“nominally significant”

Ingenuity Pathway Analysis (IPA) was employed twice: (i) before the ALIGATOR statistics, to characterize the composition of our interactomes ( Table S2 ), and (ii) on the genes with nominally significant evidence of association [1] that ALIGATOR took as representative of each interactome-SNP relation ( Table S3 ).

Although there was a nominally significant interaction between NYHA class and the effect of dapagliflozin, NYHA class and KCCQ-TSS score were dissociated across the spectrum of LVEF at baseline and the effect of dapagliflozin was consistent across the range of KCCQ-TSS scores included.

The three genome-wide significant results were then investigated further by examining their association with coronary artery disease (CAD) using a large sample (n = 5,765 CAD; n = 7,624 controls) with two linked SNPs, located in the ELF5 gene region, nominally significant.

We also examined interactions between genetic factors (the PRS and top variants) and the taxa associated with asthma; none were significant after adjusting for multiple comparisons ( q ≥ 0.90), though many were nominally significant (Supplementary Data 12 ).

Therefore, we also applied a more lenient threshold of p < 0.01 for correcting multiple testing results as nominally significant ( Zhu et al., 2024 ).

Extracting data from several samples with BPD ( n = 1461) and SUD ( n = 400), these authors identified nominally significant SNPs in 69 high-risk genes that were common between the BPD samples and 23 of them were also associated with higher risk of SUD.

Functional enrichment analysis was performed on all nominally significant metabolites list from the univariate analysis using Fisher’s exact test and was followed by the FDR multiple testing correction method.

To estimate effect modification by sex or pubertal status, interaction terms of the respective SDQ (sub‐)scale separately with sex or puberty onset were included in the adjusted models and followed by stratified analyses for these two factors if the interaction term was nominally significant.

In the present study, many of our differences were only nominally significant and did not pass multiple testing corrections, and hence should be interpreted with caution.

However, through MR analysis, we observed a nominally significant association of genetically predicted copper levels with reduced eGFR and rapid kidney function decline, but no association was observed with albuminuria.

To assess the sensitivity of pain DMRs to methylation quantification of MeDIP-seq data, we also performed analyses controlling for CpG density 29 and MeDIP-seq fragment size in the discovery sample ( Supplementary Figs S7 and S8 ), and found that the majority of top-ranked pain DMRs remained nominally significant, although their relative rank could change.

We regarded a two-tailed p<0·05 as nominally significant.

All GWS SNPs in this region yielded nominally significant opposite effect for the coded allele in TBLH-BMD as compared to TB-LM, despite the positive correlation between these traits.

Of these 43 signals, 4 signals were independently identified in both EAS-ancestry and EUR-ancestry cohorts; 27 were only identified in EAS-ancestry cohorts, 9 of which were also nominally significant in EUR-ancestry cohorts; 2 were only identified in EUR-ancestry cohorts, both of which were also nominally significant in EAS-ancestry cohorts; 10 were identified only after trans-ethnic meta-analysis ( Figure 4 B; Table S5 ).

These nominally significant interactions indicate that the risk increase by 9p21 genetic variation may at least partially be mediated through deleterious effects on glucose and lipid metabolism, dependent on environmental risk factors of CVD.

Of 447 total Operational Taxonomic Units (OTUs), a differential abundance of 16 nominally significant OTUs between the groups was observed.

We caution that these findings, while nominally significant, neglect plausible ancestry-differential COVID-19 infection incidence and/or ascertainment in our NYC cohort (which may strongly confound HLA frequency comparison), as well as intrinsic imprecision of diplotype inference from RNA data, linkage among class I HLA genes (and other major histocompatibility complex loci), and/or other sequence variation distinctive to specific subtypes of surveyed haplogroups.

Mendelian randomization analysis Testing the hypothesis that major depression results in changes of circulating metabolites in the Mendelian randomization analysis (MR), nominally significant results were obtained for 2-aminooctanoate and 10-undecenoate (11:1n1), under the MR-Egger method and weighted median method, respectively.

We found nominally significant differences in two variables: During pregnancy, the feasibility study mothers had lived in more overcrowded conditions (mean crowding index, 1.75; 95% CI, 1.58–1.92) compared to the larger SPS cohort [(mean crowding index, 1.57; 95% CI, 1.55–1.59) (effect size, 0.20)] and had scored higher on the Edinburgh Depression Scale [(mean, 14.10; CI, 13.00–15.21) versus (mean, 12.88; CI, 12.74–13.03) effect size 0.21] (NB: a score of 13 or above indicates a high likelihood of depression).

An interaction for DISYPS Self at the 3 mg/L threshold was nominally significant but did not remain after FDR correction.

FTO SNPs become only nominally significant for both alcohol-related traits: the p value for the lead SNP for AUDIT-C, rs9937709, decreases in significance from 5.53 × 10 −14 to 1.42 × 10 −5 and for the lead SNP for AUD, rs11075992, it decreases in significance from 3.22 × 10 −10 to 3.02 × 10 −5 .

Meanwhile, the same combination cannot be considered a minimal set in the entire group, though it is nominally significant and withstands the Bonferroni correction, since the significance level of association of MIR223 *T by itself ( p corr = 0.0068) is lower than that of the combination ( p corr = 0.041).

In this study, we focused on miR‐499‐5p, a miRNA which after correction for multiple testing showed a nominally significant association with BD in a recent GWAS (Forstner et al , 2015 ).

Although there was an attenuated, nominally significant PLR association for all gliomas combined, MR estimates for IDH wt became reversed in sensitivity analyses, suggesting that the impact of PLR on disease susceptibility is likely restricted to the IDH mut subtype.

We adjusted for a variety of risk factors, and the positive association of sCD163 SNPs with CHF would argue against residual confounding for this outcome, although this association was only nominally significant.