“nominally significant”

Given the very high heterogeneity, this outcome was rated as very low certainty under GRADE ( Table 3 ) despite the nominally significant pooled estimate.

For the associations or correlations between metabolites and visual or cognitive impairment, a p value less than 0.05 was considered as nominally significant.

These associations were nominally significant (uncorrected).

These very low prior odds have a profound influence upon the odds that any nominally significant result identified in an association study is a true positive rather than false positive (the posterior odds).[ 91 ] From Figure 3 it is obvious why P -values in the range of 5% to 0.1% will nearly always be false positives, even in well-powered studies.

A p -value of <0.05 was considered nominally significant. 3.

Results: Of the 12 genes with definitive evidence for HCM (e.g., MYBPC3 , MYH7 , TNNT2 , ALPK3 ), 8 (67%) demonstrated nominally significant association with HCM on a population level, and 5 (42%) remained significant after Bonferroni correction, further supporting the validity of these genes in HCM panels.

In conditional analyses, the relationship between ΔBMI and MRS remained nominally significant after adjusting for each of the glycemic variables ( Fig 2A and S3 Table ), implying that the MRS is not solely a proxy for insulin sensitivity.

One of six tested SNPs in the TACR1 gene showed a nominally significant association with a decreased risk in symptomatic OA.

A summary of the output of these analyses are presented in Table 5 , and show that whilst there were some nominally significant observations with copy number haplotypes, only a total model of association with haemoglobin has a borderline significance with the global test, and therefore is the only one for which haplotype data should be subsequently examined.

Concerning CD86 MFI, nominally significant associations were observed for all B cell subsets in controls and for switched B cells in cases, but these trends did not survive correction for multiple testing ( Supplementary Figs 11 and 12 ).

Among others, we observed several statistically significant associations with educational attainment and cognitive performance, but also nominally significant associations with schizophrenia and major depressive disorder (Supplementary table S1.

26 We declared significant associations if (1) the ACAT-O p values passed the Bonferroni-corrected p value threshold at each tissue, (2) the Z scores produced were concordant among all PRS methods at each tissue, and (3) at least two PRS methods produced nominally significant results ( p -value tissue <0.05) at each tissue.

A p value < 0.05 was considered nominally significant.

In a third study, a nominally significant increase in singleton CNVs in BP cases compared with controls was found [Zhang et al., 2009 ].

[7] This pragmatic, randomized, double-blind, placebo-controlled, event-driven trial found that patients randomized to EQW had a numerically lower incidence of major adverse cardiovascular events, and a nominally significant reduction in all-cause mortality.

Any result exhibiting a nominally significant difference was considered to proceed to the second step.

If the reviewers decide not to combine the data quantitatively, a danger is that eventually they may end up using quasi-quantitative rules of poor validity (e.g., vote counting of how many studies have nominally significant results) for interpreting the evidence.

For FAR, the linear contrast was nominally significant (P for linear trend = 0.041); however, the EMMs were not monotonic across grades and no pairwise differences survived Bonferroni correction.

Salinity was only a nominally significant predictor of LVA while temperature was not significant.

However, only haplotype "C-A-T-C" showed a nominally significant association with PSC ARC risk.

This revealed a nominally significant enrichment of haplogroup T (HgT) in controls versus cases that could suggest a potentially protective effect of HgT against CFS.

As such, this post hoc analysis is exploratory, and all reported P values are nominal with values <0.05 considered nominally significant.

However, when applied to real datasets we find that the majority of genes are nominally significant.

We also performed a comparison of CI-DEGs identified at nominal significance ( p -value < 0.05) with each algorithm from bulk-DLPFC to nominally significant snDLPFC results (Fig. 4 b, Table S19 ).

Compared with the LR participants, the HR participants displayed a nominally significant elevation in regional-to-global metabolism in the left amygdala ( Table 4 ) during catecholamine depletion.