“nominally significant”

We also identified several cancer pairs for which the genetic correlations were nominally significant.

The other nominally significant interactions included CD2AP (rs9296559) x PICALM (rs3851179), CLU (rs11136000) x PICALM (rs3851179), and CLU (rs11136000) x MS4A6A (rs610932).

Finally, in humans, OX2R polymorphisms affect morningness–eveningness, napping, and reports of excessive daytime sleepiness, while OX1R polymorphisms have smaller but nominally significant effects on sleepiness and napping, based on numerous studies and data in the Sleep Disorder Knowledge Portal ( https://sleep.hugeamp.org/ ) ( 40 – 43 ).

A nominally significant difference in OS in favor of patients randomized to eribulin compared with control in patients with bone, lymph node, and chest wall/breast/skin metastases at baseline was observed.

Among the 7 metabolites identified in the primary analysis, most remained nominally significant after additional covariate adjustment and in restricted analyses, with complete directional concordance (Supplementary Data 1 ).

18 However, this inconsistency was nominally significant, and a complementary analysis confirmed benefits of semaglutide versus placebo across a continuum of BMI values. 18 As the current pooled post hoc analysis included data for OW s.c. and OD oral semaglutide from the SUSTAIN 6 and PIONEER 6 CVOTs, respectively, our findings on consistent risk reduction of CV outcomes regardless of baseline BMI support previous conclusions.

Pairwise comparisons using Fisher’s exact test show P = 0.042 (nominally significant) between full-length MYO7A and MYO7A-RK/AA on the formation of protein blobs at stereocilia tips (Supplementary Fig. 3a ).

EXSCEL reported a nominally significant reduction in all-cause mortality (HR: 0.86, 95% CI: 0.77-0.97) despite a neutral primary efficacy result [ 17 ], and PIONEER 6 showed lower cardiovascular and all-cause mortality (all-cause death, HR: 0.51, 95% CI: 0.31-0.84), albeit on a small number of events [ 19 ].

Although each of these associations was nominally significant, neither reached the prespecified Bonferroni-adjusted P value.

Case-control association analyses using clinically discordant DZ twins as both cases and controls, while underpowered, identified a large number of nominally significant SNPs associated with genes that are significantly enriched in autism risk genes.

In a recent genome screen of multiplex sibships with prostate cancer, Suarez et al (2000) found nominally significant linkage at two distal markers approximately 20cM from the putative HPC1 region.

17 The metabolites with fold change ≥1.5 or ≤0.67 and p < 0.05 in t ‐test were considered nominally significant, and the metabolites with false discovery rate (FDR) < 0.05 were considered statistically significant.

The study identified 33 nominally significant loci, of which a subset of 9 loci were defined as being genome wide significant by permutation testing (1 locus in greyhounds, 6 loci in Rottweilers and 2 loci in Irish wolfhounds).

Three probes from the ESTHER/KORA study 12 and 1 from the twin study 11 were nominally significant in our study, using a fully adjusted model, in both the discovery and validation cohorts (Table S2 ), but they were no longer significant after FDR adjustment.

In the primary analysis, the hazard ratio for lung cancer was also nominally significant, and in the sensitivity analysis that censored patients at last contact, the hazard ratio for pancreatic cancer was nominally significant.

36 This variant was associated with a lower abundance of Parabacteroides, 36 a genus that is potentially linked to body weight and inflammation, 37 , 38 and with nominally significant altered abundance of certain carbohydrate-digesting genera, including higher abundance of Blautia, 39 a genus that might play a role in metabolic and inflammatory diseases. 40 As the studied European variant only results in a modest reduction in SI activity, the effect of the Arctic-specific complete LoF variant on microbiome composition could potentially be greater.

Although baseline patient demographic and disease characteristics were generally consistent between the geographic cohorts, several nominally significant differences were noted.

Although DQB1*05:02 ( P =6.3×10 −3 ) and DQB1*03:01 ( P =0.04) showed nominally significant associations with IHS-LST, there were no HLA-DQB1 alleles that reached the threshold after correction for multiple comparisons.

Motts Mill Virus and Craigies Hill Virus Affected the Expression of Genes Related to Development Of the 454 genes that displayed a logFC of more than 0.5 in response to Craigies Hill virus infection, only 4 were nominally significant (adjusted p -value threshold of 0.001; Figure 2 ).

However, this association was only nominally significant, prompting evaluation of additional patients as well as additional potential genetic loci.

The presented P -values are unadjusted and considered nominally significant as the cutoff for genome-wide significance is < 1 × 10 − 8 .

Multiple comparisons were addressed using the false discovery rate (FDR), with FDR < 0.05 considered statistically significant and FDR < 0.2 considered nominally significant. 10 Metabolite set enrichment analysis (MSEA) was used to evaluate associations between metabolite classes and hip fracture risk. 30 We calculated the normalised enrichment scores (NES), which typically range from −3 to +3, along with the FDR values in the MSEA analysis.

In ER-negative disease, CD20 + TIICs were associated with a better prognosis in partially adjusted models, but the effects were slightly attenuated in the fully adjusted models, with the association being nominally significant only for the stromal compartment.

The residuals were approximately normally distributed with a zero mean and constant variance. Individual Data Among three individual data predictor variables (age, biological sex, and prior psilocybin experience), only age showed correlation with DED, which was nominally significant.

Gene associations with p-values less than 0.05 were considered nominally significant.