“nominally significant”

The nominally significant P value for the largest study was extracted for each meta-analysis.

Given the 7 investigated SNPs, to reduce the risk of false positive findings with multiple testing, the limit of statistical significance was defined at 0.05/7 = 0.007, and a p between 0.05 and 0.007 was termed nominally significant.

In univariate MR analysis, significance was determined at P < 0.05/36, while P < 0.05 was considered nominally significant.

cg05575921 ( AHRR ) is a well-established CpG related to maternal sustained smoking; thus, we checked that this CpG was at least nominally significant in the cohort-specific results for maternal sustained smoking.

Of the ten biomarkers that were identified, nominally significant associations with T2D or glycaemic traits were reached for those genetic variants related to bilirubin, pro-B-type natriuretic peptide, delta-6 desaturase and dimethylglycine based on the summary data from DIAGRAMv3 or MAGIC.

Seven genes were validated in 41 TOF cases because of their nominally significant differences in methylation levels and their function in heart development.

If a protein showed a nominally significant association that lost significance after correction, it was classified as suggestively significant.

The association between screen time and depression varied significantly by sex ( P for interaction = .031), A nominally significant interaction was also observed for household income ( P for interaction = .015), whereas no significant effect modification was observed across the other subgroups, with all interaction P values exceeding .05 (Fig. 3 ). 3.6.

Conversely, we observed a nominally significant inverse association between normal-range FT4 levels and BD risk.

Statistical significance was set at p < 0.05; effects with q < 0.05 were considered statistically significant after FDR correction, whereas effects with p < 0.05 but q ≥ 0.05 were considered nominally significant.

The significance heatmap in Figure 2B showed that these pulmonary correlations were nominally significant based on unadjusted P -values.

32 Clinical Implications Our data indicate that measuring BDNF only marginally improves cardiovascular risk prediction. BDNF measurements did not improve the area under the receiver operating characteristic curve (for cardiovascular events); only IDI and NRI were nominally significant.

Relationships for which the p value was below 0.05 but above 0.0125 were considered nominally significant.

For outcomes that have nominally significant differences between FRDA and control groups at baseline, we will assess their relationship with the number of GAA repeats on both alleles, age of onset and disease duration using Pearson or Spearman’s rank correlation.

We identified 21 nominally significant genes associated with OS and 12 nominally significant genes associated with PFS ( Supplemental Tables 2.6 and 2.7 ).

Apart from LT-α, all results from the main analysis replicated (FDR < 0.05) in all settings where the analysis was feasible, with the one exception being the effect of IL-18R1 on hay fever, which was only nominally significant in one of the stricter settings ( Table 3 ).

We found 11 interactions that were nominally significant in our discovery cohort (the Marshfield PMRP biobank).

Results Single nucleotide polymorphisms (SNP) variants in the MEF2C gene showed nominally significant associations in all cognitive domains but for different SNPs across both the ethnic groups.

With regard to the observed nominally significant associations, the corresponding linkage block could be further investigated in order to uncover causal source for trait variations.

The p -values for the females-only sample for these SNPs were nominally significant but not significant when corrected for multiple testing (0.047 and 0.038, respectively).

However, it was also highly compatible with the presence of substantial publication bias and other selective reporting bias in this field, which results in exaggerated effects in most small studies and in a high prevalence of nominally significant results.

Table 3 shows that there were 19 nominally significant IGene-pw and 9 significant BDNF-pw that were associated with mood disorders.

In particular, nominally significant associations observed in subgroup analyses may represent chance findings and should be validated in future studies.

From this study, we included those genes that showed significant association with SC in all the three samples (eight genes) or in two samples with at least two nominally significant SNPs in each sample (55 genes).

Nominally significant improvements in change from baseline were observed beginning at 3 months through to 24 months in SOFAS and CGI-S for both year 1 and year 2 completers (Table 3 ).