“nominally significant”

For example, nominally significant p -values in GWAS outputs can be reprioritized by leveraging their connectivity patterns in a tissue-specific network [ 163 ].

In children, nominally significant SNP × sex interactions were observed for the associations of rs2314339-T ( NR1D1 ) (β interaction = 4.9%, P interaction = 0.016), rs1801260-G (β interaction = −3.6%, P interaction = 0.031), and rs4864548-A ( CLOCK ) (β interaction = 3.2%, P interaction = 0.035) with percentage of energy from fat ( Supplemental Table S1 ).

In this subgroup, a nominally significant improvement in walking speed was observed within the per‐protocol population.

When considering the association analysis conducted in Japanese ethnicity by Ishida et al ( Ishida et al., 2020 ), there was a lack of replicated significant associations between studies, with only four out of 38 associations being nominally significant in our results ( Supplementary Table 4 ).

To take into account multiple testing for different regions, the associations with P -values below 1.84 × 10 −4 ( α = 0.05/272 outcomes) were regarded significant associations after Bonferroni correction and associations with P- values below 0.05 but above 1.84 × 10 −4 were deemed as nominally significant.

Initially, alcohol abuse was linked to Chromosome 4 in the area of LPHN3 utilizing two‐point linkage analysis in families with alcohol dependence to identify a nominally significant locus at D4S244 (Reich et al. 1998 ), which is just under 2.5‐Mb downstream of LPHN3 .

Although they did not reach the same level of significance, many of the formerly reported variants showed nominally significant p values in the same direction as those reported [26] .

After feeding fatty or non-fatty meals, levels of most of these indices were reasonably stable over 6 hours with only modest, but nominally significant, effects of time or feeding on levels of D-dimer, IL-6, IL-7, sCD14 and sCD163.

We prioritised the nominally significant SNPs by functional annotation and expression quantitative trait loci (eQTL) analysis in human brain, and we identified 33 SNPs tagging cis -eQTL in 32 different loci (referred to as eSNPs and eGenes, respectively).

Results with P < 0.05 but > 0.0167 are considered nominally significant and should be interpreted with caution.

Our finding of a nominally significant association between the Aβ42/40 ratio and WMH susceptibility, but not WMH volume, supports the notion that susceptibility measures may capture microstructural tissue alterations related to amyloid metabolism that precede volumetric changes.

( 28 ) Hence, we performed the GO analysis on nominally significant trans‐ eGenes to get more insight into potentially affected pathways rather than particular genes.

Thirteen nominally significant effect sizes were observed, while 16.73 significant effect sizes were expected ( p TES = 0.32), suggesting no evidence of excess significance.

Only rs1333042 ( P =0.029) was nominally significant (Figure 4 ).

[ 47 ] A P -value <.05 in the IVW analysis was considered to indicate a nominally significant correlation.

Tezepelumab Nominally significant improvements in prebronchodilator FEV1 versus placebo were observed in all tezepelumab groups from Week 4 through to the end of the study (120–150 mL at Week 52) [ 12 ].

However, a nominally significant difference was noted in the distribution of patients with a final diagnosis of sudden infant death syndrome. 3.3.

We observed a nominally significant trend toward enrichment of C19 microglia genes in multiple sclerosis and Alzheimer’s disease.

Significant GPR108 variants also exhibit suggestive (nominally significant) interaction effect with APOE for simple processing speed ( Table 2 ; Figure 3 B).

Fourth, the nominally significant association between premature cardiac complex and foveal thickness became insignificant after Bonferroni correction.

Nominally significant associations with patient outcome were reported for several variants, including rs727479.

Of these a total of 31 (39%) nominally significant SNPs passed multiple hypothesis testing correction (FDR < 0.05) with 23 being PCa disease-associated SNPs identified from GWAS.

Biological process GO analysis revealed no significant enrichment after correcting for multiple comparisons, though the GO term “Proteolysis” (GO:0006508) and multiple GO terms related to metabolism were nominally significant ( Figure S2 , Table S1 ).

A two-tailed P value < 0.05 was considered nominally significant.

Results from SMR suggest that was the case for all 24 genes, at least at nominally significant level, and for 5 genes at FDR q <0.05 ( Table 1 ; Supplementary Table 2 ).