“nominally significant”

We introduce NetWAS, which combines genes with nominally significant GWAS p-values and tissue-specific networks to identify disease-gene associations more accurately than GWAS alone.

The number of nominally significant associations across all susceptibility regions ranged from only 1 in Japanese to 11 in African Americans with the most statistically significant association observed through locus fine-mapping noted for rs3832016 (OR = 1.16, p = 2.5×10 −5 ) in the SORT1 region on chromosome 1p13 .

P values <0.05 were considered nominally significant. 2.

Despite only one nominally significant SNP, ADH5 contained two other SNPs with borderline significance including one SNP (rs1154415) with a significant odds ratio (OR = 1.54, 95% CI: 1.06, 2.24) comparing the homozygous GG genotype to the homozygous AA (Figs. 3 and 4 ).

Among 543 proximal genes with eQTL scores, 54 showed nominally significant correlations between their eQTL scores and SA; 4/54 genes ( HADHB , PRRT2 , TMEM44 , CORO1A ) survived FDR correction (Fig. 2E and Supplementary Data 9 ).

Several of the variant sets significant in our primary analysis were nominally significant in the other populations.

We used raw value of p < 0.05 as threshold for nominally significant differential expression.

The 18% nominally significant risk reduction of the primary outcome in the Americas has encouraged societies in the US to believe that, if properly implemented, spironolactone may improve outcomes in patients with HFpEF. 9 In HFpEF patients with resistant hypertension from the Americas enrolled in TOPCAT, a post hoc analysi

We performed Fisher’s exact test for overrepresentation of smoking-related CpGs among nominally significant PM-related CpGs.

We observed nominally significant SNP x smoking interactions for PTBP2 rs11165643 ( P interaction = 0.045), HIP1 rs1167827 ( P interaction = 0.015), C6orf106 rs205262 ( P interaction = 0.032) and GRID1 rs7899106 ( P interaction = 0.043) (Fig. 4 ).

Daytime dozing showed a nominally significant negative genetic correlation with PD ( \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} ${r}_G=-0.1$\end{document} , p -value = .0485).

Results: The analyses showed nominally significant associations between the FLT1 variants rs7993418 and rs9582036 and survival.

Additionally, nominally significant improvements were reached in the largest pre-specified population (the ERT-experienced group) for both 6MWD and FVC.

However, highly significant numbers of the nominally significant genes from the earlier cohort overlapped with the significant genes from the additional cohort benefitting from increased tumor numbers and power (Supplementary Fig. 5b and Supplementary Data 8 ), a further indication of these expression differences being reproducible and robust.

The method of Storey and Tibshirani ( 96 ) was used to estimate false discovery rates (FDRs) for nominally significant genes.

A recent study has reported nominally significant association for SNPs in ARNT2 and SIM1 with autistic traits in a general population sample [ 28 ].

CD4 T cell-specific peaks were nominally significant at a p -value of 0.013 but did not survive correction for multiple hypothesis testing (Bonferroni-corrected p -value threshold of 5.6×10 −3 ).

Finally, while age of the study partner did not relate to study partner reported CFI score, there was a nominally significant modifying effect of study partner age on the relationship between Aβ status and CFI score.

A P value of < 0.05 was considered nominally significant.

For instance, differential DNA methylation patterns between OCD patients and healthy control probands have been described for the oxytocin receptor ( OXTR ) gene [ 4 – 7 ], the serotonin transporter ( SLC6A4 ) gene [ 8 ], the monoamine oxidase A ( MAOA ) gene [ 9 ], the brain-derived neurotrophic factor ( BDNF ) gene [ 10 ], and, on a nominally significant level, the gamma-aminobutyric acid B receptor 1 ( GABBR1 ), estrogen receptor 1 ( ESR1 ), myelin oligodendrocyte glycoprotein ( MOG ) genes and again the brain-derived neurotrophic factor ( BDNF ) gene [ 11 ].

We presented nominally significant results to provide a clue to understand relationships between methylation in blood and gene expression in lung tissue.

Such analyses in ACCORD ( 4 ) demonstrated nominally significant heterogeneity for 3 of the 38 factors examined.

There was no association between relative TL and the development of MDD and there was a nominally significant association between TL and PTSD.

The results were similar in men and women except for a significant interaction ( p =0.003) for soft drinks; the trend was in the same direction, but stronger in women ( Supplementary Table 2 ). Food preferences across the FTO genotypes in strata of BMI When we stratified for BMI, the trends across the FTO genotypes were similar except for the consumption of juice ( p -interaction=0.04), which indicated a nominally significant increased intake for the A-allele carriers among overweight individuals but not among the normal weight individuals ( Table 3 ).

The full list of the nominally significant miRNAs in the differential expression analysis results is provided in Supplementary Table S1 .