“nominally significant”

Multiple exploratory correlation analyses were performed without formal correction for multiplicity; exact P values were reported, but nominally significant findings should not be considered confirmatory.

We also found nominally significant increases in brain MOBP levels (p Cer = 2.13×10 −2 –1.71×10 −7 ; p TCx = 1.55×10 −2 –1.57×10 −6 ) with rs1768208, which increases PSP risk [27] .

[ 30 ] that analyzed the outcome with metformin in patients with non-alcoholic fatty liver disease (NAFLD) or steato-hepatitis (NASH) with COVID-19 without diabetes, has also shown a reduced risk of hospital admission in metformin users (36/6700) (OR 0.42; 95% CI, 0.18–1.01; p = 0.05) compared to the non-users, although it was nominally significant.

The three EOFAD genes ( APP, PSEN1, and PSEN2 ) harbor several SNPs with nominally significant association with AD.

However, in the study of Renström and colleagues (3,885 non-diabetic adults mean aged 52.6 years), only a nominally significant interaction with sex was observed, with the P-value not being robust to multiple statistical comparisons [8] .

dataset yielded fewer putative direct targets and the corresponding comparisons were nominally significant but did not pass the multiple testing correction.

However, we identified nominally significant changes for several metabolites.

ETHOS used a Cox proportional hazard model adjusted for lung function and age, variables that were not used in the secondary Cox analysis in TORCH, which still showed a nominally significant difference, with a 19% reduction in risk ( 1 ).The ETHOS data suggest that a dose response of effectiveness may exist for mortality in a way not seen when exacerbations are the endpoint, with the number needed to treat for a mortality gain with 320 BFF being 80 patients per year.

The CTG-VL’s inclusion criteria require a nominally significant heritability derived from LD score regression 51 .

Within-Group Associations Between Auditory Psycholinguistic Abilities and Cognitive Outcomes Pearson analyses identified three nominally significant correlations and one additional near-threshold association.

When metabolites did not remain significant after FDR correction, they were interpreted cautiously as nominally significant exploratory findings.

We explored our significant and nominally significant SNP-volume associations in both our European-South Asian ancestry and full mixed-ancestry cohorts.

The nominally significant negative association of psychosis in HD with educational level ( table 4 ) also corroborates work showing that higher levels of education are associated with decreased schizophrenia risk. 43 We acknowledge several potential limitations of these data.

The P value <0.05 was used as threshold for nominally significant differential expression. gplot2 and pheatmap packages were used to draw the volcanic maps and heat maps, respectively. 2.3.

Third, our negative control outcome (varicose veins) yielded a nominally significant hazard ratio of 1.27, which did not survive Bonferroni correction and lacks any plausible biological relationship to CSU.

[29] In the present study, less obvious air pollution effect variation by genotype was suggested for GSTP1 rs596603 and the GSTT1 null variant, where air pollution exposure was associated with a higher and nominally significant risk of AMI in subjects with GT or TT genotype in GSTP1 rs596603 vs GG (OR 2.12, 95% CI 1.09–4.10 vs OR 1.40, 95% CIs 0.73–2.68), as well as for individuals carrying the non-null genotype of GSTT1 , i.e. the presence of a coding gene, compared to subjects with the null genotype (OR 2.02, 95% CI 1.13–3.60 vs OR 1.40, 95% CI 0.33–5.96).

nominally significant) and (ii) corresponding to a Rho values not significant in any of them (i.e. non-significant), and in each group we generated the distribution of TR:probe distances using bins of 1 kb.

Notably, mothers homozygous for the AGT haplotypes t-c-g and C-c-g had a RR of 4.6 (95% CI = 1.5-14.7, p = 0.01) and 3.0 (95% CI = 0.9-9.9, p = 0.07), respectively, with only the former being nominally significant.

Although the study did not meet its primary endpoint (least-squares [LS] mean change in PANSS total score at Week 6: −14.3 vs −12.2 for placebo; LS mean difference −2.0, 95 % CI –4.5 to 0.5; p = 0.11), post hoc subgroup analyses revealed a nominally significant benefit among patients receiving non-risperidone background therapy (n ̃ 130), with a mean PANSS reduction of −15.1 for COBENFY versus −11.7 for placebo (LS mean difference −3.4; 95 % CI –6.3 to −0.5; p ≈ 0.03) [ 106 ].

Expression Quantitative Trait Loci (eQTL) analysis We examined 127 TCN1 -related SNPs for associations with TCN1 expression and found that 6 were nominally significant at the 0.05 significance level.

In the mild AD APOE4/4 group, the effect on the Alzheimer’s Disease Assessment Scale—cognitive subscale (ADAS-cog) was 5.4 points, and effects on the functional outcomes of the Clinical Dementia Rating—Sum of Boxes (CDR-SB) and the Disability Assessment for Dementia (DAD) were also nominally significant.

The rs560887 ( G6PC2 ) was nominally significant in the combined sample and the rs533123 ( OPRD1 ), rs1049353 ( CNR1 , cannabinoid receptor 1) and rs10242595 ( IL6 , interleukin 6) showed associations in males (significant sex interaction identified for IL6 and nearly for CNR1 (P = 0.06)).

Analysis of MSigDB Hallmark gene sets further identified biologically pertinent, albeit nominally significant, coordinated changes: the epithelial–mesenchymal transition signature was positively enriched, whereas the DNA repair pathway was negatively enriched, suggesting a concomitant activation of tissue-remodeling programs and a potential decline in genomic maintenance ( Fig. 3 B).

These 23 kinases, which are important regulators of RhoGEFs, RhoGAPs, and actin binding proteins 18 , interact within a network that was itself enriched for the remaining 217 PSD proteins with nominally significant reductions in AD + P (Fig. 2 ).

We then measured detergent-soluble STMN2 protein in the frontal cortex by Western blot, which revealed a significant or nominally significant reduction of STMN2 protein in all FTLD-TDP cases compared to controls in unadjusted analysis and adjusted analysis when controlling for age and sex, respectively ( Figure 1A ; Supplementary Table S2 ).