“nominally significant”

Analysis of individuals genotyped at MedD only for an effect on TNB A region (13.1) on SSC13 was identified as potentially harbouring a nominally significant putative lethal recessive haplotype (for more information see Additional file 4 ).

Generally, the same nominally significant anatomical trends were consistently observed in all species, although they more frequently survived correction for multiple testing in rats, likely because of their lower interindividual variability (fig.

The three-way interaction was nominally significant but did not remain significant after FDR correction.

Two adjacent CpGs show a nominally significant difference in methylation between the individuals prenatally exposed to famine and the time- and sibling controls ( Supplementary Table 2 , available as Supplementary data at IJE online).

This SNP was top-associated with L6-L15 ( P MinGWAS = 4.7e-10) and showed nominally significant association with L6-L15 in all cohorts, with similar effect sizes (except for TwinsUK due to QC failure).

23 , 35 Another problem may be the interference of sleep apnea with recognizing RLS, since there was a nominally significant association of the RLS questions with MEIS1 rs12469063 among those participants with lower AHI scores.

Although several mRNAs and miRNAs showed nominally significant correlations with age or AAK grade, only a limited number of these associations remained significant after correction for multiple testing.

In the Neapolis cohort, 18.9% of patients carried the rs41291957 A‐allele (AA+GA): this subgroup was associated with a significant reduction in the prevalence of CTO compared to patients homozygous for the G‐allele, despite the higher rate of concomitant diabetes (the correlation with diabetes, which was nominally significant, did not survive multiple‐testing correction).

A p -value of <0.05 was considered nominally significant.

We considered SNPs to be nominally significant if their P -value was below the classical Bonferroni threshold of 5 × 10 −8 (i.e., correcting for an estimated 1 million of independent SNPs).

For each study, if both tests being compared yielded two-sided p values <0.05 (nominally significant) or ≥0.05 (not nominally significant), the results were deemed concordant; otherwise, the results were classified as discordant.

Associations with a false discovery rate-adjusted q value < 0.1 were considered statistically significant, while p values ≤ 0.05 were considered nominally significant.

All nominally significant genes from this module were positively correlated with vaccine response.

Notably however, there was a nominally significant correlation of bipolar disorder with body mass index, and in pathway analyses, genes involved in insulin secretion were enriched ( 23 ).

We also compared our identified DMPs and DVPs with nominally significant DMPs reported by Bozack et al.

Nominally significant p -values (<0.05) of the initial analyses were Bonferroni-corrected as well, since each SNP was tested for multiple associations in the two sample populations, in which the nominal p -values were multiplied by the total number of tests performed.

In eQTL analyses using lung tissues Lung Microarray Study ( S3 Table ), rs56321285 is a nominally significant cis-eQTL for AOX2P (Laval and Groningen datasets) and CDK15 (Laval and UBC datasets).

indicated that CRY2 rs75065406 had a nominally significant association with MetS, but this association did not remain significant after correcting for multiple testing [ 8 ].

We selected the top 80 nominally significant SNP loci for replication testing or combined analysis (see methods ) in narcoleptics from two European cohorts typed on the Illumina ImmunoChip (1886 cases, 10,421 controls) and Affymetrix 6.0 arrays (807 cases, 1074 controls) [6] , [8] , ( Table S1 ).

We detected nominally significant/significant interactions between lipids (total cholesterol, HDL-cholesterol, LDL-cholesterol), the PPAR-γ2 Pro12Ala genotype and waist-to-hip ratio, fasting insulin, HOMA-IR and IR (9.30 × 10 −4 ≤ P interaction ≤ 0.04).

Nominally significant enriched terms were retained for results interpretation.

We identified 49 genes for which expression was significantly deregulated (FDR adjusted p-value 0.1) with CpG sites showing demethylation that is nominally significant (unadjusted p-value 0.05, Supplementary Table 14 ).

The original HPDI showed a weaker, nominally significant association with better cognitive function (0.12, −0.02 to 0.25, p for trend = 0.09).

The VICTOR trial was neutral for the primary endpoint, but its nominally significant mortality benefit made it consistent with the signal observed in the pooled analysis [ 6 ].

Gene-exercise interaction effects on cardio-cerebrovascular risk Formal interaction analyses revealed nominally significant SNP × exercise interactions for ischemic stroke at two loci.