression (DEP) and current depressive symptoms (BSI-Dep, respectively), but significant clumps for main genetic effects could not be identified].

A 2‐tailed P <0.05 was considered nominally significant.

in BMI (kg /m 2 ) and MM risk, with the UK-GWAS series being nominally significant ( Figure 1a ).

In genome-wide scans of AFC, we also identified one marginally genome-wide and several nominally significant SNPs within several other genes associated with follicle number in both ethnic groups.

Additionally, consistent with results in PRIME, but in contrast to PRIME2, the pooled analysis showed nominally significant improvements in sleep quality from week 4 to week 24. 12 Analyses by baseline demographic subgroups showed a consistent trend of dupilumab benefit compared with placebo in achieving ≥4-point reduction in WI-NRS, IGA PN-S 0 or 1, or both, at week 24, with comparable effect size in all demographic subgroups that included sufficient patients for meaningful testing.

Here, we used a p -value of <0.05 as a cutoff, which clinical trials have suggested as an appropriate cutoff for pilot studies ( Lee et al., 2014 ) and focused on the pathway enrichment, which inputs nominally significant results.

Consequently, Type I error inflation is possible, and nominally significant findings, particularly at later time points, should be interpreted cautiously.

For and the variance grows by a factor of 50, turning nominally significant findings into noise.

Results Our findings revealed several significant and nominally significant associations between genetic polymorphisms and primary emotions which showed a clear sex-specific pattern.

Gene Ontology analysis We sought to determine whether our nominally significant differentially methylated regions were in or near genes that clustered together functionally.

In the final model, four of these remained [X—17676, palmitoylcarnitine (C16), margaroylcarnitine (C17)* and imidazole propionate; see Table 1 ], and 80 metabolites were nominally significant.

Results Screening this linkage region, we found an over representation of nominally significant associations in five genes (MLL3, DPP6, PAXIP1, HTR5A, INSIG1) .

Correlations surviving FDR correction at q < 0.05 are indicated separately, whereas nominally significant correlations that did not survive correction should be interpreted as hypothesis-generating rather than confirmatory.

The Development and Interaction networks encompassed broad functional categories, spreading the networks’ genes among many different categories, so that enrichment results rarely survive multiple testing correction; nominally significant functional enrichment terms are therefore included for the annotation of the Development and Interaction networks (Fig. 2 , top panel ).