“nominally significant”

In the same vein, we counted all observed nominally significant associations and determined the corresponding p -value as the proportion of sets of expected results showing the same or a larger number of nominally significant associations.

p -Values above the significance threshold but less than 0.05 were considered nominally significant.

However, in the Cape Verde sample all of the markers remain nominally significant after conditioning, except for rs1448484 after conditioning for rs2636060.

List of all nominally significant associations with hepatic fat in PMBB for single variants that have been previously associated with hepatic fat or NAFLD.

In a discovery association analysis, this CNV was noted to have a protective effect for schizophrenia but was only nominally significant [ 50 ].

A two-tailed p -value < 0.05 was considered nominally significant, acknowledging that correction for multiple testing has not been performed.

For WHRadjBMI, only 1 SNP from Approach 4 was not significant following meta-analysis with our results: rs12608504 near JUND remained GWS for SNPadjSMK, but was only nominally significant for interaction ( P SNPint =0.013).

The EuroSCORE was log transformed (log EuroSCORE) as this achieved a substantial (nominally significant) improvement in model fit, as judged by the Aikaike’s information criterion.

Nominally significant associations were observed for several other metabolites; lower ratios of 3-hydroxybutyrate and saturated fatty acids to total fatty acids and of total cholesterol to total lipids in very low-density lipoproteins were associated with a higher EM risk (OR, 0.863; P =0.015; OR, 0.865; P =0.030; OR, 0.855; P =1.51×10 −4 ).

Nominally significant differences in bacterial composition abundance were observed at both phylum and genus levels: Staphylococcus , Cutibacterium , and Rhodocytophaga were enriched in the D0 group, while Streptococcus (genus) and Lactobacillales (order) showed significantly higher relative abundance in the D60 group (nominal P < 0.05).

In line with this finding, analyzing the correlation between LFC values of nominally significant genes across neuronal cell populations revealed a stronger correlation in transcriptomic changes between neuronal cells within the same brain region, as compared to neurons from distinct brain regions ( Figure S7 ).

FDR-adjusted p values <0.05 were regarded as significant, unless explicitly stated as nominally significant p values.

However, MR with rs8106657 alone did not produce any statistically significant findings, except for a nominally significant result for the Gene ATLAS dataset ( P MR = 0.02), and β MR values were generally less than those obtained in MR with rs505922 alone.

Especially, the expressions of WWP2 , EIF3H , and SNX17 showed nominally significant differences (see ‘Materials and methods’ and Figure 1—figure supplement 10 ).

For that, publicly available summary statistics of nominally significant variants with ADA immunogenicity in 96 Spanish Caucasian European CD patients were used [ 75 ].

We therefore followed up a large number of nominally significant obesity-associated SNPs in a step-wise manner by genotyping additional cohorts, starting with cohort Swedish 2.

Fisher z sensitivity analyses indicated that 7 of the 12 originally significant EEG–EMG associations remained nominally significant ( Supplementary Table S5 ), and supplementary PLI/iCoh analyses identified significant associations involving three of the five principal electrode pairs (T7–T8, FC5–F3, and FC6–F4; Supplementary Table S4 ).

False discovery rate was limited to 10% given our sample size and the number of nominally significant interactions with race.

CASP1 and IFI27 were nominally significant and considered exploratory.

Nominally significant regional case–control associations (i.e., which did not survive multiple testing correction) were found for the AIs of inferior parietal cortex thickness, cuneus surface area, parahippocampal gyrus surface area, and nucleus accumbens volume ( Fig. 2 and SI Appendix , Table S5 ).

We also showed that cis-risk for schizophrenia and depression was significantly enriched after controlling for multiple comparisons ( P Bonf < 0.05) in lymphoid but not myeloid cells (confirming in this dataset the convergent, nominally significant results for these disorders in the Roadmap dataset).

In addition, a nominally significant association of this SNP with FTND was found.

Results with corresponding p -values > 0.017 but ≤0.05 are referred to as ‘nominally significant.’ Visual inspection of quantile-quantile plots was used to determine the normality of model residuals.

In this work, we address this challenge by using mouse baseline AHR association measures and searching among previously published nominally significant EVE Consortium GWAS meta-analysis results [26] to identify genes that may be associated with asthma.

Although nine of the 74 models were nominally significant at α = 0.05, this was not much higher than might be expected by chance, and the directions of the associations were inconsistent and contradictory.