“nominally significant”

In the separate risk analysis for POAG ( Table 2 ) and OHT ( Table 3 ), we found a nominally significant association only between the MMP3 polymorphism rs3025058 and the risk for OHT.

4 A, Table 1 ), and unlike disease versus RHI DE genes, there is no apparent relationship between the direction of effect of these genes between CTE-L+RHI and CTE-H, and only 3 genes were nominally significant in both analyses (Figure 4 A).

Composite region volumetric MRI revealed a trend towards tissue preservation in participants treated with either dose of CT1812, and nominally significant differences with both doses of CT1812 compared to placebo were found in the pericentral, prefrontal, and hippocampal cortices.

Among these nominally significant pathways include the cell cycle, synaptic vesicle trafficking, mRNA splicing, Alzheimer's disease-presenilin pathway, coenzyme A biosynthesis, ubiquitin-proteasome pathway, transcriptional regulation by RUNX1, programmed cell death/apoptosis, class B/2 (secretin family receptors), TCF-dependent signaling in response to WNT, C-type lectin receptors (CLRs), DC42 GTPase cycle, and RAC1 GTPase cycle ( Figure 4 and Table S6 ).

Roughly, the failure to replicate a nominally significant association between an index SNP and type 2 diabetes in a tested population does not necessarily indicate the absence of an association at the relevant locus.

The Ser37Ala missense variant is nominally significant for osteoporotic fractures, with an estimated RR of 4.2, and hapB is nominally significant for low BMD, with an estimated RR of 2.1.

Of the primary hypotheses, the following nominally significant associations were also observed: MDD PRS with apathy, ADHD PRS with violent/aggressive behavior, PD PRS with cognitive impairment, and (interestingly, given the relatively small training GWAS) OCD PRS with perseverative/obsessive behavior.

Quantification of various cell types revealed a nominally significant higher abundance of cycling radial glial (RG-div) and cycling intermediate progenitor cells (IPC-div) alongside a lower abundance of differentiated ENs in patient organoids compared to control organoids (Fig. 2c–e ).

Nominally significant heterogeneity was observed for index variants of loci 5, 8 and 11.

Some combinations yield a nominally significant correlation while others do not.

In the subgroup analysis, there was a nominally significant interaction in patients < 70 years (HR, 1.03; 95% CI, 0.40–2.64) or ≥ 70 years (HR, 1.66; 95% CI, 1.05–2.61; P for interaction = 0.03).

Moreover, when considering all nominally significant findings from the GREA (Online Resource 1, Supplementary Table 8), 31 out of 80 unique gene sets were related to immune function.

KEGG pathway analysis of the nominally significant S2-SPep phospho-targets showed engagement in ERBB, MAPK and neurotrophin signaling among the most enriched pathways ( Figure 6 B).

The results were nominally significant but did not survive the rigorous Benjamini-Hochberg correction for multiple testing.

If an ROI showed at least a nominally significant association with total BIS-11, we performed follow-up multiple regression analyses (with correction for multiple comparisons) to test for relationships between FE-PE2I BP ND and each of the BIS-11 3-factor 10 subscales (Attentional, Motor, and Nonplanning impulsivity), in order to see if a specific aspect of impulsivity was associated with regional DAT.

FDR p < 0.05 was considered as statistically significant and unadjusted p values < 0.05 as nominally significant.

Significant associations were observed for the ARNTL and PER1 genes, while nominally significant associations were found for the NPAS2 , CLOCK , RORB and NR1D1 genes.

Then, obtained DE genes were further filtered to include only hits that are already nominally significant in GSE144136 or GSE213982 and then were meta-analysed using random-effects model in metafor similar to primary pipeline described in Section 2.8.

The differential effect was largely driven by the findings from the Beta-Blocker Evaluation of Survival (BEST) trial, which reported a nominally significant interaction indicating increased mortality among Black participants.

To explore the functional relevance of regions associated with clinical outcome, FUMA [ 49 ] will be used to determine if the risk SNPs and their proxies ( r 2 ≥0.6, within 1Mb and nominally significant) are located within putative functional elements such as active histone marks or transcription factor binding motifs.

Two SNPs, in NTRK2 and SCN8A achieve nominally significant p-values (<0.05) in Munich cohorts, but with opposite direction of association to RADIANT.

A non-synonymous coding single nucleotide polymorphism (SNP) rs2522833 in the PCLO gene became only nominally significant after post-hoc analysis with an Australian cohort which used similar ascertainment.

Fourth, our correlations in NCVs to microbiome were only to family taxa and were only nominally significant due to limited sample size; therefore, larger studies with more granular genus- or species-level information are needed to draw deeper insight.

In this context, even when our PGS analyses resulted in only nominally significant findings, these suggested that common genetic factors link Li response and other conditions, particularly insomnia, in BP, and pinpointed potential contributing genes.

For the genetic variants showing a nominally significant interaction, we assessed the relationship in an additional 621 children in Project Viva, which is an independent longitudinal cohort study, and used meta-analysis to combine the results for the two studies.