Male patients with schizophrenia had larger right Hb than healthy male participants but this analysis was only nominally significant at p = 0.01, uncorrected for multiple comparisons.
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After accounting for the lowest measured BMI, the association between PRS AN and AN diagnosis remained nominally significant ( p = 0.01, OR = 1.03, SE = 0.01) indicating the PRS AN contributes to the AN diagnosis beyond contributions to body weight.
Nominally significant associations ( p < 0.01) were detected for several variants in genes encoding vasoactive intestinal peptide receptor 2 ( VIPR2 ), period circadian regulator 2 ( PER2 ), casein kinase 1 epsilon ( CSNK1E ), and activator of transcription and developmental regulator ( AUTS2 ), but no signal survived correction for multiple testing.
The only nominally significant interaction between MASLD and metabolite factors on HFpEF associations was for Factor 31, composed of the metabolites ketoglutarate and phenyl sulfate (p-value = 0.01).
The correction was done in two steps: first, we regressed the expression vector of each gene against covariates and selected those with nominally significant coefficients ( p < 0.01).
Nominally significant results ( P < 0.01) are cited.
However, two SNPs showed a nominally significant association with the risk of being a ‘weight gainer’ ( PYY SNP rs1859223, OR = 0.91 per minor allele, P = 0.01; CCK SNP rs11571842, OR = 1.06 per minor allele, P = 0.03) ( Table S3 ).
If no strain is found to be nominally significant under both tests (p-value ≤ 0.01 by default), iteration is halted and the previous mixture model is returned.
We conducted a MR analysis and found that there was a nominally significant association of GDF15 with an increased risk of Alzheimer's disease (IVW: OR: 1.12; 95% CI: 1.027–1.220; P = .01).
For K trans , we defined a 256 gene signature associated with 14-week treatment response by identifying genes with a nominally significant gene expression by treatment interaction term (p<0.01).
Pseudo-bulked expression from 11q23.1 nominally significant trans-eQTL targets, present in the scRNAseq dataset (p < 0.01, n = 273), Fig. 2 a, was then subject to WGCNA 20 .
No genes remained significant after multiple testing correction; however, nominally significant candidates ( p < 0.01) highlighted pathways related to steroidogenesis and metabolic regulation.
For DPB1*1501, the only nominally significant association ( p = 0.01) was within ASD cases.
When specifically assessing the association between the maximum increase in inflammatory markers and the maximum increase in ratios after LPS stimulation, only the maximum increase in ratio kynurenine/tryptophan and the maximum increase in CRP showed a nominally significant correlation (r = 0.76, p = 0.01) (Fig. 4 B).
Phenotypic similarity analysis for locations within the NaV1.2 channel and recurrent variants Phenotypic similarity was nominally significant between individuals with missense variants regardless of location ( p = 0.01, n = 341) and also among individuals with missense variants localized to either the S1 segment ( p = 0.009, n = 18) or domain DIV ( p = 0.05, n = 65).
Two of the investigated polymorphisms, rs2072493 in TLR5 and rs3853839 in TLR7 , showed nominally significant allelic association with RA (p≤0.01; Table 1 ).
In addition, the direction of effect was consistent for five of the six EA index SNPs and the magnitude of effect was larger than in EA and nominally significant (p = 0.01) for the index SNP at SLC5A10 in this smaller AA study sample.
Replication of Top Signals Of the 63 total metabolites identified in Step 1 (significant plus nominally significant), 46 (8 metabolites with FDR < 0.05 + 39 metabolites with p < 0.01) had available data in the PEAR replication cohort ( Table S6 ).
In addition, for FI, the analyses showed multiple significant enrichment peaks in blood in men, whereas those in women were only nominally significant ( P = 0.01) (Supplementary Fig. 3a ).
Interestingly, a recent analysis of WES data from the UK Biobank ( 43 ) identified a nominally significant gene-based association ( P = 0.01, sequence kernel association test [SKAT]) for THBS1 rare coding variants and POAG (ICD-10 diagnosis code H40), suggesting that further study of rare THBS1 -coding variants in adult-onset POAG might be of interest.
Results were considered significant for p -corrected < 0.05 and nominally significant for p < 0.01 and p -corrected > 0.05. 3 Results Sample characteristics are presented in Table 1 .
Nominally significant differences in ON versus OFF state were found for only one protein (paired permutation test nominal p < 0.01).
The novel SNPs on 11p15.5 were nominally significant ( P < 0.01), whereas SNPs near FAM13A were not significant ( P > 0.1) (Additional file 1 : Table S6).
A total of 7284 genes with nominally significant ( p < 0.01) heritability were included in the association analysis for each MD phenotype.
Nominally significant genes were identified by p < 0.01 and absolute log 2 fold change > 0.5.