“nominally significant”

There was a nominally significant association between CD28 expression on CD4+ T cells and response (CR or PR) at day 180 after CAR-T cell infusion (91.3% CD28+, range 56.9–99.9% for responders versus 79.4%, range 44.6–99.9% for non-responders, p=0.048, t-test), but no other statistically significant associations between clinical outcomes and the frequencies of immune cell subsets in PBMC samples or the infusion products.

3.5 Intersection and MR results Venn diagram displayed nominally significant genes obtained by the four analyses ( Supplementary Figure S3 ).

However, this result was only nominally significant due to Bonferroni correction for multiple testing.

All the nominally significant association peaks identified with the GLM remain in the CMLM, although most fall below the threshold for genome-wide significance.

We tested all nominally significant SNPs out of the discovery analysis in 2 replication samples, resulting in a total sample size of 894 patients.

The allelic effects of the 10 SNPs were consistent through the 3 independent RS cohorts and were nominally significant ( Table 2 ).

However, at 15 and 30 min postdose, the differences in MDS-UPDRS Part III scores were nominally significant and favored SC-APO, which may be expected based on the PK profile of SC-APO compared with SL-APO.

The association analysis revealed 29 nominally significant associations, of which nine survived the FDRbl correction for multiple testing.

P <0.05 was considered as nominally significant.

Furthermore, 11 DEPs from the above pathways showed nominally significant association with lung function recovery, with the associations consistent at two consecutive or all three follow-ups.

Although the replication sample was smaller than the UK Biobank sample and evidence for replication at APBA1 was only nominally significant, these effect sizes were remarkably similar to those observed in UK Biobank (3.05 kg m −2 and 2.08 kg m −2 for BSN and APBA1 , respectively).

It was found that some of the above ATC codes were nominally significant for increased cancer risk.

However, we do find a nominally significant association of higher brain stem volume and amygdala volume with age, which may reflect resilience for maintaining a normal level of cognitive functioning at higher age and potentially interacts with other neuronal factors of cognitive reserve (Stern, 2009 ; Steffener and Stern, 2012 ).

3.3 Pathway enrichment and single-cell analyses Based on PLACO, gene set enrichment analysis identified 800 nominally significant pathways associated with the MD-BASO trait pair, but none remained significant after Bonferroni correction.

Of these, 510 nominally significant genetic correlations were identified, spanning 401 distinct cortical MRI phenotypes (Fig. 1 , Supplementary Table 4 ).

We compared the distribution of the sample-specific edge-weights between the mild and severe groups and identified six edges which were nominally significant with a p -value less than 0.05: gPC1 with cPC2, gPC8 with cPC8 and cPC4, gPC3 with cPC10, gPC13 with cPC9, and gPC12 with cPC1 (Fig. 4B ).

However, it is also highly compatible with the presence of substantial publication bias and other selective reporting bias in this field resulting in exaggerated effects in mostly small studies (most of which coming from China) and in an implausibly high prevalence of nominally significant results.

We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: −0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it.

Female BMI was only nominally significant.

Markers associated with phenotype traits either at ‘close to genome-wide significant’ p-values or at ‘nominally significant’ p-values Results from tests of association pointed to only one risk variant (namely Chr15:40531386-rs12440118 from ZNF106 ) associated with HbA1c emerging at ‘close to genome-wide significant’ p-value of 3.41E-08 (with Benjamini–Hochberg FDR p-value of 0.0032) ( Table 2 ).

After Bonferroni correction for multiple testing, p-values less than 0.0125 were considered nominally significant.

We found nominally significant global genetic correlations among six trait pairs identified by both LDSC [ 13 ] and ρ-HESS [ 20 ] (FEV 1 and FVC with PUD, GORD, and IBS, Fig. 2 and Additional file 1: Table S2 ).

Raw p-values were adjusted for multiple comparisons using the Benjamini-Hochberg method separately for each matrix; we considered raw p-values <0.05 as nominally significant, and adjusted p-values (q) < 0.05 as statistically significant.

In an APOE-ε 4 conditional analysis, only rs283815 remains nominally significant (Table 1 ).

In that study, OCA2, KITLG, SLC24A4, and TPCN2, which are all associated with blond hair or blue eyes, did not show a nominally significant association with the risk of CM or BCC.