“nominally significant”

Pairs with nominally significant overlap that did not meet significance criteria after Bonferroni correction for multiple hypothesis correction were considered ambiguous and removed from the datasets.

However, before correction for multiple comparisons, several HLA alleles (i.e., DRB1*16:01, DRB1*04:04, DRB1*01:03 ) were nominally significant.

In SUSTAIN 6, nominally significant heterogeneity of semaglutide efficacy by baseline BMI was observed for CV death/myocardial infarction/stroke (major adverse CV events, primary outcome of both; P interaction = .02); otherwise, there was no statistical heterogeneity for either GLP‐1 RA versus placebo across BMI categories for key CV and kidney outcomes.

First, we have previously shown that it is possible to identify real copy number changes at VNTR loci using short oligonucleotide arrays [35] ; second, copy number changes at this locus were identified by multiple platforms in the current study; third, the association is nominally significant in both the Utah and Porto cohorts; fourth the locus is within the AZFb/c region.

After exclusion of this outlier, the difference between homozygous major allele carriers and risk allele carriers remains nominally significant (CC 2.6 ± 0.3 vs.

2 , panel C) demonstrate a nominally significant association with CSF ptau levels.

In addition to ABO , we observed nominally significant ancestry heterogeneity for three loci: LOC100505841 , CDKN2B-AS1 , and COL4A1 .

A 2-sided P < .05 was considered nominally significant with no adjustment for multiple testing.

We also found nominally significant relations of several other SNPs with metacognitions and problematic drinking.

In Table 4 , the only nominally significant unadjusted between-group change-score difference was observed for FMA-UE motor gain, which was larger in the RAT group than in the COT group (mean difference, 6.79 points; 95% CI, 0.42 to 13.16; p = 0.037).

The results remained nominally significant when using Age-corrected sulcal pattern similarity values for the association between SP-Combined and PANSS-GP (r = −0.16; p nom = 0.04), but not with PANSS total (p nom > 0.05).

Results Nominally significant associations were observed between SLC6A4 genetic variants (5 -HTTLPR , rs140700, rs4251417, rs6354, rs25528, rs25531) and DNA methylation at several CpG sites.

studied the single nucleotide polymorphisms (SNPs) of hormonal genes – androgen, estrogen, and prolactin and corticotropin-releasing hormone and found nominally significant main effects on pedophilic sexual interest for these SNPs linked to these hormones.

Another study found a small nominally significant reduction in mortality risk in teaching hospitals for colorectal cancer surgery (RR 0.96; 95% CI, 0.93–0.99).

2023a ) reported improvement in HAMD-17 scores and insomnia symptom score showed nominally significant differences in the zuranolone 20 mg groups when compared with the placebo group at Day 15.

We observed two other nominally significant associations with the binary FECD trait, one SNP each in pituitary homeobox 2 ( PITX2 ) (rs17554590) and autogenous vein graft remodeling associated protein 8 ( AVGR8 ) (rs1034200), with p values of 0.028 and 0.015, respectively, for FECD status adjusted for CCT ( Table 3 and Table S1 ).

For aim 1 the significance threshold was set at p ≤ 0.005; all results greater than 0.005 and less than 0.05 were considered nominally significant.

These variants included; Ecotropic Viral Integration Site 5 ( EVI5 ) rs11808092 (OR: 2.04, 95%CI: 1.4–2.9), TNF Receptor Superfamily Member 1 A ( TNFRSF1A ) rs1800693 (OR: 2.01, 95%CI: 1.45–2.75), Lymphocyte Function-Associated Antigen 3 ( CD58 ) rs1414273 (OR: 2.2, 95%CI: 1.5–3.2), and a nominally significant and not clearly robust Methylenetetrahydrofolate Reductase ( MTHFR ) variant rs1801131 (OR: 1.4, 95%CI: 1.02–1.9).

In the WHI trial, postmenopausal women who randomly assigned to combination of estrogen plus progestin therapy group were at reduced risk for CRC compared to those assigned to placebo group, the reduction (37%) was nominally significant [ 12 ].

Nominally significant variants are presented in Supplementary Table 4 .

Conditional analysis of the top OPRM1 variants (rs1799971 and rs79704991; r 2 = 0.02) demonstrated that these variants are not independent as indicated by each variant falling below GWS when conditioned on the other; however, the variant effects remained nominally significant and there were no significant differences in the conditioned vs. unconditioned effect sizes.

Two-sided P < .05 was nominally significant, P < .025 = 0.05/(1 exposure × 2 outcomes) was Bonferroni significant for main MR analysis.

P values ≤0.05 are cited as nominally significant.

Of the 885 DCEGs, 758 genes were included in gene based association analyses of the GWAS datasets, and 105 genes showed nominally significant association with SCZ and 82 showed nominally significant association with BPD.

The treatment difference observed at Month 1 ( P < 0.001) was nominally significant because of the multiplicity step‐down procedure employed. 3.4 MSHQ bother domain Baseline MSHQ bother scores were similar between treatment groups, with the mean (SD) scores of 16.7 (3.36) and 17.1 (3.18) in the DUT‐TAM FDC therapy group and in the placebo group, respectively.