“nominally significant”

The signal we identified on COL4A2 for females (rs1927355), was similarly replicated in Geisinger MyCode, in which it was genome-wide significant in the female-specific GWAS (Beta G ± SE = 0.08 ± 0.01, P = 9.25 × 10 −10 ), and nominally significant in the male-specific GWAS (Beta G ± SE = 0.05 ± 0.02, P = 0.01).

An analysis of a haplotype incorporating these SNPs showed a nominally significant interaction term (p = .01).

We assessed our 5 week dataset in comparison with the previously published 4 week old cohort, and found a portion of the nominally significant genes (nominal p-value < 0.01) that overlapped with the previously published microarray ( Figure 3—figure supplement 3A ).

A total of 7284 genes with nominally significant ( p < 0.01) heritability were included in the association analysis for each MD phenotype.

As an exploratory analysis, the combined analysis was applied on the SNPs that were nominally significant (p < 0.01) in both the discovery and validation analysis.

In line with power expectations ( Supplementary Figure 5 ), 75 of these regions were genome-wide significant in at least one of the two cohorts and always at least nominally significant (p<0.01) in the other.

In the present longitudinal CHAT analysis, we observed nominally significant ( p < 0.01) age-related change, but only for a modest flattening of REM slopes (Extended Data Fig. 10-1 ).

There was a nominally significant ( P = 0.01) association between TPO positivity and the PTPN22 R620W variant (rs2476601).

Causal Effect of Sleep Characteristics on Alopecia In the forward MR analysis ( Table 1 ), the IVW method indicated that the genetically predicted insomnia had a nominally significant causal effect on alopecia areata (OR (95% CI) = 3.88 (1.5–10.04), P = 0.01), indicating that insomnia is linked to a higher risk of alopecia areata.

However, two SNPs showed a nominally significant association with the risk of being a ‘weight gainer’ ( PYY SNP rs1859223, OR = 0.91 per minor allele, P = 0.01; CCK SNP rs11571842, OR = 1.06 per minor allele, P = 0.03) ( Table S3 ).

Additional proteins of interest that were nominally significant include glutathione-S transferase P ( Figure 4i group effect; P <0.01), tyrosine protein phosphatase non-receptor 11 (SHP2, Figure 4j , group effect; P <0.01) higher in ODS and brain derived neurotrophic factor (BDNF; Figure 4k group × time effect, P <0.05) and Peptide YY (PYY Figure 4l , group × time, P <0.01).

For DPB1*1501, the only nominally significant association ( p = 0.01) was within ASD cases.

However, there was a nominally significant association with later age at last birth when data were controlled for age and BMI ( P = 0.01).

Variants for which this binomial test was nominally significant (P < 0.01) were deemed to be candidate mosaic variants.

The nominally significant association signal at this lead variant (rs11934731, effect size for the minor allele = 0.029 SD, P -value = 0.01, MAF = 33%) was slightly attenuated when we performed conditional analysis with MEPE p.Lys70IlefsTer26 as a covariate in the model (effect size conditional = 0.021 SD, P -value conditional = 0.06; Supplementary Fig. 1 , Supplementary Data 1 ).

The only nominally significant interaction between MASLD and metabolite factors on HFpEF associations was for Factor 31, composed of the metabolites ketoglutarate and phenyl sulfate (p-value = 0.01).

Most SNVs also show association with hypertension in the UK Biobank data, for example 93 of the 107 validated sentinel SNVs are nominally significant ( P < 0.01) ( Supplementary Table 7 ).

26 Nominally significant genes from the burden test (defined as p<0.01 to minimise noise) were included in the test.

However, we observed nominally significant interactions (all P < 0.01) between carbohydrate intake and MTNR1B- rs1387153 for FG with a 0.003 mmol/L higher FG with each additional 1% carbohydrate intake in the presence of the T allele, between sleep duration and CRY2 -rs11605924 for HDL-cholesterol with a 0.010 mmol/L higher HDL-cholesterol with each additional hour of sleep in the presence of the A allele, and between long sleep duration (≥9 h) and MTNR1B -rs1387153 for BMI with a 0.60 kg/m 2 higher BMI with long sleep duration in the presence of the T allele relative to normal sleep duration (≥7 to <9 h).

Pseudo-bulked expression from 11q23.1 nominally significant trans-eQTL targets, present in the scRNAseq dataset (p < 0.01, n = 273), Fig. 2 a, was then subject to WGCNA 20 .

In the first, we tested if all nominally significant CpGs ( p value < 0.01) in the three peripheral tissue MWAS (SEED, SSC, and MINERvA) have a shift toward lower p values in the SCDC MWAS (one-sided Wilcoxon rank-sum test).

However, we still identified nominally significant rank correlations between estimated relative astrocyte proportions and IHC quantifications for GFAP in the parietal cortex (ρ = 0.27, p = 0.01) as well as estimated relative microglia proportions and IHC quantifications for IBA1 in the hippocampus (ρ = 0.38, p = 0.0003).

Two of the investigated polymorphisms, rs2072493 in TLR5 and rs3853839 in TLR7 , showed nominally significant allelic association with RA (p≤0.01; Table 1 ).

When specifically assessing the association between the maximum increase in inflammatory markers and the maximum increase in ratios after LPS stimulation, only the maximum increase in ratio kynurenine/tryptophan and the maximum increase in CRP showed a nominally significant correlation (r = 0.76, p = 0.01) (Fig. 4 B).

Authors used PGC2 schizophrenia GWAS summary statistics [ 35 ] to calculate gene-level p -values, then they mapped nominally significant genes ( p -value < 0.01) to a human protein–protein interaction (PPI) network constructed based on the iRefindex database [ 120 ].