“nominally significant”

The results that were nominally significant and consistent with the expected phenotype correlations can be interpreted as supportive evidence of genetic overlaps .

3 SNPs were nominally significant with the most statistically significant difference observed for rs514659 in the ABO gene determining the ABO blood group (frequency of the minor allele C in STEMI patients 48.06% and in NSTEMI patients 43.26%; X 2 P = 0.0066), originally reported to be specifically associated with MI in presence of CAD [ 20 ].

These data are presented in Tables S1 and S2.Of these tests, the majority showed no association with either fluid or crystallized intelligence, but one test, total CNV counts for deletions in the range 200–500 kb, showed a nominally significant p-value of 0.039 with g f , although this is not robust to multiple testing correction.

Results with P < 0.001 were considered statistically significant after correction, whereas those with values between 0.001 and 0.05 were considered nominally significant.

The difference in frequency for each nucleotide and amino acid between samples from ticks and humans was determined and a Fisher’s exact test was performed, with a value considered nominally significant if the two-tailed p -value was less than 0.05.

Of the individual SNP analyses, only rs6548238 near TMEM18 , rs10838738 in MTCH2 , and rs7498665 near SH2B1 showed nominally significant interactions with physical activity level on BMI or obesity risk ( Tables S3 and S4 ), but none survived adjustment for multiple comparisons.

Over-Representation Analysis (ORA) maps interesting genes within the transcriptome profiles to curated pathways or functional categories (Reactome and Gene Ontology were used) and assesses the statistical significance of the overlap; transcripts undergoing nominally significant changes were used.

The results of the gene-based analysis are shown in Table S11 , where eight genes were nominally significant in CAGES and nine in the Brisbane Adolescent Twin Study (BATS).

In the small sample of 12 patients with eGFR values of 15–29 mL/min/1.73 m 2 , the high event rate (66%) produced an adjusted HR of 2.50, with a nominally significant p -value (0.019).

Analysis of the transcriptomic datasets Pre-normalized public circadian transcriptomic microarray (GEO accession: GSE54650 7 ) and aging transcriptomic data sets (GEO accession: GSE57809 26 and GSE6591 27 for the liver and lung, respectively) were used for detection of circadian (see “Detection and analysis of circadian epigenetic oscillations”) and nominally significant aging mRNAs (see “Aging analysis for the mouse tissue DNA samples”).

If the reviewers decide not to combine the data quantitatively, a danger is that eventually they may end up using quasi-quantitative rules of poor validity (such as vote counting of how many studies have nominally significant results) for interpreting the evidence.

In addition to immunotherapy, the association between thymectomy and reduced generalization risk in antibody-positive patients was nominally significant but did not satisfy the proportional hazards assumption, indicating an unstable effect.

Although several nominally significant associations were observed between modules and various histopathological features (Fig. 2b ), only positive correlations between M4/ulceration and M6/lymphoid aggregates remained significant after adjusting for multiple testing ( P adjusted < 0.05; Fig. 2b ).

However, if taking into account multiple comparison of 10 different parameters, this nominally significant result would not be statistically significant.

Furthermore, none of our lead 814 SNPs were nominally significant in the Neale Lab total energy intake GWAS ( P > 0.05/814).

Credibility and quality of the evidence assessment The credibility of the evidence of each association will be assessed on the basis of the following criteria: (1) associations with the number of participants of more than 1000, the P value of < 1 × 10 − 6 , the 95% PIs excluding the null, the largest study indicating a nominally significant effect size, the I 2 statistic of < 50%, no evidence of small-study effects and excess significance biases will be classified as convincing evidence (class I); (2) associations with the number of participants of more than 1000, the P value of < 1 × 10 − 6 , and the I 2 statistic of < 50% will be cl

In particular, the gene-set FMRP targets were not even nominally significant despite strong evidence for association in that study ( 2 ).

For example, of 22 tuberculosis-associated genes, none were significantly associated in a GWAS of 11,425 Africans, nor were these genes overrepresented among nominally significant results 76 , 77 , 78 .

Although the current nominally significant findings should be interpreted with caution and need replication in independent cohorts, this study supports the strategy to combine genetic approaches to determine the molecular mechanisms underlying bipolar disorder. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2013 Jul 29; Accepted 2014 Jul 11; Collection date 2014.

To control type 1 error, a significant taxon ( P < 0.05) that could be replicated in the independent GUGC cohort was defined as “replicated”; other significant MR results ( P < 0.05) were defined as nominally significant.

Large-scale GWASs for regional cortical surface area and thickness have identified 369 genome-wide nominally significant loci related to cortical structures [ 18 ]. 26% of the variation in average cortical thickness and 34% of the variation in total surface area can be explained by common single-nucleotide polymorphisms (SNPs) [ 18 ].

Bivariate analyses were subsequently performed only for trait pairs with nominally significant univariate results.

Interaction P values ≤0.05 were considered to be nominally significant.

However, a prespecified subgroup analysis of patients with high bronchodilator reversibility (post-bronchodilator FEV1 improvement ≥20%) demonstrated a nominally significant improvement in ACQ score.

We thus identified nominally significant loci in Treg cells and then used LCLs as a confirmation dataset.