“nominally significant”

MR results with p -values lower than the adjusted significance level were considered statistically significant, while MR estimates with p -values less than 0.05 were considered nominally significant ( 31 ).

A nominally significant association was found for SHBG with lower risk of large serrated polyps (≥ 10 mm) (OR, 0.47, 95% CI 0.17–1.35, P for trend = 0.02) as well as free estradiol and free testosterone with higher risk of conventional adenomas (OR, 1.54, 95% CI 1.02–2.31, P for trend = 0.03 and OR, 1.33, 95% CI 0.99–1.78, P for trend = 0.03, respectively).

Treatment-Dependent Changes in Lipid Classes Thirteen of the 28 lipid classes had nominally significant supplementation-related changes after the 30-days ( Supplementary Table S2 ).

Excluding the previously published datasets, 56 of the 118 available variants were at least nominally significant in a meta-analysis of HUNT and MGI alone (Supplementary Data 6 ).

More specifically, we filtered out variants whose association with MS susceptibility was not significant among any of these cohorts, whereas we only retained variants that were at least nominally significant or absent in any of the aforementioned large MS datasets.

A nominally significant correlation was found for this same measure and expressive language at follow-up.

For three of the 16 pseudogenes the correlation between expression level and the intron expression statistic was nominally significant (α = 0.05).

A p value of < 0.05 was considered nominally significant.

21 Within this regional group, we discern genetically distinct communities, such that individuals from these sites (except for Tepecik-Çiftlik) tended to share more recent common ancestry with individuals from the same settlement compared with those of other settlements (among 576–11,780 D -tests per site, 84%–93% were nominally significant in this direction; Figures S3 D–S3F and Table Z7).

We also identified nominally significant interactions between MedDiet and the APOE4 genotype in relation to 1,7-dimethyluric acid, a derivative of caffeine metabolism with established antioxidant properties and potential neuroprotective effects 41 ( Supplementary Text ).

Those receiving semaglutide not only lost around 10% of their body weight but also felt better and had nominally significant reductions in heart failure outcomes and total mortality, when compared to placebo-treated participants.

This group approached the gene as a biological and statistical candidate, citing its relationship with the recessive early onset dementia and bone cyst disease, Nasu-Hakola; the identification of homozygous TREM2 mutations in three Turkish patients with a frontotemporal dementia like syndrome; and evidence of a nominally significant linkage association between a region on chromosome 6 containing the gene and risk of AD.

Table 1 summarizes the 24 phenotype-SNP associations that were genome-wide significant in the discovery sample and nominally significant in the replication sample.

We set a threshold for a single-allele P value of <0.05 as nominally significant for use within the PARIS analysis and used a permutation test of 10,000 permutations to determine the significance of the pathway analyses.

On the other hand, some nominally significant candidate gene associations might suffer from lack of proper statistical correction for multiple testing (e.g., Bonferroni correction).

A 2-sided P value of less than 0.05 was considered nominally significant.

Functional enrichment analysis was performed on all nominally significant metabolites using Wilcoxon sum of ranks test and was followed by p -value adjustment using FDR method.

An earlier study also identified OBCAM to be implicated in schizophrenia; however, the association was nominally significant ( O’Donovan et al., 2008 ).

Among our non-coding candidate regions, there is significant enrichment in lung, nominally significant enrichment for adipose and adrenal tissues, and none for prostate or kidney (Fig. 3 ).

Owing to its role in obesity-predisposing genetic variants, FTO has been shown to have nominally significant associations with cardiovascular disease and is referred to as a cardiovascular biomarker ( He et al., 2010 ).

Genetic association analyses with RA status Three SNPs (rs911263, rs2525504, rs17756404) were identified to be nominally significant in the discovery stage.

For autism, 56 metabolites were nominally significant (aOR range 0.01–9.96), with citrate, cortisone, and imidazole lactate being the top positively associated metabolites with the highest ORs.

The LR did not confirm this rule after applying Bonferroni correction (the p -values were nominally significant for all groups except the old).

The causal effect of an exposure on MS is considered indicative if the effect estimate is nominally significant in the IVW method and no contradictory results are found in the sensitivity analyses.

An additional ten genes showed nominally significant differences in expression ( Table 9 ).