“nominally significant”

We also revealed nominally significant differentially expressed genes (DEGs) in our previous transcriptome data and identified 678 genes were downregulated, and 801 genes were upregulated in MEF2-VP16 overexpressed HeLa cells ( Figure 4B ).

By comparison, evidence from the MR analyses for N-acetyltryptophan and 3-aminoisobutyrate provided only weak and nominally significant evidence for these metabolites being causally associated with metabolic outcomes ( Table S2 ). 4.

A nominally significant mitochondrial genetic component ( p (h 2 mt = 0) ≤ 0.05) is detected for three traits: DESIRE, CIGPKYRS, and CRAVING but, after correction for multiple testing, only the CIGPKYRS and CRAVING remain significant ( p < 0.009; 78 pair-wise genetic correlations |mean ρ G | = 0.64).

Correlations with a p value < 0.05 were considered nominally significant and visualized in heatmaps.

One hundred fifty-three of 1027 metabolites assayed were significantly different based on disease status and 474 metabolites were nominally significant (Supplementary Table S1 ).

Without seed-matched comparisons and family-wise correction for the resulting multiplicity, a nominally significant cell can be weak evidence for general resilience.

In a human study, a homologous variant (c.753G>A; rs769896655) in CDH23 showed a nominally significant enrichment in individuals with schizophrenia.

As shown in Table 4 , a SNP located in the precursor 3′ stem of ssc-miR-30d showed a nominally significant association with arachidic acid (C20:0) content.

Coefficients with P ≤0.05 were considered to indicate a nominally significant association between the response and explanatory variables.

Robust candidates with nominally significant p -values were highlighted in the figures to facilitate interpretation.

In fact, genetic predisposition to MASLD tended to be associated with lower Lp(a) levels, and the association was nominally significant when considering the most complete PRS validated in the literature [ 33 ].

Of the 50 loci tested, 14 of the loci met our locus Bonferroni criteria and another 24 were nominally significant.

For the 750-mg dose, this change was nominally significant at day 13 (95% confidence interval − 3.23, − 0.018).

Results were considered nominally significant at a 5% level without controlling for multiplicity.

Results and discussion Association mapping of disease locus We found a nominally significant association between region 5 and RA.

Several of these differentially expressed genes in BipSeq-sACC also showed nominally significant DE in the same direction in at least one of the other three datasets (Fig. 2c ).

For metabolite association analyses, raw p-values < 0.05 were considered nominally significant, and false discovery rate (FDR)-adjusted p-values (q-values) < 0.05 were considered statistically significant after multiple testing correction.

Whether or not they are nominally significant, there is no way of experimentally testing whether syntenies supported by small numbers of genes are syntenic by descent or convergence.

MR estimates with p < 0.05 were considered nominally significant in this study.

For SNP rs5219 in KCNJ11 (HWE p = 0.004, WHO1999; HWE p = 0.01, WHO2013) and rs11605924 in CRY2 (HWE p = 0.007 WHO1999 and HWE p = 0.06, WHO2013), HWE values were nominally significant for the same criteria where an association was observed; these findings need to be replicated in independent cohorts.

tRNA tRNA-Leu-TAG-2-1 from the study-wide significant set also showed nominally significant hypermethylation with age (Fig. 5 a(xviii)).

Heterogeneity in effects for selected SNPs and regional visualization We evaluated the correlation between effect sizes and directions from the original GWAS analyses by computing the Pearson correlation coefficient for nominally significant SNPs within previously identified gene loci and generating beta-beta plots ( Supplementary Figure 1 ).

Results for the outcome of time to cardiovascular death or first HHF were not modified across key prespecified and post hoc subgroups, except for a nominally significant interaction for the SGLT-2i subgroup (Figure 3 ).

In addition, CNVs overlapping with GRM5 had a nominally significant association with BD.

If a protein presented nominally significant association but did not after correction, we considered it a suggestively significant result.