“nominally significant”

The significance threshold was set to 0.0025 and p -values below 0.0025 were considered statistically significant, while p-values between 0.0025 and 0.050 were considered nominally significant.

63 A similar approach on 148,508 individuals, of whom 22,080 had at least one parent with AD/dementia or AD diagnosis themselves, found a nominally significant enrichment of rare ABCA7 variants in disease, although an OR was not reported. 64 Power in this cohort to find significance may have been decreased by the proxy approach in which not all 22,080 AD‐classified individuals actually developed AD, carried risk variants or may have had parents with other types of dementia.

Premutation expansions in ATXN1 showed a nominally significant association with ALS susceptibility, while pathogenic expansions in NIPA1 displayed a nominally significant association with ALS survival.

A P-value of less than 0.05 was considered nominally significant.

APOB, APOC3 and its subfractions (heparin precipitate, heparin-soluble [HS]) and apolipoprotein-defined lipoprotein subclasses–classified Lp-B were associated with any-CVD in unadjusted analyses, and association of APOC3-HS remained nominally significant in adjusted analyses.

Results Eighteen immune cell signatures were found to have nominally significant associations with VTE according to the IVW method.

For both conditions, merely 2 out of 48 specifications yielded nominally significant outcomes, which means that evidence for any beneficial effects of KV448 or other music on epilepsy seems doubtful.

Gene-disease pairs nominally significant (P IVW < 0.05) in Mendelian randomization were considered as potential causal candidates.

Assuming that many of these nominally significant results likely represent false positives, we focus on the eight correlations that emerged in at least 5% of the simulations.

Results were reported as beta (β) values with standard errors for continuous outcomes, and odds ratios (ORs) with 95% confidence intervals (CIs) for binary outcomes; p-values below 0.05 were considered nominally significant.

Following Bonferroni correction, P < 0.0038 was considered to indicate statistical significance, and P values ranging from 0.0038 to 0.05 were considered to indicate a nominally significant association.

Although none of the SNPs in the discovery cohort achieved genome-wide significance, 10 of the 50 SNPs carried forward for replication approached genome-wide significance and were also at least nominally significant in the replication cohort; the replicated SNPs are shown in Table 2 .

At week 52 of the TULIP-1/TULIP-2 treatment period, a higher proportion of patients attained DORIS remission with anifrolumab versus placebo regardless of IS history; the improved rates of DORIS remission with anifrolumab were nominally significant in both IS-inexperienced and IS-experienced patients.

Species that were FDR-significant in all 4 models in the discovery sample and were at least nominally significant for localized disease experience in MTG data were termed “significant species”.

Higher baseline GFAP was associated with faster longitudinal increases in ventricular volume ( P < 0.0001), and a nominally significant association with steeper declines in amygdala volume which did not survive FDR correction for multiple comparisons.

While both the sQTL and hQTL are nominally significant for an eQTL association, colocalization analysis reveals that only the hQTL and eQTL are probably caused by the same genetic variant (posterior probability of full colocalization, PPFC >0.5).

rs705702 was not associated with PCOS in the current study and was only nominally significant in previous European studies ( 13 ).

For microvascular complications, we did observe a nominally significant association for the PGS of age-related macular degeneration (HR = 1.03 (1.01–1.06)), but not chronic kidney disease (HR = 1.00 (0.98–1.03); Supplementary Fig. 19 and Supplementary Table 6 ).

In the International Glaucoma Genetics Consortium dataset for CCT [ 22 ], there were a number of nominally significant associations; however, none of the markers remained significant after corrections for multiple testing.

Most ether lipids measured display mean levels that increase with phenformin treatment, though these changes are either nominally significant or exhibit a nonsignificant trend because of the strict threshold required to reach significance when correcting for multiple hypotheses.

Three had nominally significant P-values (i.e. <0.05), and two of these associations supported the top 5 primary GWAS associations ( Table 3 ).

Only a nominally significant association (p-val < 0.05) was found among white individuals who were vitamin D sufficient compared to vitamin D deficient (OR = 0.82, 95% CI 0.68–0.99, p-val = 0.036) (Table S1 ), however, it was not statistically significant after Bonferroni correction (p-val > 0.003).

In both the Autism Spectrum Disorder and the Oppositional Defiant Disorder/Conduct Disorder group, increased time to first fixation on the eyes of fearful faces only was nominally significant.

Similarly to Aung et al, 16 who reported a nominally significant effect between LTL and LV stroke volume, there were also significant associations between LTL and LV end‐diastolic and end‐systolic volume, but these did not survive multiple testing correction.

In contrast, AGT rs5051, ATG rs699, and AGT rs4762 demonstrated no statistically significant associations with SBP or DBP changes after multivariate adjustment, despite some nominally significant findings observed in unadjusted (crude) analyses.