“nominally significant”

Although these interactions were nominally significant none of them remained significant after multiple-test correction.

There were no changes to gene expression that achieved genome-wide significance, although the analysis revealed two genes with nominally significant expression changes ( P ∼ 0.01 before correction for multiple hypothesis testing), including MUC4 and HRC that were induced 1.8-fold and 1.7-fold, respectively.

This study investigated the independent effects of these polymorphisms on human cognitive ageing, and the extent to which nominally significant associations with cognitive ageing were mediated by previously reported genetic associations with brain white matter tract integrity in this sample.

In case-only comparisons, only stressful life events had a nominally significant association with affective psychosis, which does not survive multiple testing correction (detailed results are provided in Table 2 ).

The nine nominally significant markers were very weakly to moderately correlated with each other, except FGF2 and GM-CSF (weighted Pearson correlation coefficient [rho] = 0.44) and FGF2 and IFN-γ (0.58).

This was a subquestion of death of a pet which was nominally significant in both analysis.

Two ADIPOQ SNPs, rs822354 and rs3774261, showed directionally consistent and nominally significant associations with serum HMW adiponectin in the replication sample ( Table 1 ), and the association of rs822354 reached genome-wide significance in meta-analysis of the two studies ( P = 3.67 × 10 −8 ).

Assessment of biological significance among Important CpGs Gene ontology (GO) analysis on the set of 3728 CpGs from models 1 and 2 revealed 403 nominally significant GO terms; among the 4150 important CpGs from Model 3, 382 nominally significant GO terms were identified.

Therefore, these nominally significant associations still need to be verified in other populations.

Second, the between-group differences in CAV1 and CAV2 were modest in magnitude and, although nominally significant, attenuated to a consistent trend after correction for multiple comparisons across the five candidate genes; the coordinated-repression interpretation consequently rests primarily on the CAV1-CAV2 co-expression relationship, which is robust to such correction.

In total, 64 genes were significantly positively associated with atherosclerosis, and 86 genes were significantly positively associated with myocardial infarction at a nominally significant level (FDR < 0.05).

For ELO, 5 of 11 genes have highly significant values of β 2 (Bonferroni-corrected p-value of less than 0.05), though all are nominally significant.

The locus showed nominally significant association in both the Italian and Spanish sub-analyses.

Individual domain scores of the AE‐QoL were improved for berotralstat‐treated patients but were not statistically different from placebo, with the exception of 1 domain (fears/shame), where patients in the 150 mg group experienced a nominally significant improvement (Figure 3 ).

Pathway analyses based on nominally significant genes revealed 27 enriched pathways shared by the Weeks 8 and 12 TPM groups.

Although the association of ABCA7 rs3764650 with AD has been confirmed in Caucasians (Harold et al., 2009 ; Lambert et al., 2010 ; Carrasquillo et al., 2011 ; Hollingworth et al., 2011 ; Omoumi et al., 2014 ; Cuyvers et al., 2015 ), GWAS studies in African Americans have found either none, or a nominally significant association (Logue et al., 2011 ; Reitz et al., 2013 ; N’songo et al., 2017 ).

22 ) used for GRS calculation reached nominally significant differences.

Those associations were identified as potentially causal association if: (1) IVW/contamination mixture test was FDR-significant, (2) confirmed by nominally significant weighted median results in the same direction of IVW and (3) nominally significant MR Egger analysis if there was any horizontal pleiotropy indicated by an Egger intercept significantly deviating from zero.

None of the tested candidate gene lists showed nominally significant enrichment for association signals in humans ( S6 Fig , S1 Table ), although the number of genes with significant association signals in the lists “increased systemic arterial blood pressure” and “decreased systemic arterial blood pressure” approached statistical significance.

The GWAS loci for four further traits showed at least a nominally significant overlap with putative selective sweep peaks (Fig. 5 , Supplementary Table 3 ), with balding measurements and leucocyte count nominally significant in both the XP-EHH and XP-CLR analyses.

Given the exploratory nature of our analyses, the results were not adjusted for multiple testing, and P values <0.05 were considered nominally significant.

While we observed some weak, nominally significant results, this study suggests that major alterations of immune cells in peripheral blood are not yet visible in healthy individuals at increased genetic risk and likely only occur later in the course of PD [ 35 ].

Nominally significant results for colon included age, height, and egg and fresh fruit consumption, while nominally significant findings for rectum included BMI, water piped into home, and foods cooked in oil.

Cipa + mig showed a nominally significant improvement in sitting %predicted forced vital capacity (%predicted FVC) compared with alg in the overall (combined naive and experienced) and ERT-experienced populations.

Differences between RCI and placebo were nominally significant at week 8 in the low-disease-activity subgroups (Figs. 1 A, B) and at weeks 8, 16, and 24 in BICLA responders (Fig. 1 C).